Search Results - "Wright, Jon L"

3-Arylimino-2-indolones Are Potent and Selective Galanin GAL3 Receptor Antagonists by Konkel, Michael J, Lagu, Bharat, Boteju, Lakmal W, Jimenez, Hermogenes, Noble, Stewart, Walker, Mary W, Chandrasena, Gamini, Blackburn, Thomas P, Nikam, Sham S, Wright, Jon L, Kornberg, Brian E, Gregory, Tracy, Pugsley, Thomas A, Akunne, Hyacinth, Zoski, Kim, Wise, Lawrence D

“…A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example,…”
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Subtype-Selective N-Methyl-d-Aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines by Wright, Jon L, Gregory, Tracy F, Kesten, Suzanne R, Boxer, Peter A, Serpa, Kevin A, Meltzer, Leonard T, Wise, Lawrence D, Espitia, Stephen A, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M

“…4-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]phenol (8) and 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]phenol (9) are potent NR1a/2B receptor antagonists (IC50 values…”
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The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents by Wright, Jon L, Caprathe, Bradley W, Downing, Dennis M, Glase, Shelly A, Heffner, Thomas G, Jaen, Juan C, Johnson, Stephen J, Kesten, Suzanne R, MacKenzie, Robert G

“…A novel dopamine (DA) autoreceptor agonist, 1,2,3,6-tetrahydro-4-phenyl-1- [(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine (14), was identified. The…”
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Subtype selective NMDA receptor antagonists: evaluation of some novel alkynyl analogues by KORNBERG, Brian E, NIKAM, Sham S, WRIGHT, Jon L, KESTEN, Suzanne R, MELTZER, Leonard T, COUGHENOUR, Linda, BARR, Bridget, SERPA, Kevin A, MCCORMICK, Julie

“…A benzylpiperidine analogue with an acetylenic linker, 5-(3-[4-(4-fluorobenzyl)-piperidin-1-yl]-prop-1-ynyl)-1,3-dihydrobenzimidazol-2-one (3), was identified…”
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Synthesis of N-Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines:  Selective Antagonists at the 1a/2B NMDA Receptor Subtype by Guzikowski, Anthony P, Tamiz, Amir P, Acosta-Burruel, Manuel, Hong-Bae, Soo, Cai, Sui Xiong, Hawkinson, Jon E, Keana, John F. W, Kesten, Suzanne R, Shipp, Christina T, Tran, Minhtam, Whittemore, Edward R, Woodward, Richard M, Wright, Jon L, Zhou, Zhang-Lin

“…Antagonists at the 1a/2B subtype of the NMDA receptor (NR1a/2B) are typically small molecules that consist of a 4-benzyl- or a 4-phenylpiperidine with an…”
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Discovery of selective dopamine D4 receptor antagonists: 1-Aryloxy-3-(4-aryloxypiperidinyl)-2-propanols by Wright, Jon L., Gregory, Tracy F., Heffner, Thomas G., MacKenzie, Robert G., Pugsley, Thomas A., Meulen, Seth Vander, Wise, Lawrence D.

“…High volume screening identified 3-(4-benzylpiperidinyl)-1-naphthoxy-2-propanol as a selective dopamine D4 receptor ligand. A systematic structure-activity…”
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Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines by Wright, Jon L, Gregory, Tracy F, Bigge, Christopher F, Boxer, Peter A, Serpa, Kevin, Meltzer, Leonard T, Wise, Lawrence D, Cai, Sui Xiong, Hawkinson, Jon E, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M, Zhou, Zhang-Lin

“…A search of our compound library for compounds with structural similarity to ifenprodil (5) and haloperidol (7) followed by in vitro screening revealed that…”
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Identification, Characterization and Pharmacological Profile of Three Metabolites of (R)-(+)-1,2,3,6-Tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1-yl)methyl]p yridine (CI-1007), a Dopamine Autoreceptor Agonist and Potential Antipsychotic Agent by Wright, Jon L, Downing, Dennis M, Feng, M. Rose, Hayes, Roger N, Heffner, Thomas G, MacKenzie, Robert G, Meltzer, Leonard T, Pugsley, Thomas A, Wise, Lawrence D

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3-Arylimino-2-indolones Are Potent and Selective Galanin GAL 3 Receptor Antagonists by Konkel, Michael J., Lagu, Bharat, Boteju, Lakmal W., Jimenez, Hermogenes, Noble, Stewart, Walker, Mary W., Chandrasena, Gamini, Blackburn, Thomas P., Nikam, Sham S., Wright, Jon L., Kornberg, Brian E., Gregory, Tracy, Pugsley, Thomas A., Akunne, Hyacinth, Zoski, Kim, Wise, Lawrence D.

