Search Results - "Wotring, Virginia E."

Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts by Kast, Johannes, Yu, Yichao, Seubert, Christoph N., Wotring, Virginia E., Derendorf, Hartmut

“…Space agencies are working intensely to push the current boundaries of human spaceflight by sending astronauts deeper into space than ever before, including…”
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Supplying a Pharmacy for NASA Exploration Spaceflight: Challenges and Current Understanding by Blue, Rebecca S, Bayuse, Tina M, Daniels, Vernie R, Wotring, Virginia E, Suresh, Rahul, Mulcahy, Robert A, Antonsen, Erik L

“…In order to maintain crew health and performance during long-duration spaceflight outside of low-Earth orbit, NASA and its international partners must be…”
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Medication use by U.S. crewmembers on the International Space Station by Wotring, Virginia E.

“…ABSTRACT The environment on the International Space Station (ISS) includes a variety of potential physiologic stressors, including low gravity, elevated…”
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Chemical Potency and Degradation Products of Medications Stored Over 550 Earth Days at the International Space Station by Wotring, Virginia E.

“…Medications degrade over time, and degradation is hastened by extreme storage conditions. Current procedures ensure that medications aboard the International…”
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Role of acetylcholine in nitric oxide production in the salamander retina by Cimini, Beth A., Strang, Christianne E., Wotring, Virginia E., Keyser, Kent T., Eldred, William D.

“…Although acetylcholine is one of the most widely studied neurotransmitters in the retina, many questions remain about its downstream signaling mechanisms. In…”
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Potential Venous Thromboembolism Risk in Female Astronauts by Jain, Varsha, Ploutz-Snyder, Robert, Young, Millennia, Charvat, Jacqueline M, Wotring, Virginia E

“…Whether the unique environment of space affects astronaut risk of venous thromboembolism (VTE) is not known. On Earth, it is known that use of combined oral…”
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Medically induced amenorrhea in female astronauts by Jain, Varsha, Wotring, Virginia E

“…Medically induced amenorrhea can be achieved through alterations in the normal regulatory hormones via the adoption of a therapeutic agent, which prevents…”
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Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight by Blue, Rebecca S., Chancellor, Jeffery C., Antonsen, Erik L., Bayuse, Tina M., Daniels, Vernie R., Wotring, Virginia E.

“…As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of…”
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Biomedical findings from NASA’s Project Mercury: a case series by Carpentier, William R., Charles, John B., Shelhamer, Mark, Hackler, Amanda S., Johnson, Tracy L., Domingo, Catherine M. M., Sutton, Jeffrey P., Scott, Graham B. I., Wotring, Virginia E.

“…The United States first sent humans into space during six flights of Project Mercury from May 1961 to May 1963. These flights were brief, with durations…”
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Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity by Wotring, Virginia E, Weiss, David S

“…Selective permeability is a fundamental property of ion channels. The Cys-loop receptor superfamily is composed of both excitatory (ACh, 5-HT) and inhibitory…”
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Permeability and single channel conductance of human homomeric ρ1 GABAC receptors by Wotring, Virginia E., Chang, Yongchang, Weiss, David S.

“…1 Homomeric human ρ1 GABAC receptors were expressed in Xenopus oocytes and in human embryonic kidney cells (HEK293) in order to examine their conductance and…”
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Picrotoxin-mediated antagonism of α3β4 and α7 acetylcholine receptors by Erkkila, Brian E, Weiss, David S, Wotring, Virginia E

“…Picrotoxin (PTX) is a convulsant that antagonizes many inhibitory ligand-gated receptors. The mechanism of PTX block is believed to involve residues which line…”
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Effects of Radiation Exposure and Dietary Iron on Liver Metabolic Gene Expression by Wotring, Virginia E

“…Abstract only Increased exposure to gamma radiation and subsequent oxidative effects are among the physiological stressors associated with spaceflight. High…”
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Changes in liver metabolic gene expression after radiation exposure by Wotring, Virginia E, Peters, Calvin P

“…Abstract only Increased exposure to radiation is one physiological stressor associated with spaceflight. While known to alter normal physiological function,…”
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Evidence that the TM1-TM2 Loop Contributes to the ρ1 GABA Receptor Pore by Filippova, Natalia, Wotring, Virginia E., Weiss, David S.

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Picrotoxin-mediated antagonism of alpha3beta4 and alpha7 acetylcholine receptors by Erkkila, Brian E, Weiss, David S, Wotring, Virginia E

“…Picrotoxin (PTX) is a convulsant that antagonizes many inhibitory ligand-gated receptors. The mechanism of PTX block is believed to involve residues which line…”
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Evidence that the TM1-TM2 loop contributes to the rho1 GABA receptor pore by Filippova, Natalia, Wotring, Virginia E, Weiss, David S

“…Considerable evidence indicates the second transmembrane domain (TM2) of the gamma-aminobutyric acid (GABA) receptor lines the integral ion pore. To further…”
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Evidence that the TM1-TM2 Loop Contributes to the ρ1 GABA Receptor Pore by Natalia Filippova, Virginia E. Wotring, David S. Weiss

“…Considerable evidence indicates the second transmembrane domain (TM2) of the γ-aminobutyric acid (GABA) receptor lines the integral ion pore. To further…”
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Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight by Blue, Rebecca S, Chancellor, Jeffery C, Antonsen, Erik L, Bayuse, Tina M, Daniels, Vernie R, Wotring, Virginia E

“…Nature Microgravity 5:15 (2019) As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges…”
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Permeability and single channel conductance of human homomeric ρ1 GABAC receptors by Virginia E Wotring, Yongchang Chang, David S Weiss

“…Homomeric human ρ1 GABA C receptors were expressed in Xenopus oocytes and in human embryonic kidney cells (HEK293) in order to examine their conductance and…”
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