Search Results - "Wozniak, J A"

Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma by Krug, L.M, Wozniak, A.J, Kindler, H.L, Feld, R, Koczywas, M, Morero, J.L, Rodriguez, C.P, Ross, H.J, Bauman, J.E, Orlov, S.V, Ruckdeschel, J.C, Mita, A.C, Fein, L, He, X, Hall, R, Kawabe, T, Sharma, S

“…Highlights • CBP501 enhances cisplatin cytotoxicity and blocks DNA repair at the G2 checkpoint. • Patients with pleural mesothelioma received…”
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Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: a Southwest Oncology Group study by Wozniak, A J, Crowley, J J, Balcerzak, S P, Weiss, G R, Spiridonidis, C H, Baker, L H, Albain, K S, Kelly, K, Taylor, S A, Gandara, D R, Livingston, R B

“…Cisplatin has played a major role in the treatment of non-small-cell lung cancer (NSCLC). This randomized trial was performed by the Southwest Oncology Group…”
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Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Vinorelbine Plus Cisplatin in the Treatment of Patients With Advanced Non–Small-Cell Lung Cancer: A Southwest Oncology Group Trial by KELLY, Karen, CROWLEY, John, ISRAEL, Valerie K, LIVINGSTON, Robert B, GANDARA, David R, BUNN, Paul A, PRESANT, Cary A, GREVSTAD, Patra K, MOINPOUR, Carol M, RAMSEY, Scott D, WOZNIAK, Antoinette J, WEISS, Geoffrey R, MOORE, Dennis F

“…This randomized trial was designed to determine whether paclitaxel plus carboplatin (PC) offered a survival advantage over vinorelbine plus cisplatin (VC) for…”
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A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene by Eriksson, A. E, Baase, W. A, Wozniak, J. A, Matthews, B. W

“…The hydrophobic cores of proteins are generally well packed, with few cavities. Mutations in which a bulky buried residue such as leucine or phenylalanine is…”
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Single-agent vinorelbine in the treatment of non-small cell lung cancer by Wozniak, A J

“…Vinorelbine, a vinca alkaloid, was the first drug in over 20 years to be approved by the Food and Drug Administration for treatment of advanced non-small cell…”
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A single-arm, multicenter, phase II trial of osimertinib in patients with epidermal growth factor receptor exon 18 G719X, exon 20 S768I, or exon 21 L861Q mutations by Villaruz, L.C., Wang, X., Bertino, E.M., Gu, L., Antonia, S.J., Burns, T.F., Clarke, J., Crawford, J., Evans, T.L., Friedland, D.M., Otterson, G.A., Ready, N.E., Wozniak, A.J., Stinchcombe, T.E.

“…For patients with stage IV non-small-cell lung cancer with epidermal growth factor receptor (EGFR) exon 19 deletions and exon 21 L858R mutations, osimertinib…”
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Lung cancer in patients < 50 years of age: the experience of an academic multidisciplinary program by Gadgeel, S M, Ramalingam, S, Cummings, G, Kraut, M J, Wozniak, A J, Gaspar, L E, Kalemkerian, G P

“…To determine if the clinicopathologic features and survival of lung cancer patients < 50 years of age differ from those of older patients. Retrospective review…”
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Clinical Outcomes in Elderly Patients with Advanced Non-small Cell Lung Cancer: Results from ARIES, a Bevacizumab Observational Cohort Study by Wozniak, A.J, Kosty, M.P, Jahanzeb, M, Brahmer, J.R, Spigel, D.R, Leon, L, Fish, S, Flick, E.D, Hazard, S.J, Lynch, T.J

“…Abstract Aims Retrospective analyses from first-line clinical studies in advanced non-small cell lung cancer (NSCLC) have reported conflicting results on…”
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Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme by Daopin, S, Alber, T, Baase, W A, Wozniak, J A, Matthews, B W

“…Packing interactions in bacteriophage T4 lysozyme were explored by determining the structural and thermodynamic effects of substitutions for Ala98 and…”
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2000 Update of Recommendations for the Use of Hematopoietic Colony-Stimulating Factors: Evidence-Based, Clinical Practice Guidelines by Ozer, Howard, Armitage, James O., Bennett, Charles L., Crawford, Jeffrey, Demetri, George D., Pizzo, Philip A., Schiffer, Charles A., Smith, Thomas J., Somlo, George, Wade, James C., Wade, James L., Winn, Rodger J., Wozniak, Antoinette J., Somerfield, Mark R.

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Anticoagulation therapy for radiation-induced myelopathy by Liu, CY, Yim, BT, Wozniak, AJ

“…OBJECTIVE: To report the use of heparin and enoxaparin for radiation-induced myelopathy. CASE SUMMARY: A 46-year-old white woman with presumed metastatic lung…”
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Structural Studies of Mutants of T4 Lysozyme That Alter Hydrophobic Stabilization by Matsumura, M, Wozniak, J A, Dao-pin, S, Matthews, B W

“…Multiple replacements at amino acid position 3 of bacteriophage T4 lysozyme have shown that the conformational stability of the protein is directly governed by…”
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Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme by Alber, Tom, Dao-pin, Sun, Wilson, Keith, Wozniak, Joan A, Cook, Sean P, Matthews, Brian W

“…Measurements of changes in structure and stability caused by 13 different substitutions for threonine 157 in phage T4 lysozyme show that the most stable…”
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Structure of a thermostable disulfide-bridge mutant of phage T4 lysozyme shows that an engineered cross-link in a flexible region does not increase the rigidity of the folded protein by Pjura, P. E, Matsumura, M, Wozniak, J. A, Matthews, Brian W

“…A disulfide bond introduced between amino acid positions 9 and 164 in phage T4 lysozyme has been shown to significantly increase the stability of the enzyme…”
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Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability by Dao-pin, S, Söderlind, E, Baase, W A, Wozniak, J A, Sauer, U, Matthews, B W

“…Bacteriophage T4 lysozyme is a basic molecule with an isoelectric point above 9.0, and an excess of nine positive charges at neutral pH. It might be expected…”
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Neurotoxicity of antineoplastic agents by Hussain, M, Wozniak, A J, Edelstein, M B

“…to review the neurotoxicity associated with antineoplastic agents. four hundred articles, abstracts and book chapters were selected for review. One hundred and…”
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Posterior cricoarytenoid and diaphragm activities during tidal breathing in neonates by Kosch, P C, Hutchinson, A A, Wozniak, J A, Carlo, W A, Stark, A R

“…To investigate airflow regulation in newborn infants, we recorded airflow, volume, diaphragm (Di), and laryngeal electromyogram (EMG) during spontaneous…”
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A Genetic Screen for Mutations That Increase the Thermal Stability of Phage T4 Lysozyme by Alber, Tom, Wozniak, Joan A.

“…A method has been developed to screen for mutants of phage T4 lysozyme that are more stable than the wild-type enzyme. Using an assay that detects lysozyme…”
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Replacements of Pro86 in phage T4 lysozyme extend an α-helix but do not alter protein stability by ALBER, T, BELL, J. A, SUN DAO-PIN, NICHOLSON, H, WOZNIAK, J. A, COOK, S, MATTHEWS, B. W

“…To investigate the relation between protein stability and the predicted stabilities of individual secondary structural elements, residue Pro86 in an…”
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Endotracheal measurement of thyroarytenoid activity in newborn lambs by Hutchison, A A, Wozniak, J A

“…Laryngeal control of expiratory airflow is a principal means by which the newborn establishes and maintains absolute lung volume. Specifically, retardation of…”
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