Search Results - "Worthington, Judith"

Predicting flow cytometry crossmatch results from single‐antigen bead testing by Flynn, Patrick A., Fernando, Sebastian, Worthington, Judith E., Poulton, Kay V.

“…The aim of this study was to devise an algorithm that would predict flow cytometry crossmatch (FCXM) results using single‐antigen bead (SAB) mean fluorescent…”
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Associations between human leukocyte antigens and renal function by Lowe, Marcus, Payton, Antony, Verma, Arpana, Worthington, Judith, Gemmell, Isla, Hamilton, Patrick, Ollier, William, Augustine, Titus, Poulton, Kay

“…Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings with little consensus on the exact…”
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Evaluating the Clinical Relevance of Antibodies against Non-Human Leukocyte Antigen in Kidney Transplantation by Bhutani, Shiv, Harris, Shelley, Carr, Michelle, Russell-Lowe, Marcus, Worthington, Judith, Wu, Henry H L, Chinnadurai, Rajkumar, Poulton, Kay

“…: Kidney transplantation is the preferred modality of kidney replacement therapy for eligible patients with end-stage kidney disease (ESKD), given that it has…”
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Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome by WORTHINGTON, Judith E, MARTIN, Susan, AL-HUSSEINI, Dalia M, DYER, Philip A, JOHNSON, Robert W. G

“…This study aimed to determine whether the production, in renal transplant recipients, of antibodies directed against donor HLA mismatches is predictive of…”
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Preventing kidney transplant failure by screening for antibodies against human leucocyte antigens followed by optimised immunosuppression: OuTSMART RCT by Stringer, Dominic, Gardner, Leanne, Shaw, Olivia, Clarke, Brendan, Briggs, David, Worthington, Judith, Buckland, Matthew, Hilton, Rachel, Picton, Michael, Thuraisingham, Raj, Borrows, Richard, Baker, Richard, Tinch-Taylor, Rose, Horne, Robert, McCrone, Paul, Kelly, Joanna, Murphy, Caroline, Peacock, Janet, Dorling, Anthony

“…Design Investigator-led, prospective, open-labelled marker-based strategy (hybrid) randomised trial. Background Allografts in 3% of kidney transplant patients…”
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Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome by WORTHINGTON, Judith E, MCEWEN, Anna, MCWILLIAM, Lorna J, PICTON, Michael L, MARTIN, Susan

“…We carried out a retrospective study of C4d staining in paraffin sections from renal transplant biopsies to determine the association between C4d staining,…”
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Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies by Stringer, Dominic, Gardner, Leanne M, Peacock, Janet L, Rebollo-Mesa, Irene, Hilton, Rachel, Shaw, Olivia, Baker, Richard, Clark, Brendan, Thuraisingham, Raj C, Buckland, Matthew, Picton, Michael, Worthington, Judith, Borrows, Richard, Briggs, David, Shah, Sapna, Shiu, Kin Yee, McCullough, Keith, Phanish, Mysore, Hegarty, Janet, Stoves, John, Ahmed, Aimun, Ayub, Waqar, Horne, Robert, McCrone, Paul, Kelly, Joanna, Murphy, Caroline, Dorling, Anthony

“…Chronic rejection is the single biggest cause of premature kidney graft failure. HLA antibodies (Ab) are an established prognostic biomarker for premature…”
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The detection and definition of IgM alloantibodies in the presence of IgM autoantibodies using flowPRA beads by Khan, Naheed, Robson, Amanda J, Worthington, Judith E, Martin, Susan

“…We have developed a flow cytometry–based screening method using FlowPRA (One Lambda) human leukocyte antigen (HLA) class I panel beads and FlowPRA (One…”
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Human leukocyte antigen epitope mismatch loads and the development of de novo donor‐specific antibodies in cardiothoracic organ transplantation by Bedford, Amy, Jervis, Steven, Worthington, Judith, Lowe, Marcus, Poulton, Kay

“…De novo donor‐specific human leucocyte antigen (HLA) antibodies (dnDSA) are associated with increased risk of rejection and mortality in solid organ…”
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Application of HLA molecular level mismatching in ethnically diverse kidney transplant recipients receiving a steroid-sparing immunosuppression protocol by Santos, Eva, Spensley, Katrina, Gunby, Nicola, Worthington, Judith, Roufosse, Candice, Anand, Arthi, Willicombe, Michelle

“…Defining HLA mismatch at the molecular compared with the antigen level has been shown to be superior in predicting alloimmune responses, although data from…”
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Emotional labour in oncology and haematology nursing: exploring effects and coping strategies by Ryan, Alice, Cross, Debbie, Worthington, Judith

