Search Results - "Worthen, R"

Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: Polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs by Sarode, Ashish L., Wang, Peng, Obara, Sakae, Worthen, David R.

“…[Display omitted] The influence of polymers on the dissolution, supersaturation, crystallization, and partitioning of poorly water soluble compounds in…”
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Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review by Pardo, M., Cheng, Y., Sitbon, Y.H., Lowell, J.A., Grieco, S.F., Worthen, R.J., Desse, S., Barreda-Diaz, A.

“…[Display omitted] •The insulin growth factor 2 (IGF2) is abundantly expressed in the brain.•Inappropriate IGF2 expression is implicated in a growing number of…”
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Low-Viscosity Hydroxypropylcellulose (HPC) Grades SL and SSL: Versatile Pharmaceutical Polymers for Dissolution Enhancement, Controlled Release, and Pharmaceutical Processing by Sarode, Ashish, Wang, Peng, Cote, Catherine, Worthen, David R.

“…Hydroxypropylcellulose (HPC)-SL and -SSL, low-viscosity hydroxypropylcellulose polymers, are versatile pharmaceutical excipients. The utility of HPC polymers…”
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Education Policy Implications from the Expert Panel on Electronic Media and Youth Violence by Worthen, Maria R., M.S.W

“…Abstract The research from the Expert Panel on Electronic Media and Youth Violence makes a compelling case for why educators and education policymakers should…”
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The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L by Worthen, D R, Ghosheh, O A, Crooks, P A

“…A crude gum, a fixed oil and two purified components of Nigella sativa seed, thymoquinone (TQ) and dithymoquinone (DIM), were assayed in vitro for their…”
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Hydroxypropyl cellulose stabilizes amorphous solid dispersions of the poorly water soluble drug felodipine by Sarode, Ashish L., Malekar, Swapnil A., Cote, Catherine, Worthen, David R.

“…•ASDs of a poorly water soluble drug felodipine were prepared using HPC-SSL and PVP-VA.•Stability of these ASDs at various temperatures and humidity conditions…”
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A Little Life and Empathy Aptitude Reading by Worthen, Joseph R.

“…Reading literary fiction has long enjoyed a reputation as a constructive habit in American culture. It has been believed, at different times, to improve…”
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Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo by Jean-Gilles, Dinorah, Li, Liya, Vaidyanathan, V.G., King, Roberta, Cho, Bongsup, Worthen, David R., Chichester, Clinton O., Seeram, Navindra P.

“…•Polyphenol punicalagin inhibited type-II collagen degradation in vitro.•Punicalagin has multiple binding interactions with type-II collagen by SPR.•Molecular…”
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The Localization of Phenolic Compounds in Liposomal Bilayers and Their Effects on Surface Characteristics and Colloidal Stability by Malekar, Swapnil A., Sarode, Ashish L., Bach, Alvin C., Worthen, David R.

“…The interactions with and effects of five chemically distinct, bioactive phenolic compounds on the lipid bilayers of model dipalmitoylphosphatidylcholine…”
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An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine by Bence, Aimee K, Worthen, David R, Stables, James P, Crooks, Peter A

“…Agmatine, an endogenous cationic amine, exerts a wide range of biological effects, including modulation of glutamate-activated N-methyl- d-aspartate (NMDA)…”
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Radio Frequency-Activated Nanoliposomes for Controlled Combination Drug Delivery by Malekar, Swapnil A., Sarode, Ashish L., Bach, Alvin C., Bose, Arijit, Bothun, Geoffrey, Worthen, David R.

“…This work was conducted in order to design, characterize, and evaluate stable liposomes containing the hydrophobic drug raloxifene HCl (RAL) and hydrophilic…”
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A novel technique for visualizing the intracellular localization and distribution of transported polyamines in cultured pulmonary artery smooth muscle cells by Aziz, Shewan M, Yatin, Mustafa, Worthen, David R, Lipke, David W, Crooks, Peter A

“…The use of a combination of monofluorescein adducts of spermidine (FL-SPD) and spermine (FL-SPM) with confocal laser scanning microscopy (CLSM) provides a…”
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Regiospecific and conformationally restrained analogs of melphalan and dl-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood–brain barrier by Matharu, Jyothi, Oki, Jun, Worthen, David R., Smith, Quentin R., Crooks, Peter A.

“…Placing the mustard moiety at C-7 of the tetralin ring (5c) affords greatest affinity for the System LAT1 transporter; the more conformationally restrained…”
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The antiproliferative and immunotoxic effects of L-canavanine and L-canaline by Bence, Aimee K, Worthen, David R, Adams, Val R, Crooks, Peter A

“…L-Canavanine and its arginase-catalyzed metabolite, L-canaline, are two novel anticancer agents in development. Since the immunotoxic evaluation of agents in…”
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Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl- d-aspartate receptor complex by Bence, Aimee K, Rogers, Dennis T, Worthen, David R, Fu, May, Littleton, John M, Crooks, Peter A

“…As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-…”
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Endogenous indoles as novel polyamine site ligands at the N-methyl- d-aspartate receptor complex by Worthen, David R., Gibson, D.Alex, Rogers, Dennis T., Bence, Aimee K., Fu, May, Littleton, John M., Crooks, Peter A.

“…High-throughput ligand displacement screens of a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily displace […”
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Methods for the Recovery and Purification of Polyene Antifungals by Worthen, David R., Jay, Michael, Bummer, Paul M.

“…Despite the development of newer antifungal drugs, the polyene antifungals continue to be the most potent broad-spectrum fungicides available for clinical use…”
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Design, Synthesis, Antiviral Activity, and Pre-Formulation Development of Poly-L-Arginine-Fatty Acyl Derivatives of Nucleoside Reverse Transcriptase Inhibitors by Pemmaraju, Bhanu P., Malekar, Swapnil, Agarwal, Hitesh K., Tiwari, Rakesh K., Oh, Donghoon, Doncel, Gustavo F., Worthen, David R., Parang, Keykavous

“…The objective of this work was to design conjugates of anti-HIV nucleosides conjugated with fatty acids and cell-penetrating poly-L-arginine (polyArg)…”
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Nonprescription Drug Abuse by Conca, Addison J., Worthen, David R.

“…Nonprescription drug, also referred to as over-the-counter (OTC) abuse, is a serious and growing global health challenge. Drugs from many different therapeutic…”
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l-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines by Worthen, David R, Chien, Lynn, Tsuboi, Clifford P, Mu, Xi Y, Bartik, Mary M, Crooks, Peter A

“…l-Canavanine (L-CAV) is a naturally occurring l-arginine analog that induces the formation of non-functional proteins in a variety of organisms. Previous…”
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