Search Results - "Wrenshall, Lucile E"

IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells by Wong, Victoria A, Dinh, Kristie N, Chen, Guangchun, Wrenshall, Lucile E

“…IL-2Rα knock out (KO) mice have been instrumental to discovering the immunoregulatory properties of IL-2Rα. While initially thought of only as a stimulatory…”
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Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue by Martinez, Hunter A., Koliesnik, Ievgen, Kaber, Gernot, Reid, Jacqueline K., Nagy, Nadine, Barlow, Graham, Falk, Ben A., Medina, Carlos O., Hargil, Aviv, Zihsler, Svenja, Vlodavsky, Israel, Li, Jin-Ping, Pérez-Cruz, Magdiel, Tang, Sai-Wen, Meyer, Everett H., Wrenshall, Lucile E., Lord, James D., Garcia, K. Christopher, Palmer, Theo D., Steinman, Lawrence, Nepom, Gerald T., Wight, Thomas N., Bollyky, Paul L., Kuipers, Hedwich F.

“…Although FOXP3 + regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are…”
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A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology by Stevens, R Brian, Foster, Kirk W, Miles, Clifford D, Kalil, Andre C, Florescu, Diana F, Sandoz, John P, Rigley, Theodore H, Malik, Tamer, Wrenshall, Lucile E

“…The two most significant impediments to renal allograft survival are rejection and the direct nephrotoxicity of the immunosuppressant drugs required to prevent…”
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Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues by Wrenshall, Lucile E, Clabaugh, Suzanne E, Cool, David R, Arumugam, Prakash, Grunwald, William C, Smith, Deandra R, Liu, Gino C, Miller, John D

“…Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For…”
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Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase by Miller, John D, Clabaugh, Suzanne E, Smith, Deandra R, Stevens, R Brian, Wrenshall, Lucile E

“…Interleukin‐2 (IL‐2) is a multifaceted cytokine with immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the…”
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Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2–CD36 functional interdependence by Ganesan, Ramya, Henkels, Karen M., Wrenshall, Lucile E., Kanaho, Yasunori, Di Paolo, Gilbert, Frohman, Michael A., Gomez‐Cambronero, Julian

“…The uptake of cholesterol carried by low‐density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the…”
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West Nile Virus—Associated Encephalitis in Recipients of Renal and Pancreas Transplants: Case Series and Literature Review by Ravindra, Kadiyala V., Freifeld, Alison G., Kalil, Andre C., Mercer, David F., Grant, Wendy J., Botha, Jean F., Wrenshall, Lucile E., Stevens, R. Brian

“…Although West Nile fever is mild in the vast majority of infected persons, there is growing evidence that the disease may be more severe in the…”
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Expression of a Functional IL-2 Receptor in Vascular Smooth Muscle Cells by Arumugam, Prakash, Carroll, Katie L, Berceli, Scott A, Barnhill, Spencer, Wrenshall, Lucile E

“…Many nonlymphoid cell types express at least two, if not all three, subunits of the IL-2R; although, compared with lymphocytes, relatively little is known…”
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Phenotypic and Functional Maturation of Dendritic Cells Mediated by Heparan Sulfate by Kodaira, Yuzo, Nair, Smita K, Wrenshall, Lucile E, Gilboa, Eli, Platt, Jeffrey L

“…Primary immune responses are thought to be induced by dendritic cells. To promote such responses, dendritic cells must be activated by exogenous agonists, such…”
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Regional manifestations and control of the immune system by Saadi, Soheyla, Wrenshall, Lucile E., Platt, Jeffrey L.

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Sitagliptin therapy in kidney transplant recipients with new-onset diabetes after transplantation by Lane, James T, Odegaard, David E, Haire, Claire E, Collier, Dean S, Wrenshall, Lucile E, Stevens, R Brian

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Heparan Sulfate Proteoglycan Metabolism and the Fate of Grafted Tissues by Platt, Jeffrey L, Wrenshall, Lucile E, Johnson, Geoffrey B, Cascalho, Marilia

“…Tissue and organ transplants between genetically distinct individuals are always or nearly always rejected. The universality and speed of transplant rejection…”
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Modulation of macrophage and B cell function by glycosaminoglycans by Wrenshall, Lucile E., Stevens, R. Brian, Cerra, Frank B., Platt, Jeffrey L.

