Search Results - "Wright, Paul W."
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Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination
Published in Cell reports (Cambridge) (28-11-2023)“…Previous studies of the murine Ly49 and human KIR gene clusters implicated competing sense and antisense promoters in the control of variegated gene…”
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Identification of trophoblast‐specific elements in the HLA‐C core promoter
Published in HLA (01-11-2018)“…There are several aspects of HLA‐C gene expression that distinguish it from the HLA‐A and HLA‐B genes. First, HLA‐C is expressed by extravillous trophoblasts,…”
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Identification of an elaborate NK-specific system regulating HLA-C expression
Published in PLoS genetics (01-01-2018)“…The HLA-C gene appears to have evolved in higher primates to serve as a dominant source of ligands for the KIR2D family of inhibitory MHC class I receptors…”
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T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection
Published in Cell reports (Cambridge) (14-01-2020)“…Human rhinoviruses cause the common cold and exacerbate chronic respiratory diseases. Although infection elicits neutralizing antibodies, these do not persist…”
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Tuning of NK-Specific HLA-C Expression by Alternative mRNA Splicing
Published in Frontiers in immunology (10-01-2020)“…A complex system regulating HLA-C expression in NK cells, driven by an NK-specific promoter that produces alternatively spliced variants of the 5'-UTR has been…”
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Monitoring Circulating Virus-Specific CD4+ T Cells and Probiotic Effect in an Experimental Rhinovirus Challenge Model
Published in Journal of allergy and clinical immunology (01-02-2016)“…Pre-existing RV-specific memory cells recognized epitopes conserved across RV strains, comprised a mixture of T helper (CXCR5neg) and T follicular helper…”
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Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a proallergic milieu
Published in Journal of allergy and clinical immunology (01-11-2010)“…Background Thymic stromal lymphopoietin (TSLP) is expressed at sites of allergic inflammation, including eczematous skin. This cytokine has been reported to…”
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The KIR2DL1 intermediate upstream element participates in gene activation
Published in Immunogenetics (New York) (01-12-2023)“…The human KIR genes encode a family of class I MHC receptors that are expressed on subsets of NK cells. The expression of KIR proteins is controlled by a…”
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Split Euler Tours In 4-Regular Planar Graphs
Published in Discussiones Mathematicae. Graph Theory (01-01-2016)“…The construction of a homing tour is known to be NP-complete. On the other hand, the Euler formula puts su cient restrictions on plane graphs that one should…”
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Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma
Published in Journal of allergy and clinical immunology (01-09-2020)“…Allergic asthmatic subjects are uniquely susceptible to acute wheezing episodes provoked by rhinovirus. However, the underlying immune mechanisms and…”
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Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans
Published in The Journal of infectious diseases (17-01-2018)“…Circulating virus-specific CCR5+ effector memory CD4+ T cells primed by past exposures to related viruses (1) respond rapidly to rhinovirus and (2) contribute…”
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Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2
Published in The Journal of biological chemistry (29-01-2016)“…Bla g 2 is a major indoor cockroach allergen associated with the development of asthma. Antigenic determinants on Bla g 2 were analyzed by mutagenesis based on…”
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Rhinovirus Infection Induces Dual Amplification of Virus- and Allergen-Specific T Cells with Discrete Phenotypes in Allergic Asthmatics
Published in Journal of allergy and clinical immunology (01-02-2017)“…Analysis of lineage-specifying transcription factors in T cells by mass cytometry revealed a major population of memory CD4+ T cells that co-expressed T-bet…”
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Flow cytometry imaging identifies rare T(H)2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu
Published in Journal of allergy and clinical immunology (01-11-2010)“…Thymic stromal lymphopoietin (TSLP) is expressed at sites of allergic inflammation, including eczematous skin. This cytokine has been reported to exert its…”
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Structure, properties, and tissue localization of apoplastic alpha-glucosidase in crucifers
Published in Plant physiology (Bethesda) (01-02-1999)“…Apoplastic alpha-glucosidases occur widely in plants but their function is unknown because appropriate substrates in the apoplast have not been identified…”
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Identification of Probabilistic Transcriptional Switches in the Ly49 Gene Cluster: A Eukaryotic Mechanism for Selective Gene Activation
Published in Immunity (Cambridge, Mass.) (01-07-2004)“…Murine natural killer cells selectively express members of the Ly49 family of class I MHC receptors; however, the molecular mechanism controlling probabilistic…”
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ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets
Published in Developmental biology (01-04-2003)“…Selected for its high relative abundance, a protein spot of MW ∼75 kDa, p I 5.5 was cored from a Coomassie-stained two-dimensional gel of proteins from 2850…”
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Identification and analysis of novel transcripts and promoters in the human killer cell immunoglobulin-like receptor (KIR) genes
Published in Methods in molecular biology (Clifton, N.J.) (2010)“…This chapter describes the techniques our lab has used to find the multiple promoters present in individual KIR genes. Our previous studies in the murine Ly49…”
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Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor
Published in Neuron (Cambridge, Mass.) (01-02-1994)“…mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain…”
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