Search Results - "Wright, Jeffrey L.C."

Regulation of spiroimine neurotoxins and hemolytic activity in laboratory cultures of the dinoflagellate Alexandrium peruvianum (Balech & Mendiola) Balech & Tangen by Tatters, Avery O., Van Wagoner, Ryan M., Wright, Jeffrey L.C., Tomas, Carmelo R.

“…► First study examining N:P ratios and toxin production by A. peruvianum. ► Detection of two spiroimine classes from a clonal dinoflagellate culture. ►…”
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Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications by Van Wagoner, Ryan M., Misner, Ian, Tomas, Carmelo R., Wright, Jeffrey L.C.

“…The novel gymnodimine congener 12-methylgymnodimine was isolated from the dinoflagellate Alexandrium peruvianum from the New River in North Carolina. In…”
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Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum by Van Wagoner, Ryan M., Deeds, Jonathan R., Satake, Masayuki, Ribeiro, Anthony A., Place, Allen R., Wright, Jeffrey L.C.

“…The karlotoxins (KmTxs) are a family of compounds produced by the dinoflagellate Karlodinium veneficum which cause membrane permeabilization. The structure of…”
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Structure and Biosynthesis of Amphidinol 17, a Hemolytic Compound from Amphidinium carterae by Meng, Yanhui, Van Wagoner, Ryan M, Misner, Ian, Tomas, Carmelo, Wright, Jeffrey L. C

“…Amphidinol 17 (AM17; 1), a novel amphidinol, has been isolated from a Bahamas strain of Amphidinium carterae. This new congener contains the signature hairpin…”
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Toxic Alexandrium peruvianum (Balech and de Mendiola) Balech and Tangen in Narragansett Bay, Rhode Island (USA) by Borkman, David G., Smayda, Theodore J., Tomas, Carmelo R., York, Robert, Strangman, Wendy, Wright, Jeffrey L.C.

“…► Toxic Alexandrium peruvianum is identified via morphology and molecular analysis from Narragansett Bay, RI, USA. ► First record in New England waters and…”
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Alexandrium peruvianum (Balech and Mendiola) Balech and Tangen a new toxic species for coastal North Carolina by Tomas, Carmelo R., van Wagoner, Ryan, Tatters, Avery O., White, Kevin D., Hall, Sherwood, Wright, Jeffrey L.C.

“…► Identifies for the first time A. peruvianum in North Carolina waters. ► Demonstrates the features that differentiate A. peruvianum and A. ostenfeldii. ►…”
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Flavones and flavone glycosides from Halophila johnsonii by Meng, Yanhui, Krzysiak, Amanda J., Durako, Michael J., Kunzelman, Jennifer I., Wright, Jeffrey L.C.

“…Chemical investigation of the shallow-water sea grass Halophila johnsonii yielded seven flavone glycosides together with three known flavone glycosides and…”
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Synthesis of the BC/DE ring model of brevisin for confirmation of the structure around the acyclic junction by Kuranaga, Takefumi, Satake, Masayuki, Baden, Daniel G., Wright, Jeffrey L.C., Tachibana, Kazuo

“…Synthesis of the BC/DE ring model of brevisin, a polycyclic ether isolated from the red tide dinoflagellate Karenia brevis, is reported. Comparison of the NMR…”
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Synthesis of a proposed biosynthetic intermediate of a marine cyclic ether brevisamide for study on biosynthesis of marine ladder-frame polyethers by Shirai, Tomohiro, Kuranaga, Takefumi, Wright, Jeffrey L.C., Baden, Daniel G., Satake, Masayuki, Tachibana, Kazuo

“…A proposed biosynthetic intermediate of brevisamide comprising a linear backbone with an E-olefin functionality was synthesized for biosynthetic studies on the…”
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Characterization of biologically inactive spirolides E and F: Identification of the spirolide pharmacophore by Hu, Tingmo, Curtis, Jonathan M., Walter, John A., Wright, Jeffrey L.C.

