Search Results - "Wray, Susan"

Congratulations to Physiological Reports by Wray, Susan

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The Physiological Mechanisms of the Sex-Based Difference in Outcomes of COVID19 Infection by Wray, Susan, Arrowsmith, Sarah

“…The scale of the SARS-CoV-2 pandemic has thrust a spotlight on the sex-based differences in response to viral diseases; morbidity and mortality are greater in…”
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Insights into the uterus by Wray, Susan

“…A better understanding of the mechanisms that generate and modulate uterine contractility is needed if progress is to be made in the prevention or treatment of…”
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Editorial overview: Current research in physiology by Wray, Susan

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Progesterone Directly and Rapidly Inhibits GnRH Neuronal Activity via Progesterone Receptor Membrane Component 1 by Bashour, Nicholas Michael, Wray, Susan

“…GnRH neurons are essential for reproduction, being an integral component of the hypothalamic-pituitary-gonadal axis. Progesterone (P4), a steroid hormone,…”
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Hypoxia-induced force increase (HIFI) is a novel mechanism underlying the strengthening of labor contractions, produced by hypoxic stresses by Alotaibi, Mohammed, Arrowsmith, Sarah, Wray, Susan

“…For successful birth, contractions need to become progressively stronger. The underlying mechanisms are unknown, however. We have found that a novel mechanism,…”
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Sarcoplasmic Reticulum Function in Smooth Muscle by Wray, Susan, Burdyga, Theodor

“…Department of Physiology, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom The sarcoplasmic reticulum (SR) of smooth muscles…”
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Inhibitory effect of visfatin and leptin on human and rat myometrial contractility by Mumtaz, Sadaf, AlSaif, Seham, Wray, Susan, Noble, Karen

“…The purpose of this study was to investigate the effect of visfatin on in vitro myometrial contractility in human and rat, and compare it to leptin. Myometrial…”
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A new slow releasing, H₂S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometrium by Robinson, Hayley, Wray, Susan

“…Better tocolytics are required to help prevent preterm labour. The gaseotransmitter Hydrogen sulphide (H(2)S) has been shown to reduce myometrial contractility…”
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Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle by Wray, Susan, Prendergast, Clodagh, Arrowsmith, Sarah

“…In smooth muscle tissues, calcium-activated chloride channels (CaCC) provide the major anionic channel. Opening of these channels leads to chloride efflux and…”
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Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells by Forni, Paolo Emanuele, Taylor-Burds, Carol, Melvin, Vida Senkus, Williams, Trevor, Williams, Taylor, Wray, Susan

“…The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial. Genetic Cre-lox lineage tracing of the neural crest (NC) versus ectodermal…”
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Neural Crest and Olfactory System: New Prospective by Forni, Paolo E., Wray, Susan

“…Sensory neurons in vertebrates are derived from two embryonic transient cell sources: neural crest (NC) and ectodermal placodes. The placodes are thickenings…”
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Neuropeptide Y Directly Inhibits Neuronal Activity in a Subpopulation of Gonadotropin-Releasing Hormone-1 Neurons via Y1 Receptors by Klenke, Ulrike, Constantin, Stephanie, Wray, Susan

“…Neuropeptide Y (NPY), a member of the pancreatic polypeptide family, is an orexigenic hormone. GnRH-1 neurons express NPY receptors. This suggests a direct…”
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Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial by Chiswick, Carolyn, MBChB, Reynolds, Rebecca M, Prof, Denison, Fiona, MD, Drake, Amanda J, PhD, Forbes, Shareen, PhD, Newby, David E, Prof, Walker, Brian R, Prof, Quenby, Siobhan, Prof, Wray, Susan, Prof, Weeks, Andrew, Prof, Lashen, Hany, MD, Rodriguez, Aryelly, MSc, Murray, Gordon, Prof, Whyte, Sonia, MSc, Norman, Jane E, Prof

“…Summary Background Maternal obesity is associated with increased birthweight, and obesity and premature mortality in adult offspring. The mechanism by which…”
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Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current by Constantin, Stephanie, Quignon, Clarisse, Pizano, Katherine, Shostak, David M, Wray, Susan

“…Vasoactive intestinal peptide (VIP) is an important component of the suprachiasmatic nucleus (SCN) which relays circadian information to neuronal populations,…”
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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design by Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Crai, David J., Freissmutha, Michael, Grubera, Christian W.

“…Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were…”
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Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum by Shostak, David M, Constantin, Stephanie, Flannery, Jill, Wray, Susan

“…In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is…”
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Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation by Taylor-Burds, Carol, Cheng, Paul, Wray, Susan

“…A developmental "switch" in chloride transporters occurs in most neurons resulting in GABAA mediated hyperpolarization in the adult. However, several neuronal…”
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Nasal Placode Development, GnRH Neuronal Migration and Kallmann Syndrome by Cho, Hyun-Ju, Shan, Yufei, Whittington, Niteace C, Wray, Susan

“…The development of Gonadotropin releasing hormone-1 (GnRH) neurons is important for a functional reproduction system in vertebrates. Disruption of GnRH results…”
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The combination tocolytic effect of magnesium sulfate and an oxytocin receptor antagonist in myometrium from singleton and twin pregnancies by Arrowsmith, Sarah, PhD, Neilson, James, MD, Wray, Susan, PhD

“…Background Preterm birth at <37 weeks of gestation is the most common and costly complication of pregnancy and remains the leading cause of neonatal morbidity,…”
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