“…There is increasing evidence that the behavior of antigen‐presenting cells may be regulated, in part, by the surrounding microenvironment. Components of the…”
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A Randomized 2×2 Factorial Trial, Part 1: Single-Dose Rabbit Antithymocyte Globulin Induction May Improve Renal Transplantation Outcomes by Stevens, R Brian, Foster, Kirk W, Miles, Clifford D, Lane, James T, Kalil, Andre C, Florescu, Diana F, Sandoz, John P, Rigley, Theodore H, Nielsen, Kathleen J, Skorupa, Jill Y, Kellogg, Anna M, Malik, Tamer, Wrenshall, Lucile E

“…BACKGROUNDWe conducted a randomized and unblinded 2×2 sequential-factorial trial, composed of an induction arm (part 1) comparing single-dose (SD) versus…”
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A Randomized 2x2 Factorial Trial, Part 1: Single-Dose Rabbit Antithymocyte Globulin Induction May Improve Renal Transplantation Outcomes by Stevens, R Brian, Foster, Kirk W, Miles, Clifford D, Lane, James T, Kalil, Andre C, Florescu, Diana F, Sandoz, John P, Rigley, Theodore H, Nielsen, Kathleen J, Skorupa, Jill Y, Kellogg, Anna M, Malik, Tamer, Wrenshall, Lucile E

“…We conducted a randomized and unblinded 2 x 2 sequential-factorial trial, composed of an induction arm comparing single-dose (SD) versus divided-dose rabbit…”
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Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use by SMITH, Kelly D, WRENSHALL, Lucile E, NICOSIA, Roberto F, PICHLER, Raimund, MARSH, Christopher L, ALPERS, Charles E, POLISSAR, Nayak, DAVIS, Connie L

“…Delayed graft function (DGF) occurs in 15 to 25% (range, 10 to 62%) of cadaveric kidney transplant recipients and up to 9% of living donor recipients. In…”
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Regional manifestations and control of the immune system by Saadi, Soheyla, Wrenshall, Lucile E., Platt, Jeffrey L.

“…ABSTRACT Although immune responses are generally considered to be systemic, local events such as interaction of complement products with blood vessels and with…”
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Randomized Trial of Single-Dose Versus Divided-Dose Rabbit Anti-Thymocyte Globulin Induction in Renal Transplantation : An Interim Report by STEVENS, R. Brian, MERCER, David F, SKORUPA, Anna J, CHRISTENSEN, Kecia A, SANDOZ, John P, KELLOGG, Anna M, LANGNAS, Alan N, WRENSHALL, Lucile E, GRANT, Wendy J, FREIFELD, Alison G, LANE, James T, GROGGEL, Gerald C, RIGIEY, Theodore H, NIELSEN, Kathleen J, HENNING, Megan E, SKORUPA, Jill Y

“…The optimal dosing protocol for rabbit anti-thymocyte globulin (rATG) induction in renal transplantation has not been determined, but evidence exists that rATG…”
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Single-dose rATG induction at renal transplantation: superior renal function and glucoregulation with less hypomagnesemia by Stevens, R. Brian, Lane, James T., Boerner, Brian P., Miles, Clifford D., Rigley, Theodore H., Sandoz, John P., Nielsen, Kathleen J., Skorupa, Jill Y., Skorupa, Anna J., Kaplan, Bruce, Wrenshall, Lucile E.

“…Stevens RB, Lane JT, Boerner BP, Miles CD, Rigley TH, Sandoz JP, Nielsen KJ, Skorupa JY, Skorupa AJ, Kaplan B, Wrenshall LE. Single‐dose rATG induction at…”
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Regulation of T Cell Homeostasis by Heparan Sulfate-Bound IL-2 by Wrenshall, Lucile E, Platt, Jeffrey L

“…Although IL-2 is commonly thought to promote proliferation of T lymphocytes, mice deficient in IL-2 exhibit splenomegaly, lymphocytosis, and autoimmunity,…”
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