Search Results - "Wright, Madison T."

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics by Wright, Madison T, Timalsina, Bibek, Garcia Lopez, Valeria, Hermanson, Jake N, Garcia, Sarah, Plate, Lars

“…Many cellular processes are governed by protein–protein interactions that require tight spatial and temporal regulation. Accordingly, it is necessary to…”
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Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry by Munden, Alexander, Wright, Madison T., Han, Dongsheng, Tirgar, Reyhaneh, Plate, Lars, Nordman, Jared T.

“…Replication of the eukaryotic genome requires the formation of thousands of replication forks that must work in concert to accurately replicate the genetic and…”
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Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS by Rozas, Pablo, Pinto, Cristina, Martínez Traub, Francisca, Díaz, Rodrigo, Pérez, Viviana, Becerra, Daniela, Ojeda, Patricia, Ojeda, Jorge, Wright, Madison T, Mella, Jessica, Plate, Lars, Henríquez, Juan Pablo, Hetz, Claudio, Medinas, Danilo B

“…Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have…”
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Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis by Wright, Madison T., Kouba, Logan, Plate, Lars

“…Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones. Many characterized Tg gene mutations…”
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Revealing functional insights into ER proteostasis through proteomics and interactomics by Wright, Madison T., Plate, Lars

“…The endoplasmic reticulum (ER), responsible for processing approximately one-third of the human proteome including most secreted and membrane proteins, plays a…”
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Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22 by Marinko, Justin T., Wright, Madison T., Schlebach, Jonathan P., Clowes, Katherine R., Heintzman, Darren R., Plate, Lars, Sanders, Charles R.

“…Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior…”
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Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase by Reisman, Benjamin J., Guo, Hui, Ramsey, Haley E., Wright, Madison T., Reinfeld, Bradley I., Ferrell, P. Brent, Sulikowski, Gary A., Rathmell, W. Kimryn, Savona, Michael R., Plate, Lars, Rubinstein, John L., Bachmann, Brian O.

“…Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their…”
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Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis by Bilches Medinas, Danilo, Malik, Sajid, Yıldız‐Bölükbaşı, Esra, Borgonovo, Janina, Saaranen, Mirva J, Urra, Hery, Pulgar, Eduardo, Afzal, Muhammad, Contreras, Darwin, Wright, Madison T, Bodaleo, Felipe, Quiroz, Gabriel, Rozas, Pablo, Mumtaz, Sara, Díaz, Rodrigo, Rozas, Carlos, Cabral‐Miranda, Felipe, Piña, Ricardo, Valenzuela, Vicente, Uyan, Ozgun, Reardon, Christopher, Woehlbier, Ute, Brown, Robert H, Sena‐Esteves, Miguel, Gonzalez‐Billault, Christian, Morales, Bernardo, Plate, Lars, Ruddock, Lloyd W, Concha, Miguel L, Hetz, Claudio, Tolun, Aslıhan

“…Recessive gene mutations underlie many developmental disorders and often lead to disabling neurological problems. Here, we report identification of a…”
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Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis by Wright, Madison T, Kouba, Logan, Plate, Lars

“…Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for T3 and T4 hormones. Many characterized Tg gene mutations produce…”
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