Search Results - "Wright, Eric G."

Radiation and the microenvironment - tumorigenesis and therapy by Barcellos-Hoff, Mary Helen, Park, Catherine, Wright, Eric G

“…Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue…”
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Indirect Macrophage Responses to Ionizing Radiation : Implications for Genotype-Dependent Bystander Signaling by COATES, Philip J, RUNDLE, Jana K, LORIMORE, Sally A, WRIGHT, Eric G

“…In addition to the directly mutagenic effects of energy deposition in DNA, ionizing radiation is associated with a variety of untargeted and delayed effects…”
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Untargeted effects of ionizing radiation: implications for radiation pathology by Wright, Eric G, Coates, Philip J

“…The dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation,…”
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Responses to ionizing radiation mediated by inflammatory mechanisms by Mukherjee, Debayan, Coates, Philip J, Lorimore, Sally A, Wright, Eric G

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Chromosomal Instability in Unirradiated Hemaopoietic Cells Induced by Macrophages Exposed In vivo to Ionizing Radiation by LORIMORE, Sally A, CHRYSTAL, Jennifer A, ROBINSON, Joanne I, COATES, Philip J, WRIGHT, Eric G

“…The tumorigenic potential of ionizing radiation has conventionally been attributed to DNA damage in irradiated cells induced at the time of exposure. Recently,…”
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Bystander-Type Effects Mediated by Long-Lived Inflammatory Signaling in Irradiated Bone Marrow by Rastogi, Shubhra, Coates, Philip J., Lorimore, Sally A., Wright, Eric G.

“…Radiation-induced bystander and abscopal effects, in which DNA damage is produced in nonirradiated cells as a consequence of communication with irradiated…”
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The Influence of p53 Functions on Radiation-Induced Inflammatory Bystander-Type Signaling in Murine Bone Marrow by Lorimore, Sally A., Rastogi, Shubhra, Mukherjee, Debayan, Coates, Philip J., Wright, Eric G.

“…Radiation-induced bystander and abscopal effects, in which DNA damage is produced by inter-cellular communication, indicate mechanisms of generating damage in…”
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Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation by Lorimore, Sally A, Coates, Philip J, Wright, Eric G

“…The paradigm of genetic alterations being restricted to direct DNA damage after exposure to ionizing radiation has been challenged by observations in which…”
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Inflammatory-type responses after exposure to ionizing radiation in vivo : a mechanism for radiation-induced bystander effects? by LORIMORE, Sally A, COATES, Philip J, SCOBIE, Gillian E, MILNE, Gordon, WRIGHT, Eric G

“…Haemopoietic tissues exposed to ionizing radiation are shown to exhibit increased macrophage activation, defined by ultrastructural characteristics and…”
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Radiation-induced bone marrow apoptosis, inflammatory bystander-type signaling and tissue cytotoxicity by Mukherjee, Debayan, Coates, Philip J., Rastogi, Shubhra, Lorimore, Sally A., Wright, Eric G.

“…Abstract Purpose: A study of irradiated (0.25-2 Gy) murine bone marrow has investigated the relationships between apoptotic responses of cells exposed in vivo…”
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Responses to ionizing radiation mediated by inflammatory mechanisms by Mukherjee, Debayan, Coates, Philip J, Lorimore, Sally A, Wright, Eric G

“…Since the early years of the twentieth century, the biological consequences of exposure to ionizing radiation have been attributed solely to mutational DNA…”
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Cell and tissue responses to genotoxic stress by Coates, Philip J, Lorimore, Sally A, Wright, Eric G

“…Cancers arise as a consequence of the accumulation of multiple genetic mutations in a susceptible cell, resulting in perturbation of regulatory networks that…”
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Differential Contextual Responses of Normal Human Breast Epithelium to Ionizing Radiation in a Mouse Xenograft Model by COATES, Philip J, APPLEYARD, M. Virginia C. L, WRIGHT, Eric G, DEWAR, John A, THOMPSON, Alastair M, MURRAY, Karen, ACKLAND, Caroline, GARDNER, June, BROWN, Douglas C, ADAMSON, Dougal J. A, JORDAN, Lee B, PURDIE, Colin A, MUNRO, Alastair J

“…Radiotherapy is a key treatment option for breast cancer, yet the molecular responses of normal human breast epithelial cells to ionizing radiation are…”
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A proteomic analysis of murine bone marrow and its response to ionizing radiation by Chen, Changwei, Lorimore, Sally A., Evans, Caroline A., Whetton, Antony D., Wright, Eric G.

“…To characterize the mouse bone marrow tissue proteome and investigate the response to radiation damage we took bone marrow before and after 4‐Gy γ‐irradiation…”
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Interactions of Apoptotic Cells with Macrophages in Radiation-Induced Bystander Signaling by Rastogi, Shubhra, Boylan, Michael, Wright, Eric G., Coates, Philip J.

“…Nontargeted effects that result in ongoing cellular and tissue damage show genotype-dependency in murine models with CBA/Ca, but not C57BL/6, exhibiting…”
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Manifestations and mechanisms of non-targeted effects of ionizing radiation by Wright, Eric G

“…A well-established radiobiological paradigm is that the biological effects of ionizing radiation occur in irradiated cells as a consequence of the DNA damage…”
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Long-lived Inflammatory Signaling in Irradiated Bone Marrow Is Genome Dependent by LORIMORE, Sally A, MUKHERJEE, Debayan, ROBINSON, Joanne I, CHRYSTAL, Jennifer A, WRIGHT, Eric G

“…Ionizing radiation is carcinogenic, but genotype is a key determinant of susceptibility. Mutational DNA damage is generally attributed to cause disease, but…”
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The In Vivo Expression of Radiation-Induced Chromosomal Instability Has an Inflammatory Mechanism by Mukherjee, Debayan, Coates, Philip J., Lorimore, Sally A., Wright, Eric G.

“…Ionizing radiation is unequivocally leukemogenic and carcinogenic, and this is generally attributed to DNA damage arising as a consequence of deposition of…”
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Lack of Nontargeted Effects in Murine Bone Marrow after Low-Dose In Vivo X Irradiation by Zyuzikov, Nikolay A., Coates, Philip J., Parry, John M., Lorimore, Sally A., Wright, Eric G.

“…Exposure to high doses of ionizing radiation unequivocally produces adverse health effects including malignancy. At low doses the situation is much less clear,…”
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Radiation-Induced Delayed Bystander-Type Effects Mediated by Hemopoietic Cells by Burr, Karen L., Robinson, Joanne I., Rastogi, Shubhra, Boylan, Michael T., Coates, Philip J., Lorimore, Sally A., Wright, Eric G.

“…Genetic lesions and cell death associated with exposure to ionizing radiation have generally been attributed to DNA damage arising as a consequence of…”
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