Search Results - "Wright, H S"

Computational Modeling to Accelerate the Identification of Substrates and Inhibitors for Transporters That Affect Drug Disposition by Ekins, S, Polli, J E, Swaan, P W, Wright, S H

“…We have seen an increased use of computational approaches to predicting drug interactions with human transporters that affect drug disposition and may lead to…”
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Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2 by CHENG, Y, WRIGHT, S. H, HOOTH, M. J, SIPES, I. G

“…Studies were conducted to characterize the effect of dose and route of administration on the disposition of N -butylpyridinium chloride (NBuPy-Cl), an ionic…”
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Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules by Soodvilai, S, Chatsudthipong, V, Evans, K K, Wright, S H, Dantzler, W H

“…We investigated the regulation of organic anion transport driven by the organic anion transporter 3 (OAT3), a multispecific OAT localized at the basolateral…”
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Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules by Soodvilai, S, Wright, S H, Dantzler, W H, Chatsudthipong, V

“…It was shown previously that OAT3 activity was differentially regulated by protein kinases including MAPK, PKA, and PKC. The present study investigated the…”
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The horizontal stability of a ball bouncing upon a vertically vibrated concave surface by Wright, H. S, Swift, M. R, King, P. J

“…In experiments a ball will not bounce repeatedly in the same place upon a vertically vibrating horizontal surface due to imperfections in the ball and the…”
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Constitutive secretion of the granule chymase mouse mast cell protease-1 and the chemokine, CCL2, by mucosal mast cell homologues by Brown, J. K., Knight, P. A., Wright, S. H., Thornton, E. M., Miller, H. R. P.

“…Summary Background The mucosal mast cell (MMC) granule‐specific β‐chymase, mouse mast cell protease‐1 (mMCP‐1), is released systemically into the bloodstream…”
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Interaction of the metal chelator 2,3-dimercapto-1-propanesulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1) by Bahn, A, Knabe, M, Hagos, Y, Rödiger, M, Godehardt, S, Graber-Neufeld, D S, Evans, K K, Burckhardt, G, Wright, S H

“…The metal chelator DMPS (2,3-dimercapto-1-propanesulfonate) is used to treat heavy metal intoxication because it increases renal excretion of these toxins,…”
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Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules by Lungkaphin, A, Chatsudthipong, V, Evans, K K, Groves, C E, Wright, S H, Dantzler, W H

“…2,3-Dimercapto-1-propanesulfonic acid (DMPS) is used clinically to increase urinary excretion of heavy metals, including mercury and arsenic. We used single S2…”
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pH and drug resistance. II. turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs by Raghunand, Natarajan, Martı́nez–Zaguilán, Raul, Wright, Stephen H, Gillies, Robert J

“…Resistance to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The primary mechanism leading to a multidrug-resistant…”
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The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules by Martínez-Guerrero, L J, Evans, K K, Dantzler, W H, Wright, S H

“…Secretion of organic cations (OCs) across renal proximal tubules (RPTs) involves basolateral OC transporter (OCT)2-mediated uptake from the blood followed by…”
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Mast cell heterogeneity in the gastrointestinal tract: variable expression of mouse mast cell protease-1 (mMCP-1) in intraepithelial mucosal mast cells in nematode-infected and normal BALB/c mice by Scudamore, CL, McMillan, L, Thornton, EM, Wright, SH, Newlands, GF, Miller, HR

“…Soluble granule chymases in rodent intestinal mucosal mast cells (IMMCs) may play an important role in altering epithelial permeability during immediate…”
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Purification and characterization of mouse mast cell proteinase-2 and the differential expression and release of mouse mast cell proteinase-1 and -2 in vivo by Pemberton, A. D., Brown, J. K., Wright, S. H., Knight, P. A., McPhee, M. L., McEuen, A. R., Forse, P. A., Miller, H. R.P.

“…Summary Background Gastrointestinal nematode infection is associated with mucosal mast cell (MMC) hyperplasia. In the mouse, this is accompanied by the release…”
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Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules by Dantzler, W H, Evans, K K, Wright, S H

“…Kinetics of the first 15 s of para-aminohippurate (PAH) uptake across the basolateral membrane of single isolated S2 segments of rabbit proximal renal tubules…”
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Peritubular organic cation transport in isolated rabbit proximal tubules by Groves, C E, Evans, K K, Dantzler, W H, Wright, S H

“…The physiological characteristics of peritubular organic cation transport were examined by measuring the transport of the organic cation tetraethylammonium…”
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Transport of tetraethylammonium by rabbit renal brush-border and basolateral membrane vesicles by Wright, S H, Wunz, T M

“…Brush-border and basolateral membrane vesicles (BBMV and BLMV, respectively) from rabbit renal cortex were used to study transport of the organic cation,…”
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Stochastic dynamics of a rod bouncing upon a vibrating surface by Wright, H S, Swift, Michael R, King, P J

“…We describe the behavior of a rod bouncing upon a horizontal surface which is undergoing sinusoidal vertical vibration. The predictions of computer simulations…”
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A novel tableted purgative for colonoscopic preparation: Efficacy and safety comparisons with Colyte and Fleet Phospho-Soda by Aronchick, Craig A., Lipshutz, William H., Wright, Scott H., Dufrayne, Francis, Bergman, Garrett

“…Background: Currently available aqueous purgatives used before colonoscopy are poorly tolerated. We designed a tableted sodium phosphate purge that we believe…”
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Migration of an asymmetric dimer in oscillatory fluid flow by Wright, H S, Swift, Michael R, King, P J

“…We describe the motion of an asymmetric dimer across a horizontal surface when exposed to an oscillatory fluid flow. The dimer consists of two spheres of…”
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Short-term cell volume regulation in Mytilus californianus gill by SILVA, A. L, WRIGHT, S. H

“…Long-term acclimation of Mytilus californianus to 60% artificial sea water (585 mosmol l-1; ASW) led to a 30-40% decrease in the taurine (53.5-36.9 mumol g-1…”
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Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1 by Knight, P A, Wright, S H, Lawrence, C E, Paterson, Y Y, Miller, H R

“…Expulsion of gastrointestinal nematodes is associated with pronounced mucosal mast cell (MMC) hyperplasia, differentiation, and activation, accompanied by the…”
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