Search Results - "Wright, Stephen H."

Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates by Sandoval, Philip J, Zorn, Kimberley M, Clark, Alex M, Ekins, Sean, Wright, Stephen H

“…Organic cation transporter (OCT) 2 mediates the entry step for organic cation secretion by renal proximal tubule cells and is a site of unwanted drug-drug…”
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Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells by Zhang, Xiaohong, Wright, Stephen H

“…MATE1 (multidrug and toxin extruder 1) and OCT2 (organic cation transporter 2) play critical roles in organic cation excretion by the human kidney. The…”
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Addressing the Clinical Importance of Equilibrative Nucleoside Transporters in Drug Discovery and Development by Hau, Raymond K., Wright, Stephen H., Cherrington, Nathan J.

“…The US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Pharmaceuticals and Medical Devices Agency (PMDA) guidances on small‐molecule…”
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Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters by D'Souza, Lucas J, Wright, Stephen H, Bhattacharya, Deepta

“…The fluorescent derivative of glucose, 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)-amino]-D-glucose (2NBDG), is a widely used surrogate reagent to visualize…”
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Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K by Astorga, Bethzaida, Ekins, Sean, Morales, Mark, Wright, Stephen H

“…The present study compared the selectivity of two homologous transport proteins, multidrug and toxin extruders 1 and 2-K (MATE1 and MATE2-K), and developed…”
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Molecular and Cellular Physiology of Renal Organic Cation and Anion Transport by Wright, Stephen H, Dantzler, William H

“…Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona Organic cations and anions (OCs and OAs, respectively) constitute an…”
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PF‐07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID‐19 patients by Hau, Raymond K., Wright, Stephen H., Cherrington, Nathan J.

“…The ongoing pandemic of severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) and subsequently, coronavirus disease 2019 (COVID‐19), has led to the…”
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Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics by Wright, Stephen H.

“…Organic cations (OCs) constitute a diverse array of compounds of physiological, pharmacological, and toxicological importance. Renal secretion of these…”
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Twelve Transmembrane Helices Form the Functional Core of Mammalian MATE1 (Multidrug and Toxin Extruder 1) Protein by Zhang, Xiaohong, He, Xiao, Baker, Joseph, Tama, Florence, Chang, Geoffrey, Wright, Stephen H.

“…The x-ray structure of the prototypic MATE family member, NorM from Vibrio cholerae, reveals a protein fold composed of 12 transmembrane helices (TMHs),…”
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Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier by Hau, Raymond K, Miller, Siennah R, Wright, Stephen H, Cherrington, Nathan J

“…The blood-testis barrier (BTB) formed by adjacent Sertoli cells (SCs) limits the entry of many chemicals into seminiferous tubules. Differences in rodent and…”
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Simulations of substrate transport in the multidrug transporter EmrD by Baker, Joseph, Wright, Stephen H., Tama, Florence

“…EmrD is a multidrug resistance (MDR) transporter from Escherichia coli, which is involved in the efflux of amphipathic compounds from the cytoplasm, and the…”
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Molecular and cellular physiology of organic cation transporter 2 by Wright, Stephen H

“…Organic cation transporters play a critical role in mediating the distribution of cationic pharmaceuticals. Indeed, organic cation transporter (OCT)2 is the…”
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Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients by Marie, Solène, Frost, Kayla L., Hau, Raymond K., Martinez-Guerrero, Lucy, Izu, Jailyn M., Myers, Cassandra M., Wright, Stephen H., Cherrington, Nathan J.

“…The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes…”
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Pentavalent Arsenic Can Bind to Biomolecules by Raab, Andrea, Wright, Stephen H., Jaspars, Marcel, Meharg, Andrew A., Feldmann, Jörg

“…As biomolecules go: By identifying the dimethylarsinothioyl glutathione complex in arsenic‐exposed cabbage, it was shown that pentavalent arsenic can bind to…”
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Generation of resting membrane potential by Wright, Stephen H

“…Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona 85724 Address for reprint requests and other correspondence: S. H…”
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Molecular identification and functional characterization of rabbit MATE1 and MATE2-K by Zhang, Xiaohong, Cherrington, Nathan J, Wright, Stephen H

“…An electroneutral organic cation (OC)/proton exchanger in the apical membrane of proximal tubules mediates the final step of renal OC excretion. Two members of…”
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Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters by Miller, Siennah R., Jilek, Joseph L., McGrath, Meghan E., Hau, Raymond K., Jennings, Erin Q., Galligan, James J., Wright, Stephen H., Cherrington, Nathan J.

“…Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Although the 5‐year survival rate is high, some patients respond…”
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Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3) by Astorga, Bethzaida, Wunz, Theresa M, Morales, Mark, Wright, Stephen H, Pelis, Ryan M

“…This study examined the selectivity of organic anion transporters OAT1 and OAT3 for structural congeners of the heavy metal chelator…”
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Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye by Pelis, Ryan M, Shahidullah, Mohammad, Ghosh, Sikha, Coca-Prados, Miguel, Wright, Stephen H, Delamere, Nicholas A

“…The nonpigmented epithelium (NPE) of the ciliary body represents an important component of the blood-aqueous barrier of the eye. Many therapeutic drugs…”
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Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2 by Suhre, Wendy M, Ekins, Sean, Chang, Cheng, Swaan, Peter W, Wright, Stephen H

“…Organic cation transporters are important for the elimination of many drugs and toxins from the body. In the present study, substrate-transporter interactions…”
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