Search Results - "Wright, NA"

Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms by Wright, N A, Poulsom, R

“…Bjerkes and colleagues 24 found crypts harbouring cells staining both positively and negatively for APC protein in FAP although these were not spatially…”
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Aspects of the biology of regeneration and repair in the human gastrointestinal tract by Wright, Nicholas A.

“…The main pathways of epithelial differentiation in the intestine, Paneth, mucous, endocrine and columnar cell lineages are well recognized. However, in…”
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Stem cells and cancer: an intimate relationship by Burkert, J, Wright, NA, Alison, MR

“…Tumour‐wide ‘omics’ approaches have long held sway as the approach to identifying useful therapeutic targets. This view is changing with the realization that…”
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development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse by Preston, SL, Leedham, SJ, Oukrif, D, Deheregoda, M, Goodlad, RA, Poulsom, R, Alison, MR, Wright, NA, Novelli, M

“…The morphological changes associated with the adenoma-carcinoma sequence are well documented in the colorectum. Small intestinal carcinogenesis is thought to…”
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Gastric stem cells: an update by Modlin, Irvin M., Kidd, Mark, Lye, Kevin D., NA, Wright

“…Cells of the gastric mucosa undergo constant renewal, the rate depending on the health of the tissue (inflammation, ulceration, carcinogenesis). While much…”
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Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice by Bamba, S, Lee, C-Y, Brittan, M, Preston, SL, Direkze, NC, Poulsom, R, Alison, MR, Wright, NA, Otto, WR

“…The authors have previously reported the derivation of colonic subepithelial myofibroblasts (SEMFs) in both humans and mice from bone marrow (BM). In the…”
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Reduced Shh expression in TFF2-overexpressing lesions of the gastric fundus under hypochlorhydric conditions by Minegishi, Y, Suzuki, H, Arakawa, M, Fukushima, Y, Masaoka, T, Ishikawa, T, Wright, NA, Hibi, T

“…Expression of sonic hedgehog (Shh), a morphogen for the gastric fundic glands, is reduced in the atrophic mucosa that develops in association with Helicobacter…”
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STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT by Brittan, M, Wright, N A

“…[...]adult stem cell plasticity has recently been disparaged by reports suggesting that stem cells spontaneously fuse with indigenous adult cells to form a…”
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Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts by DIREKZE, Natalie C, HODIVALA-DILKE, Kairbaan, JEFFERY, Rosemary, HUNT, Toby, POULSOM, Richard, OUKRIF, Dahmane, ALISON, Malcolm R, WRIGHT, Nicholas A

“…The role of myofibroblasts in tissue repair and fibrosis is well documented, but the source of these myofibroblasts is unclear. There is evidence of a…”
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A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis by Forbes, Stuart J., Russo, Francesco P., Rey, Virginia, Burra, Patrizia, Rugge, Massimo, Wright, Nicholas A., Alison, Malcolm R.

“…Background & aims: Myofibroblasts of bone marrow origin have recently been found in a number of parenchymal organs such as the gut and kidney. We have analyzed…”
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Side populations of gastrointestinal cancers are not enriched in stem cells by Burkert, J, Otto, WR, Wright, NA

“…The side population (SP) phenotype, defined as the reserpine-blockable ability to efflux the nucleic acid dye Hoechst 33342, has been claimed to be enriched…”
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Circulating mesenchymal stem cells by Roufosse, C.A, Direkze, N.C, Otto, W.R, Wright, N.A

“…Mesenchymal precursor cells (MPCs) are multipotent cells capable of differentiating into various mesenchymal tissues, such as bone, cartilage, fat, tendon and…”
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Gastrointestinal stem cells by Brittan, Mairi, Wright, Nicholas A.

“…Turnover of the epithelial cell lineages within the gastrointestinal tract is a constant process, occurring every 2–7 days under normal homeostasis and…”
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Skin Signs of Rheumatoid Arthritis and its Therapy-Induced Cutaneous Side Effects by Xue, Yun, Cohen, Jeffrey M., Wright, Natalie A., Merola, Joseph F.

“…Rheumatoid arthritis (RA) is a systemic inflammatory disorder that primarily affects the joints, but may exhibit extra-articular, including cutaneous,…”
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Mitochondrial DNA Mutations Are Established in Human Colonic Stem Cells, and Mutated Clones Expand by Crypt Fission by Greaves, Laura C., Preston, Sean L., Tadrous, Paul J., Taylor, Robert W., Barron, Martin J., Oukrif, Dahmane, Leedham, Simon J., Deheragoda, Maesha, Sasieni, Peter, Novelli, Marco R., Jankowski, Janusz A. Z., Turnbull, Douglass M., Wright, Nicholas A., McDonald, Stuart A. C.

“…The understanding of the fixation of mutations within human tissues and their subsequent clonal expansion is a considerable problem, of which little is known…”
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Hepatocytes from non-hepatic adult stem cells by ALISON, M. R, POULSOM, R, JEFFERY, R, DHILLON, A. P, QUAGLIA, A, JACOB, J, NOVELLI, M, PRENTICE, G, WILLIAMSON, J, WRIGHT, N. A

“…Stem cells are undifferentiated long-lived cells that are capable of many rounds of division. Here we show that adult human liver cells can be derived from…”
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Review article: is there a common principle in the development of gastrointestinal cancers? Stem cells in the origin of cancer by WRIGHT, N. A.

“…Summary Background Accumulating evidence, outlined in this review, at last provides some elucidation of the orgin of gastrointestinal epithelial tumours…”
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Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury by FANG, Te-Chao, ALISON, Malcolm R, COOK, H. Terence, JEFFERY, Rosemary, WRIGHT, Nicholas A, POULSOM, Richard

“…Studies of tissue from recipients of bone marrow transplantation or organ allograft suggest that bone marrow-derived cells (BMDC) may differentiate into a…”
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Bone marrow contributes to renal parenchymal turnover and regeneration by Poulsom, Richard, Forbes, Stuart J., Hodivala-Dilke, Kairbaan, Ryan, Eoin, Wyles, Susannah, Navaratnarasah, Sobana, Jeffery, Rosemary, Hunt, Toby, Alison, Malcolm, Cook, Terence, Pusey, Charles, Wright, Nicholas A.

“…In order to establish whether extra‐renal cells contribute to the turnover and repair of renal tissues, this study examined kidneys of female mice that had…”
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A Regenerative Role for Bone Marrow Following Experimental Colitis: Contribution to Neovasculogenesis and Myofibroblasts by Brittan, Mairi, Chance, Victoria, Elia, George, Poulsom, Richard, Alison, Malcolm R., MacDonald, Thomas T., Wright, Nicholas A.

“…Background & Aims: Bone marrow (BM) cells form differentiated adult lineages within nonhematopoietic tissues, with a heightened propensity with increasing…”
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