“…Why you should read this article:• To find out how oncology and haematology nurses describe the emotional demands of their role• To read about formal and…”
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The role of HLA-specific antibodies in kidney transplant rejection: published studies and local data by Worthington, Judith E, Martin, Susan, Barker, Anna J, McWilliam, Lorna J, Dyer, Philip A

“…The post-transplantation production of antibodies directed against donor HLA class I and class II mismatches has been shown to be associated with transplant…”
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Systematic review of associations between HLA and renal function by Lowe, Marcus, Jervis, Steven, Payton, Antony, Poulton, Kay, Worthington, Judith, Gemmell, Isla, Verma, Arpana

“…Introduction Kidney dysfunction is a highly significant disease, both in the United Kingdom and globally. Many previous studies have reported associations…”
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Human leukocyte antigen associations with renal function among ethnic minorities in the United Kingdom by Lowe, Marcus, Payton, Antony, Verma, Arpana, Gemmell, Isla, Worthington, Judith, Hamilton, Patrick, Ollier, William, Augustine, Titus, Poulton, Kay

“…Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings. There has been a lack of research…”
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An early evaluation of the HISTO SPOT® AB ID Class I & II test in cardiothoracic transplant patients by Cashin, James, Flynn, Patrick, Worthington, Judith, Lowe, Marcus, Canterbury, Andrew, Launhardt, Kristin, Crosby, Ian, Sheldon, Stephen, Venkateswaran, Rajamiyer, Poulton, Kay

“…The HISTO SPOT®AB ID assay (BAG Diagnostics GmbH) is a novel single antigen HLA Class I & II antibody definition test used with the MR.SPOT® processor. We…”
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BSHI and BTS UK guideline on the detection of alloantibodies in solid organ (and islet) transplantation by Battle, Richard, Pritchard, Deborah, Peacock, Sarah, Hastie, Catherine, Worthington, Judith, Jordan, Sue, McCaughlan, Jennifer A, Barnardo, Martin, Cope, Rebecca, Collins, Claire, Diaz‐Burlinson, Natalia, Rosser, Carla, Foster, Luke, Kallon, Delordson, Shaw, Olivia, Briggs, David, Turner, David, Anand, Arthi, Akbarzad‐Yousefi, Arash, Sage, Deborah

“…Solid organ transplantation represents the best (and in many cases only) treatment option for patients with end‐stage organ failure. The effectiveness and…”
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Mortality in diabetes: pancreas transplantation is associated with significant survival benefit by van Dellen, David, Worthington, Judith, Mitu-Pretorian, Otilia M, Ghazanfar, Abbas, Forgacs, Bence, Pararajasingam, Ravi, Campbell, Babatunde, Parrott, Neil R, Augustine, Titus, Tavakoli, Afshin

“…Pancreas transplantation in complicated type 1 (insulin dependent) diabetes mellitus improves the quality of life, increases longevity and stabilizes diabetic…”
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Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trial by Stringer, Dominic, Gardner, Leanne, Shaw, Olivia, Clarke, Brendan, Briggs, David, Worthington, Judith, Buckland, Matthew, Danzi, Guilherme, Hilton, Rachel, Picton, Michael, Thuraisingham, Raj, Borrows, Richard, Baker, Richard, McCullough, Keith, Stoves, John, Phanish, Mysore, Shah, Sapna, Shiu, Kin Yee, Walsh, Stephen B., Ahmed, Aimun, Ayub, Waqar, Hegarty, Janet, Tinch-Taylor, Rose, Georgiou, Evangelos, Bidad, Natalie, Kılıç, Ayşenur, Moon, Zoe, Horne, Robert, McCrone, Paul, Kelly, Joanna, Murphy, Caroline, Peacock, Janet, Dorling, Anthony

“…3% of kidney transplant recipients return to dialysis annually upon allograft failure. Development of antibodies (Ab) against human leukocyte antigens (HLA) is…”
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Pancreas Transplantation Offers Definite Survival Benefit when Compared with Live Donor Kidney Transplantation in Diabetic Patients by Moinuddin, Zia, Worthington, Judith, Khambalia, Hussein, gacs, Bence, Augustine, Titus, Tavakoli, Afshin, van Dellen, David

“…Pancreas transplantation for patients with end-stage renal failure (ESRF) due to type 1 diabetes mellitus improves quality of life and stabilises diabetic…”
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Monthly variance in UK renal transplantation activity: a national retrospective cohort study by Lowe, Marcus, Maidstone, Robert, Poulton, Kay, Worthington, Judith, Durrington, Hannah J, Ray, David W, van Dellen, David, Asderakis, Argiris, Blaikley, John, Augustine, Titus

“…ObjectiveTo identify whether renal transplant activity varies in a reproducible manner across the year.DesignRetrospective cohort study using NHS Blood and…”
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