Search Results - "Wrennall, Joe A"

Understanding how cystic fibrosis mutations disrupt CFTR function: From single molecules to animal models by Wang, Yiting, Wrennall, Joe A., Cai, Zhiwei, Li, Hongyu, Sheppard, David N.

“…Defective epithelial ion transport is the hallmark of the life-limiting genetic disease cystic fibrosis (CF). This abnormality is caused by mutations in the…”
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Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression by Wu, Tongde, Wrennall, Joe A, Dang, Hong, Baines, Deborah L, Tarran, Robert

“…Primary human bronchial epithelial cultures (HBECs) are used to study airway physiology, disease, and drug development. HBECs often replicate human airway…”
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SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel by Wu, Tongde, Goriounova, Alexandra S., Worthington, Erin N., Wrennall, Joe A., Ghosh, Arunava, Ahmad, Saira, Flori Sassano, M., Tarran, Robert

“…Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that…”
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ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry by Goriounova, Alexandra S., Flori Sassano, M., Wrennall, Joe A., Tarran, Robert

“…•We recently developed ELD607, an 11 amino acid peptidomimetic that inhibits store operated Ca2+ entry (SOCE).•Here, we studied ELD607’s mechanism of action:…”
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Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs by Goriounova, Alexandra S., Gilmore, Rodney C., Wrennall, Joe A., Tarran, Robert

“…•In the lung, Orai1 expression is highest in immune cells.•Orai1/STIM1 colocalization is increased in asthma and CF lung epithelial, interstitial, and luminal…”
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A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model by Wrennall, Joe A, Ahmad, Saira, Worthington, Erin N, Wu, Tongde, Goriounova, Alexandra S, Voeller, Alexis S, Stewart, Ian E, Ghosh, Arunava, Krajewski, Krzysztof, Tilley, Steven L, Hickey, Anthony J, Sassano, M Flori, Tarran, Robert

“…Orai1 is a plasma membrane Ca  channel that mediates store-operated Ca  entry (SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1…”
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Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model by Ahmad, Saira, Wrennall, Joe A., Goriounova, Alexandra S., Sekhri, Malika, Iskarpatyoti, Jason A., Ghosh, Arunava, Abdelwahab, Sabri H., Voeller, Alexis, Rai, Mani, Mahida, Rahul Y., Krajewski, Krzysztof, Ignar, Diane M., Greenbaum, Alon, Moran, Timothy P., Tilley, Stephen L., Thickett, David R., Sassano, M. Flori, Tarran, Robert

“…ELD607 is a novel Orai1 antagonist that shows promise in treating acute respiratory distress syndrome (ARDS) caused by bacterial pneumonia. ARDS has a high…”
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Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding by Ghosh, Arunava, Girish, Vishruth, Yuan, Monet Lou, Coakley, Raymond D, Wrennall, Joe A, Alexis, Neil E, Sausville, Erin L, Vasudevan, Anand, Chait, Alexander R, Sheltzer, Jason M, Tarran, Robert

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3. Ethanol alters e-liquid physicochemical properties, toxicity, and nicotine deposition by Biggart, Matthew G.S., Wrennall, Joe A., Strenta, Michael, Rouillard, Kaitlyn R., Hill, David B., Tarran, Robert

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Two Small Molecules Restore Stability to a Subpopulation of the Cystic Fibrosis Transmembrane Conductance Regulator with the Predominant Disease-causing Mutation by Meng, Xin, Wang, Yiting, Wang, Xiaomeng, Wrennall, Joe A., Rimington, Tracy L., Li, Hongyu, Cai, Zhiwei, Ford, Robert C., Sheppard, David N.

“…Cystic fibrosis (CF) is caused by mutations that disrupt the plasma membrane expression, stability, and function of the cystic fibrosis transmembrane…”
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Chronic E-Cigarette Exposure Alters Human Alveolar Macrophage Morphology and Gene Expression by Davis, Eric S, Ghosh, Arunava, Coakley, Raymond D, Wrennall, Joe A, Lubamba, Bob A, Rowell, Temperance R, Dang, Hong, Pawlak, Erica A, Li, Quefeng, Alexis, Neil E, Ribeiro, Carla M P, Tarran, Robert

“…Abstract Introduction Alveolar macrophages (AMs) are lung-resident immune cells that phagocytose inhaled particles and pathogens, and help coordinate the…”
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SPLUNC1 is a negative regulator of the Orai1 Ca 2+ channel by Wu, Tongde, Goriounova, Alexandra S, Worthington, Erin N, Wrennall, Joe A, Ghosh, Arunava, Ahmad, Saira, Flori Sassano, M, Tarran, Robert

“…Orai1 is a ubiquitously-expressed plasma membrane Ca channel that is involved in store-operated Ca entry (SOCE): a fundamental biological process that…”
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Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an ARDS Model by Ahmad, Saira, Wrennall, Joe A, Goriounova, Alexandra S, Sekhri, Malika, Iskarpatyoti, Jason A, Ghosh, Arunava, Abdelwahab, Sabri H, Voeller, Alexis, Rai, Mani, Mahida, Rahul Y, Krajewski, Krzysztof, Ignar, Diane M, Greenbaum, Alon, Moran, Timothy P, Tilley, Stephen L, Thickett, David R, Sassano, M Flori, Tarran, Robert

“…Acute Respiratory Distress Syndrome (ARDS) has an unacceptably high mortality rate (35%) and is without effective therapy. Orai1 is a Ca channel involved in…”
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