Search Results - "Wright, Kendra N."

Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts by Ferrario, Carlos M, VonCannon, Jessica, Ahmad, Sarfaraz, Wright, Kendra N, Roberts, Drew J, Wang, Hao, Yamashita, Tomohisa, Groban, Leanne, Cheng, Che Ping, Collawn, James F, Dell'Italia, Louis J, Varagic, Jasmina

“…Angiotensin-(1-12) [Ang-(1-12)], an alternate substrate for tissue angiotensin II (Ang II) formation, underscores the importance of alternative…”
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Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases by Wang, Hao, Varagic, Jasmina, Nagata, Sayaka, Kon, Neal D., Ahmad, Sarfaraz, VonCannon, Jessica L., Wright, Kendra N., Sun, Xuming, Deal, Dwight, Groban, Leanne, Ferrario, Carlos M.

“…The data presented here are related to the research article entitled “Differential expression of the angiotensin-(1-12) [Ang-(1-12)]/chymase axis in human…”
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Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1–12) substrate by Ahmad, Sarfaraz, Wright, Kendra N., Sun, Xuming, Groban, Leanne, Ferrario, Carlos M.

“…Angiotensin processing peptidases (carboxypeptidase A (CPA) and chymase) are stored in cardiac mast cell (MC) secretory granules in large quantity and are…”
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The Angiotensin-(1–12)/Chymase axis as an alternate component of the tissue renin angiotensin system by Ferrario, Carlos M., Groban, Leanne, Wang, Hao, Cheng, Che Ping, VonCannon, Jessica L, Wright, Kendra N., Sun, Xuming, Ahmad, Sarfaraz

“…The identification of an alternate extended form of angiotensin I composed of the first twelve amino acids at the N-terminal of angiotensinogen has generated…”
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Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension by Ferrario, Carlos M., VonCannon, Jessica L., Zhang, Jie, Figueroa, Jorge P., Wright, Kendra N., Groban, Leanne, Saha, Amit, Meredith, J. Wayne, Ahmad, Sarfaraz

“…[Display omitted] •Ang-(1–12) is an endogenous Ang II-forming substrate that contributes to the maintenance of arterial pressure.•Immunoneutralization of human…”
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The renin-angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts by Ferrario, Carlos M, Groban, Leanne, Wang, Hao, Sun, Xuming, VonCannon, Jessica L, Wright, Kendra N, Ahmad, Sarfaraz

“…A large body of evidence implicates the renin-angiotensin system in the pathogenesis of cardiovascular disease. However, not everyone understands that the…”
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Internalization of Angiotensin‐(1‐12) in Adult Retinal Pigment Epithelial‐19 Cells by Ahmad, Sarfaraz, Wright, Kendra N., Ferrario, Carlos M., Cheng, Heng‐Jie, Choudhary, Mayur, Malek, Goldis, Sappington, Rebecca M.

“…Introduction The characterization, by this laboratory, of angiotensin‐(1‐12) [Ang‐(1‐12)] as a primary angiotensin II (Ang II)‐forming substrate may be an…”
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Angiotensin (1–12) in Humans With Normal Blood Pressure and Primary Hypertension by Ferrario, Carlos M., Iyer, Seethalakshmi R., Burnett, John C., Ahmad, Sarfaraz, Wright, Kendra N., VonCannon, Jessica L., Saha, Amit, Groban, Leanne

“…The importance of canonical versus noncanonical mechanisms for the generation of angiotensins remains a major challenge that, in part, is heavily swayed by the…”
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Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats by Sun, Xuming, Wang, Hao, Hodge, Hunter, Wright, Kendra N., Ahmad, Sarfaraz, Ferrario, Carlos M., Groban, Leanne

“…G protein-coupled estrogen receptor (GPER) activation by G1 attenuates diastolic dysfunction from estrogen loss, which may be partly due to suppression of…”
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Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage Cells by Yamashita, Tomohisa, Ahmad, Sarfaraz, Wright, Kendra N., Roberts, Drew J., VonCannon, Jessica L., Wang, Hao, Groban, Leanne, Dell’Italia, Louis J., Ferrario, Carlos M.

“…Bone marrow (BM) Ang II (angiotensin II) is a major participant in the regulation of hematopoiesis and immunity. The novel tissue substrate Ang-(1–12)…”
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Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue by Wang, Hao, Varagic, Jasmina, Nagata, Sayaka, Kon, Neal D., Ahmad, Sarfaraz, VonCannon, Jessica L., Wright, Kendra N., Sun, Xuming, Deal, Dwight, Groban, Leanne, Ferrario, Carlos M.

