Search Results - "Wright, Kenneth L."

Histone deacetylase 8 inhibition suppresses mantle cell lymphoma viability while preserving natural killer cell function by Watters, January M., Wright, Gabriela, Smith, Matthew A., Shah, Bijal, Wright, Kenneth L.

“…Mantle Cell Lymphoma (MCL) is a non-Hodgkin lymphoma with a median survival rate of five years. Standard treatment with high-dose chemotherapy plus rituximab…”
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The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance by Villagra, Alejandro, Sotomayor, Eduardo M, Cheng, Fengdong, Wang, Hong-Wei, Suarez, Ildelfonso, Glozak, Michelle, Maurin, Michelle, Nguyen, Danny, Wright, Kenneth L, Atadja, Peter W, Bhalla, Kapil, Pinilla-Ibarz, Javier, Seto, Edward

“…Interleukin 10 dampens inflammation and prevents excessive tissue damage during immune responses. Sotomayor and colleagues show that the histone deacetylase…”
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Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters by Reusch, Jessica A, Nawandar, Dhananjay M, Wright, Kenneth L, Kenney, Shannon C, Mertz, Janet E

“…Epstein-Barr virus (EBV) maintains a lifelong latent infection within a subset of its host's memory B cells, while lytic EBV replication takes place in plasma…”
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HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms by Yue, Lanzhu, Sharma, Vasundhara, Horvat, Nathan P., Akuffo, Afua A., Beatty, Matthew S., Murdun, Cem, Colin, Christelle, Billington, Julia M.R., Goodheart, William E., Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia N., Pinilla-Ibarz, Javier, Reuther, Gary W., Wright, Kenneth L., Conti, Chiara, Lee, Jennifer Y., Zheng, Xiaozhang, Ng, Pui Yee, Martin, Matthew W., Marshall, C. Gary, Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo M., Shao, Zonghong, Epling-Burnette, Pearlie K.

“…Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6 (HDAC6) controls JAK2 translation and protein stability and has…”
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Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms by Sharma, Vasundhara, Wright, Kenneth L, Epling-Burnette, Pearlie K, Reuther, Gary W

“…The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic…”
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Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes by Ward, Grace A, Dalton, 3rd, Robert P, Meyer, Benjamin S, McLemore, Amy F, Aldrich, Amy L, Lam, Nghi B, Onimus, Alexis H, Vincelette, Nicole D, Trinh, Thu Le, Chen, Xianghong, Calescibetta, Alexandra R, Christiansen, Sean M, Hou, Hsin-An, Johnson, Joseph O, Wright, Kenneth L, Padron, Eric, Eksioglu, Erika A, List, Alan F

“…Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome…”
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Role of Stat3 in Regulating p53 Expression and Function by Niu, Guilian, Wright, Kenneth L., Ma, Yihong, Wright, Gabriela M., Huang, Mei, Irby, Rosalyn, Briggs, Jon, Karras, James, Cress, W. Douglas, Pardoll, Drew, Jove, Richard, Chen, Jiangdong, Yu, Hua

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC by Dalton, Robert, Calescibetta, Alexandra, Zhou, Jun Min, Maurin, Michelle, Ward, Grace, Trinh, Thu Le, Tu, Nhan, Gilvary, Danielle, Chen, Xianghong, Cheng, Pingyan, Kostenko, Elena, Wei, Sheng, Wright, Kenneth L, Eksioglu, Erika A

“…Dendritic cells (DCs) are professional antigen presenting cells with a great capacity for cross-presentation of exogenous antigens from which robust anti-tumor…”
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PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing by Gy ry, Ildikó, Wu, Jian, Wright, Kenneth L, Fejér, György, Seto, Edward

“…PRDI-BF1, the human ortholog of mouse Blimp-1, is a DNA-binding protein involved in postinduction repression of interferon-beta gene transcription in response…”
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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis by GUILIAN NIU, WRIGHT, Kenneth L, HELLER, Richard, ELLIS, Lee M, KARRAS, James, BROMBERG, Jacqueline, PARDOLL, Drew, JOVE, Richard, YU, Hua, MEI HUANG, LANXI SONG, HAURA, Eric, TURKSON, James, SHUMIN ZHANG, TIANHONG WANG, SINIBALDI, Dominic, COPPOLA, Domenico

“…Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are major inducers of vascular endothelial growth factor (VEGF), one of the…”
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CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies by Trinh, ThuLe, Adams, William A., Calescibetta, Alexandra, Tu, Nhan, Dalton, Robert, So, Tina, Wei, Max, Ward, Grace, Kostenko, Elena, Christiansen, Sean, Cen, Ling, McLemore, Amy, Reed, Kayla, Whitting, Junmin, Gilvary, Danielle, Blanco, Neale Lopez, Segura, Carlos Moran, Nguyen, Jonathan, Kandell, Wendy, Chen, Xianghong, Cheng, Pingyan, Wright, Gabriela M., Cress, W. Douglas, Liu, Jinghong, Wright, Kenneth L., Wei, Sheng, Eksioglu, Erika A.