“…Two new spirolide derivatives, E and F, have been isolated in low yield from shellfish extracts. Absence of activity in the mouse bioassay of these…”
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Assignment of the relative stereochemistry of the spirolides, macrocyclic toxins isolated from shellfish and from the cultured dinoflagellate Alexandrium ostenfeldii by Falk, Michael, Burton, Ian W., Hu, Tingmo, Walter, John A., Wright, Jeffrey L.C.

“…The relative stereochemistry of 13-desmethyl spirolide C, except for one chiral center, has been determined from NMR data by means of ConGen, a molecular…”
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Exploring the diversity of marine-derived fungal polyketide synthases by Mayer, Kimberly M, Ford, Jermaine, Macpherson, Gordon R, Padgett, David, Volkmann-Kohlmeyer, Brigitte, Kohlmeyer, Jan, Murphy, Colleen, Douglas, Susan E, Wright, Jonathan M, Wright, Jeffrey L C

“…Using an approach based on polymerase chain reaction (PCR), we examined the diversity of polyketide synthase (PKS) genes present in 160 marine fungal isolates,…”
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Two new water-soluble dsp toxin derivatives from the dinoflagellate prorocentrum maculosum: possible storage and excretion products by Hu, Tingmo, Curtis, Jonathan M., Walter, John A., McLachlan, Jack L., Wright, Jeffrey L.C.

“…Two novel water-soluble sulfated DSP toxin derivatives 4 and 5, are reported from the benthic dinoflagellate Prorocentrum maculosum. Their occurrence supports…”
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Identification of the new chymotrypsin inhibitor micropeptin 996 by metabolomics-guided analysis by Strangman, Wendy K., Stewart, Allison K., Herring, Megan C., Wright, Jeffrey L.C.

“…[Display omitted] •Metabolomics-guided discovery of a new micropeptin cyanopeptide.•Comprehensive structure characterization.•Potent inhibition of…”
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Polyketide biosynthesis in dinoflagellates: what makes it different? by Van Wagoner, Ryan M, Satake, Masayuki, Wright, Jeffrey L C

“…Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been…”
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Microginins 680, 646, and 612—new chlorinated Ahoa-containing peptides from a strain of cultured Microcystis aeruginosa by Strangman, Wendy K., Wright, Jeffrey L.C.

“…[Display omitted] •New di-, mono-, and des-chlorinated microginins.•First example of chlorinated microginins containing rare Ahoa side chain.•Chemical…”
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Biosynthetic Studies of 13-Desmethylspirolide C Produced by Alexandrium ostenfeldii (= A. peruvianum): Rationalization of the Biosynthetic Pathway Following Incorporation of (13)C-Labeled Methionine and Application of the Odd-Even Rule of Methylation by Anttila, Matthew, Strangman, Wendy, York, Robert, Tomas, Carmelo, Wright, Jeffrey L C

“…Understanding the biosynthesis of dinoflagellate polyketides presents many unique challenges. Because of the remaining hurdles to dinoflagellate genome…”
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Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses by Lin, Shih-Chao, Lehman, Caitlin W., Stewart, Allison K., Panny, Lauren, Bracci, Nicole, Wright, Jeffrey L.C., Paige, Mikell, Strangman, Wendy K., Kehn-Hall, Kylene

“…Marine microorganisms have been a resource for novel therapeutic drugs for decades. In addition to anticancer drugs, the drug acyclovir, derived from a marine…”
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Metabolomics-Guided Discovery of Microginin Peptides from Cultures of the Cyanobacterium Microcystis aeruginosa by Stewart, Allison K, Ravindra, Rudravajhala, Van Wagoner, Ryan M, Wright, Jeffrey L. C

“…We report a mass-spectrometry-based metabolomics study of a laboratory-cultured strain of Microcystis aeruginosa (UTEX LB2385), which has led to the discovery…”
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Potent inhibitors of cysteine proteases from the marine fungus Microascus longirostris by Yu, C M, Curtis, J M, Walter, J A, Wright, J L, Ayer, S W, Kaleta, J, Querengesser, L, Fathi-Afshar, Z R

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