“…Heart chymase rather than angiotensin (Ang)-converting enzyme has higher specificity for Ang I conversion into Ang II in humans. A new pathway for direct…”
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Internalization of Angiotensin-(1-12) in Adult Retinal Pigment Epithelial-19 Cells by Ahmad, Sarfaraz, Wright, Kendra N, VonCannon, Jessica L, Ferrario, Carlos M, Ola, Mohammad S, Choudhary, Mayur, Malek, Goldis, Gustafson, Jenna R, Sappington, Rebecca M

“…Angiotensin-(1-12) [Ang-(1-12)] serves as a primary substrate to generate angiotensin II (Ang II) by angiotensin-converting enzyme and/or chymase suggests it…”
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Angiotensin-(1–12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen by Reyes, Santiago, Cheng, Che Ping, Roberts, Drew J., Yamashita, Tomohisa, Ahmad, Sarfaraz, VonCannon, Jessica L., Wright, Kendra N., Dell’Italia, Louis J., Varagic, Jasmina, Ferrario, Carlos M.

“…Activation of the intracrine renin angiotensin systems (RAS) is increasingly recognized as contributing to human pathologies, yet non-canonical…”
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Newly developed radioimmunoassay for Human Angiotensin-(1–12) measurements in plasma and urine by Ahmad, Sarfaraz, Punzi, Henry A., Wright, Kendra N., Groban, Leanne, Ferrario, Carlos M.

“…The dodecapeptide angiotensin-(1–12) [Ang-(1–12)] functions as an intracrine/paracrine substrate for local production of angiotensin II. We developed a…”
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Human Angiotensin‐(1‐12) [Ang‐(1‐12)] is a Hypertension and Cardiac Disease Biomarker by Ferrario, Carlos Maria, Groban, Leanne, Iyer, Seethalakshmi R., Ahmad, Sarfaraz, Wright, Kendra N., Burnett, John C.

“…Abstract only Background Ang‐(1‐12) is a primary non‐renin dependent substrate for direct tissue angiotensin II (Ang II) formation by chymase. This discovery…”
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Abstract P2033: Rationale For A Novel Approach To Hypertension Treatment Based On Immuno-neutralization Of Angiotensin-(1-12) Catalytic Sites With A Polyclonal Antibody by Ahmad, Sarfaraz, Wright, Kendra N, Varagic, Jasmina, Groban, Leanne, Ferrario, Carlos M

“…Abstract only The biochemical pathways for the formation of biological active angiotensins continues to undergo significant revision with the demonstration of…”
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Mast Cell Peptidases (Carboxypeptidase A and Chymase)‐Mediated Hydrolysis of Human Angiotensin‐(1‐12) by Ahmad, Sarfaraz, Wright, Kendra N, Varagic, Jasmina, Groban, Leanne, Ferrario, Carlos M

“…Introduction Angiotensin processing peptidases [carboxypeptidase A (CPA) and chymase] are stored in cardiac mast cell secretory granules and are co‐released…”
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Angiotensin (1–12) in Humans With Normal Blood Pressure and Primary Hypertension by Ferrario, Carlos M., Iyer, Seethalakshmi R., Burnett, John C., Ahmad, Sarfaraz, Wright, Kendra N., VonCannon, Jessica L., Saha, Amit, Groban, Leanne

“…The importance of canonical versus noncanonical mechanisms for the generation of angiotensins remains a major challenge that, in part, is heavily swayed by the…”
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Equivalence of G1/GPER Monotherapy Compared with Dual Administration of G1 and Lisinopril in Preventing Diastolic Dysfunction due to Estrogen Loss in SHR by Sun, Xuming, Wright, Kendra N, Hodge, Hunter S, Ahmad, Sarfaraz, Varagic, Jasmina, Wang, Hao, Ferrario, Carlos M, Groban, Leanne

“…Introduction The increased prevalence of heart failure with preserved ejection fraction (HFpEF) in women after menopause is linked to estrogen…”
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Non-canonical Mechanisms for Direct Bone Marrow Generating Angiotensin II Predominate in CD68 Positive Myeloid Lineage Cells by Yamashita, Tomohisa, Ahmad, Sarfaraz, Wright, Kendra N., Roberts, Drew J., VonCannon, Jessica L., Wang, Hao, Groban, Leanne, Dell’Italia, Louis J., Ferrario, Carlos M.

“…Bone marrow (BM) angiotensin II is a major participant in the regulation of hematopoiesis and immunity. The novel tissue substrate angiotensin-(1–12) and its…”
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