Search Results - "Wright, Douglas"
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Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy
Published in Antioxidants & redox signaling (01-05-2023)“…Diabetic peripheral neuropathy (DPN), a complication of metabolic syndrome, type I and type II diabetes, leads to sensory changes that include slow nerve…”
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A ketogenic diet reduces mechanical allodynia and improves epidermal innervation in diabetic mice
Published in Pain (Amsterdam) (01-04-2022)“…Dietary interventions are promising approaches to treat pain associated with metabolic changes because they impact both metabolic and neural components…”
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Diabetic neuropathy
Published in Nature reviews. Disease primers (13-06-2019)“…The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of complications of these disorders. The most prevalent complication is…”
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Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain
Published in Frontiers in neuroscience (23-08-2016)“…The utilization of physical activity as a therapeutic tool is rapidly growing in the medical community and the role exercise may offer in the alleviation of…”
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A Role for Insulin in Diabetic Neuropathy
Published in Frontiers in neuroscience (23-12-2016)“…The peripheral nervous system is one of several organ systems that are profoundly affected in diabetes. The longstanding view is that insulin does not have a…”
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Foot shock stress generates persistent widespread hypersensitivity and anhedonic behavior in an anxiety-prone strain of mice
Published in Pain (Amsterdam) (01-01-2020)“…A significant subset of patients with urologic chronic pelvic pain syndrome suffer from widespread, as well as pelvic, pain and experience mood-related…”
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Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy
Published in Translational research : the journal of laboratory and clinical medicine (01-05-2012)“…Diabetic neuropathy is the most common and debilitating complication of diabetes mellitus with more than half of all patients developing altered sensation as a…”
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The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy
Published in Journal of diabetes and its complications (01-09-2012)“…Abstract Although exercise can significantly reduce the prevalence and severity of diabetic complications, no studies have evaluated the impact of exercise on…”
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Ketogenic diet prevents methylglyoxal-evoked nociception by scavenging methylglyoxal
Published in Pain (Amsterdam) (01-12-2022)“…Methylglyoxal (MGO) is a reactive dicarbonyl byproduct of glycolysis implicated in a growing number of neuropathic pain conditions, including…”
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Generalized solitary waves in the gravity‐capillary Whitham equation
Published in Studies in applied mathematics (Cambridge) (01-01-2020)“…We study the existence of traveling wave solutions to a unidirectional shallow water model, which incorporates the full linear dispersion relation for both…”
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A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice
Published in Experimental neurology (01-08-2018)“…Current experiments investigated whether a ketogenic diet impacts neuropathy associated with obesity and prediabetes. Mice challenged with a ketogenic diet…”
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Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation
Published in The Journal of neuroscience (28-09-2011)“…Musculoskeletal pain affects nearly half of all adults, most of whom are vitamin D deficient. Previous findings demonstrated that putative nociceptors…”
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Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice
Published in Pain (Amsterdam) (01-12-2013)“…Exercise reverses mechanical and visceral hyperalgesia in a prediabetic mouse model. Hyperalgesia is associated with increased nerve growth factor in the…”
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Numerical advection of moments of the particle size distribution in Eulerian models
Published in Journal of aerosol science (01-03-2007)“…‘Invalid moment sets’—sets of quantities nominally moments but for which no underlying distribution could exist and therefore not moment sets—are generated in…”
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Circulation and chemotaxis of fetal hematopoietic stem cells
Published in PLoS biology (01-03-2004)“…The major site of hematopoiesis transitions from the fetal liver to the spleen and bone marrow late in fetal development. To date, experiments have not been…”
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Ketolysis is required for the proper development and function of the somatosensory nervous system
Published in Experimental neurology (01-07-2023)“…Ketogenic diets are emerging as protective interventions in preclinical and clinical models of somatosensory nervous system disorders. Additionally,…”
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Examining Risk: A Systematic Review of Perioperative Cardiac Risk Prediction Indices
Published in Mayo Clinic proceedings (01-11-2019)“…To conduct a systematic review of published cardiac risk indices relevant to patients undergoing noncardiac surgery and to provide clinically meaningful…”
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Voluntary wheel running improves outcomes in an early life stress–induced model of urologic chronic pelvic pain syndrome in male mice
Published in Pain (Amsterdam) (01-06-2021)“…Patients with a history of early life stress (ELS) exposure have an increased risk of developing chronic pain and mood disorders later in life. The severity of…”
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Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet
Published in Experimental physiology (01-09-2018)“…New Findings What is the central question of this study? Do peripheral sensory neurons metabolize fat‐based fuel sources, and does a ketogenic diet modify…”
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