Search Results - "Wright, Nathan T."

Calpain Regulation and Dysregulation-Its Effects on the Intercalated Disk by Yoder, Micah W, Wright, Nathan T, Borzok, Maegen A

“…The intercalated disk is a cardiac specific structure composed of three main protein complexes-adherens junctions, desmosomes, and gap junctions-that work in…”
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Biophysical characterization of naturally occurring titin M10 mutations by Rudloff, Michael W., Woosley, Alec N., Wright, Nathan T.

“…The giant proteins titin and obscurin are important for sarcomeric organization, stretch response, and sarcomerogenesis in myofibrils. The extreme C‐terminus…”
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A novel FLNC frameshift and an OBSCN variant in a family with distal muscular dystrophy by Rossi, Daniela, Palmio, Johanna, Evilä, Anni, Galli, Lucia, Barone, Virginia, Caldwell, Tracy A, Policke, Rachel A, Aldkheil, Esraa, Berndsen, Christopher E, Wright, Nathan T, Malfatti, Edoardo, Brochier, Guy, Pierantozzi, Enrico, Jordanova, Albena, Guergueltcheva, Velina, Romero, Norma Beatriz, Hackman, Peter, Eymard, Bruno, Udd, Bjarne, Sorrentino, Vincenzo

“…A novel FLNC c.5161delG (p.Gly1722ValfsTer61) mutation was identified in two members of a French family affected by distal myopathy and in one healthy…”
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Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway by Ackermann, Maegen A., King, Brendan, Lieberman, Nicole A.P., Bobbili, Prameela J., Rudloff, Michael, Berndsen, Christopher E., Wright, Nathan T., Hecker, Peter A., Kontrogianni-Konstantopoulos, Aikaterini

“…The intercalated disc of cardiac muscle embodies a highly-ordered, multifunctional network, essential for the synchronous contraction of the heart. Over 200…”
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Case Report: Two Families With HPDL Related Neurodegeneration by Micule, Ieva, Lace, Baiba, Wright, Nathan T, Chrestian, Nicolas, Strautmanis, Jurgis, Diriks, Mikus, Stavusis, Janis, Kidere, Dita, Kleina, Elfa, Zdanovica, Anna, Laflamme, Nataly, Rioux, Nadie, Setty, Samarth Thonta, Pajusalu, Sander, Droit, Arnaud, Lek, Monkol, Rivest, Serge, Inashkina, Inna

“…There are recent reports of associations of variants in the gene with a hereditary neurological disease that presents with a wide spectrum of clinical…”
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Structural Insights on the Obscurin-Binding Domains in Titin by Letourneau, Allyn G, Wright, Nathan T

“…The giant muscular proteins titin and obscurin bind to each other at the Zdisk during muscle development. This binding event is mediated through two domains…”
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S100A1 and Calmodulin Compete for the Same Binding Site on Ryanodine Receptor by Wright, Nathan T., Prosser, Benjamin L., Varney, Kristen M., Zimmer, Danna B., Schneider, Martin F., Weber, David J.

“…In heart and skeletal muscle an S100 protein family member, S100A1, binds to the ryanodine receptor (RyR) and promotes Ca2+ release. Using competition binding…”
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Bringing biophysics outreach to a county fair by Wright, Nathan T.

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Overlapping Motifs (PTAP and PPEY) within the Ebola Virus VP40 Protein Function Independently as Late Budding Domains: Involvement of Host Proteins TSG101 and VPS-4 by Licata, Jillian M, Simpson-Holley, Martha, Wright, Nathan T, Han, Ziying, Paragas, Jason, Harty, Ronald N

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Microscopic springs: Investigating viscoelastic and elastic tendencies of the cell membrane by Sedley, Alexander, Miller, Callie, Wright, Nathan T.

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S100A1 Binds to the Calmodulin-binding Site of Ryanodine Receptor and Modulates Skeletal Muscle Excitation-Contraction Coupling by Prosser, Benjamin L., Wright, Nathan T., Hernãndez-Ochoa, Erick O., Varney, Kristen M., Liu, Yewei, Olojo, Rotimi O., Zimmer, Danna B., Weber, David J., Schneider, Martin F.

“…S100A1, a 21-kDa dimeric Ca2+-binding protein, is an enhancer of cardiac Ca2+ release and contractility and a potential therapeutic agent for the treatment of…”
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Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement by Buller, Andrew R., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.

“…ThnT is a pantetheine hydrolase from the DmpA/OAT superfamily involved in the biosynthesis of the ß-lactam antibiotic thienamycin. We performed a structural…”
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Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis by Buller, Andrew R., Labonte, Jason W., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.

“…cis-Autoproteolysis is a post-translational modification necessary for the function of ThnT, an enzyme involved in the biosynthesis of the β-lactam antibiotic…”
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Quantifying obscurin's impact on epithelial cell area, perimeter & localization with the cell membrane by Ong, Mason F., Miller, Callie, Wright, Nathan T.

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I told you to stop: obscurin's role in epithelial cell migration by Shultz, Kamrin D, Al Anbari, Yasmin F, Wright, Nathan T

“…The giant cytoskeletal protein obscurin contains multiple cell signaling domains that influence cell migration. Here, we follow each of these pathways, examine…”
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Investigating obscurin's modulation through the RhoA pathway by Harkrider, Quinn C., Shultz, Kamrin D., Wright, Nathan T.

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Bandaids on broken hearts: Preventing protease-mediated degradation of desmoplakin with small molecules by Nowzari, Roujon A., Romov, Isabel M., Wright, Nathan T.

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Compound heterozygous variants in MYBPC1 lead to severe distal arthrogryposis type-1 manifestations by Iyer, Aishwarya, Lauerova, Barbora, Mariano, Jennifer, Haberlová, Jana, Lassuthova, Petra, Zidkova, Jana, Wright, Nathan T., Kontrogianni-Konstantopoulos, Aikaterini

“…•MYBPC1 is an emerging myopathic gene associated with severe and lethal forms of arthrogryposis multiplex congenita syndromes.•Two novel compound heterozygous…”
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A Perspective on Developing Modeling and Image Analysis Tools to Investigate Mechanosensing Proteins by Ouderkirk, Stephanie, Sedley, Alex, Ong, Mason, Shifflet, Mary Ruth, Harkrider, Quinn C, Wright, Nathan T, Miller, Callie J

“…Synopsis The shift of funding organizations to prioritize interdisciplinary work points to the need for workflow models that better accommodate…”
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Heteronuclear Multidimensional Protein NMR in a Teaching Laboratory by Wright, Nathan T

“…Heteronuclear multidimensional NMR techniques are commonly used to study protein structure, function, and dynamics, yet they are rarely taught at the…”
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