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3-arylimino-2-indolones are potent and selective galanin GAL3receptor antagonists by KONKEL, Michael J, LAGU, Bharat, KORNBERG, Brian E, GREGORY, Tracy, PUGSLEY, Thomas A, AKUNNE, Hyacinth, ZOSKI, Kim, WISE, Lawrence D, BOTEJU, Lakmal W, JIMENEZ, Hermogenes, NOBLE, Stewart, WALKER, Mary W, CHANDRASENA, Gamini, BLACKBURN, Thomas P, NIKAM, Sham S, WRIGHT, Jon L

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Discovery of subtype-selective NMDA receptor ligands : 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists by WRIGHT, J. L, GREGORY, T. F, WHITTEMORE, E. R, WOODWARD, R. M, YANG, K. C, ZHOU, Z.-L, BOXER, P. A, MELTZER, L. T, SERPA, K. A, WISE, L. D, HONG-BAE, S, HUANG, J. C, KONKOY, C. S, UPASANI, R. B

“…4-Benzyl-1-[4-(1H-imidazol-4-yl)but-3-ynyl]piperidine (8) has been identified as a potent antagonist of the NR1A/2B subtype of the NMDA receptor. When dosed…”
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Parallel synthesis of a series of subtype-selective NMDA receptor antagonists by GREGORY, T. F, WRIGHT, J. L, WISE, L. D, MELTZER, L. T, SERPA, K. A, KONKOY, C. S, WHITTEMORE, E. R, WOODWARD, R. M

“…A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for…”
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Synthesis of N- Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines:  Selective Antagonists at the 1 a /2B NMDA Receptor Subtype by Guzikowski, Anthony P., Tamiz, Amir P., Acosta-Burruel, Manuel, Hong-Bae, Soo, Cai, Sui Xiong, Hawkinson, Jon E., Keana, John F. W., Kesten, Suzanne R., Shipp, Christina T., Tran, Minhtam, Whittemore, Edward R., Woodward, Richard M., Wright, Jon L., Zhou, Zhang-Lin

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4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D3 receptor partial agonists by Glase, Shelly A., Akunne, Hyacinth C., Heffner, Thomas G., Johnson, Stephen J., Kesten, Suzanne R., MacKenzie, Robert G., Manley, Peter J., Pugsley, Thomas A., Wright, Jon L., Wise, Lawrence D.

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Pharmacological Characterization of PD 152255, a Novel Dimeric Benzimidazole Dopamine D 3 Antagonist by Corbin, Ann E, Pugsley, Thomas A, Akunne, Hyacinth C, Whetzel, Steven Z, Zoski, Kim T, Georgic, Lynn M, Nelson, Carrie B, Wright, Jon L, Wise, Lawrence D, Heffner, Thomas G

“…152255 ( E-1, 1′-(2-butene-1,4-diyl)bis [2-[4-[3-(1-piperidinyl)propoxy]-phenyl]-1H-benzimidazole]) exhibited high affinity ( K i = 12.7 nM) for human dopamine…”
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Pharmacological characterization of PD 152255, a novel dimeric benzimidazole dopamine D3 antagonist by CORBIN, A. E, PUGSLEY, T. A, AKUNNE, H. C, WHETZEL, S. Z, ZOSKI, K. T, GEORGIC, L. M, NELSON, C. B, WRIGHT, J. L, WISE, L. D, HEFFNER, T. G

“…152255 (E-1,1'-(2-butene-1,4-diyl)bis[2-[4-[3-(1-piperidinyl)propoxy]-phe nyl]-1H-benzimidazole]) exhibited high affinity (Ki = 12.7 nM) for human dopamine…”
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4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D 3 receptor partial agonists by Glase, Shelly A., Akunne, Hyacinth C., Heffner, Thomas G., Johnson, Stephen J., Kesten, Suzanne R., MacKenzie, Robert G., Manley, Peter J., Pugsley, Thomas A., Wright, Jon L., Wise, Lawrence D.

“…A series of 4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamide dopamine (DA) D 3 receptor agonists has been identified. These…”
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Discovery of subtype-selective NMDA receptor ligands: 4-Benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1 a/2B antagonists by Wright, Jon L., Gregory, Tracy F., Boxer, Peter A., Meltzer, Leonard T., Serpa, Kevin A., Wise, Lawrence D., Hong-Bae, Soo, Huang, Jin Cheng, Konkoy, Christopher S., Upasani, Ravindra B., Whittemore, Edward R., Woodward, Richard M., Yang, Kevin C., Zhou, Zhang-Lin

“…4-Benzyl-1-[4-(1 H -imidazol-4-yl)but-3-ynyl]piperidine ( 8) has been identified as a potent antagonist of the NR1 a/2B subtype of the NMDA receptor. When…”
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