“…Advances in the understanding of the tumor microenvironment have led to development of immunotherapeutic strategies, such as chimeric antigen receptor T cells…”
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Positive Regulatory Domain I (PRDM1) and IRF8/PU.1 Counter-regulate MHC Class II Transactivator (CIITA) Expression during Dendritic Cell Maturation by Smith, Matthew A., Wright, Gabriela, Wu, Jian, Tailor, Prafullakumar, Ozato, Keiko, Chen, Xianghong, Wei, Sheng, Piskurich, Janet F., Ting, Jenny P.-Y., Wright, Kenneth L.

“…Dendritic cells (DCs) are key mediators of immune function through robust and tightly regulated presentation of antigen in the context of the MHC Class II. MHC…”
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MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output by Chen, Lihong, Li, Zhenyu, Zwolinska, Aleksandra K, Smith, Matthew A, Cross, Brittany, Koomen, John, Yuan, Zhi-Min, Jenuwein, Thomas, Marine, Jean-Christophe, Wright, Kenneth L, Chen, Jiandong

“…MDM2 is a key regulator of the p53 tumor suppressor acting primarily as an E3 ubiquitin ligase to promote its degradation. MDM2 also inhibits p53…”
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Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma by Mostofa, Agm, Distler, Allison, Meads, Mark B, Sahakian, Eva, Powers, John J, Achille, Alexandra, Noyes, David, Wright, Gabriela, Fang, Bin, Izumi, Victoria, Koomen, John, Rampakrishnan, Rupal, Nguyen, Tuan P, De Avila, Gabriel, Silva, Ariosto S, Sudalagunta, Praneeth, Canevarolo, Rafael Renatino, Siqueira Silva, Maria D Coelho, Alugubelli, Raghunandan Reddy, Dai, Hongyue A, Kulkarni, Amit, Dalton, William S, Hampton, Oliver A, Welsh, Eric A, Teer, Jamie K, Tungesvik, Alexandre, Wright, Kenneth L, Pinilla-Ibarz, Javier, Sotomayor, Eduardo M, Shain, Kenneth H, Brayer, Jason

“…The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and…”
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How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene by Chatterjee-Kishore, Moitreyee, Wright, Kenneth L., Ting, Jenny P.-Y., Stark, George R.

“…Analysis of mRNA levels in cells that express or lack signal transducers and activators of transcription 1 (Stat1) reveals that Stat1 mediates the constitutive…”
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PRDM1 is required for mantle cell lymphoma response to bortezomib by Desai, Shruti, Maurin, Michelle, Smith, Matthew A, Bolick, Sophia C E, Dessureault, Sophie, Tao, Jianguo, Sotomayor, Eduardo, Wright, Kenneth L

“…Mantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma with a poor disease-free survival rate. The proteasome inhibitor bortezomib is approved for…”
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Identification of a Functionally Impaired Positive Regulatory Domain I Binding Factor 1 Transcription Repressor in Myeloma Cell Lines by Gyory, Ildiko, Fejer, Gyorgy, Ghosh, Nilanjan, Seto, Ed, Wright, Kenneth L

“…B cell differentiation into a plasma cell requires expression of the positive regulatory domain zinc finger protein 1 gene (PRDM1) that encodes the positive…”
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PU.1 Regulates Positive Regulatory Domain I-Binding Factor 1/Blimp-1 Transcription in Lymphoma Cells by Desai, Shruti, Bolick, Sophia C. E, Maurin, Michelle, Wright, Kenneth L

“…The human positive regulatory domain I-binding factor 1 (PRDI-BF1) and its murine homolog Blimp-1 promote differentiation of mature B cells into Ab-secreting…”
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Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas by Zhang, Xinwei, Zhao, Xiaohong, Fiskus, Warren, Lin, Jianhong, Lwin, Tint, Rao, Rekha, Zhang, Yizhuo, Chan, John C, Fu, Kai, Marquez, Victor E, Chen-Kiang, Selina, Moscinski, Lynn C, Seto, Edward, Dalton, William S, Wright, Kenneth L, Sotomayor, Eduardo, Bhalla, Kapil, Tao, Jianguo

“…We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We…”
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Immunodepletion of MDSC by AMV564, a novel bivalent, bispecific CD33/CD3 T cell engager, ex vivo in MDS and melanoma by Cheng, Pingyan, Chen, Xianghong, Dalton, Robert, Calescibetta, Alexandra, So, Tina, Gilvary, Danielle, Ward, Grace, Smith, Victoria, Eckard, Sterling, Fox, Judith A., Guenot, Jeanmarie, Markowitz, Joseph, Cleveland, John L., Wright, Kenneth L., List, Alan F., Wei, Sheng, Eksioglu, Erika A.

“…We have reported previously that CD33hi myeloid-derived suppressor cells (MDSCs) play a direct role in the pathogenesis of myelodysplastic syndromes (MDSs) and…”
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