Search Results - "Worrell, Roger T."

The use of murine‐derived fundic organoids in studies of gastric physiology by Schumacher, Michael A., Aihara, Eitaro, Feng, Rui, Engevik, Amy, Shroyer, Noah F., Ottemann, Karen M., Worrell, Roger T., Montrose, Marshall H., Shivdasani, Ramesh A., Zavros, Yana

“…Key points An in vitro approach to study gastric development is primary mouse‐derived epithelium cultured as three‐dimensional spheroids known as organoids. We…”
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slc26a3 (dra)-deficient Mice Display Chloride-losing Diarrhea, Enhanced Colonic Proliferation, and Distinct Up-regulation of Ion Transporters in the Colon by Schweinfest, Clifford W., Spyropoulos, Demetri D., Henderson, Kelly W., Kim, Jae-Ho, Chapman, Jeannie M., Barone, Sharon, Worrell, Roger T., Wang, Zhaohui, Soleimani, Manoocher

“…Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the molecular etiology of congenital chloride-losing diarrhea in humans. To…”
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Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo by Guan, Yanfang, Worrell, Roger T, Pritts, Timothy A, Montrose, Marshall H

“…The early events in an intestinal ischemic episode have been difficult to evaluate. Using in vivo microscopy we have analyzed in real-time the effects of short…”
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Acidic Conditions in the NHE2-/- Mouse Intestine Result in an Altered Mucosa-Associated Bacterial Population with Changes in Mucus Oligosaccharides by Engevik, Melinda A., Hickerson, Annelies, Shull, Gary E., Worrell, Roger T.

“…Background: The mechanisms bacteria use to proliferate and alter the normal bacterial composition remain unknown. The ability to link changes in the intestinal…”
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Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct by Ishiguro, Hiroshi, Namkung, Wan, Yamamoto, Akiko, Wang, Zhaohui, Worrell, Roger T, Xu, Jie, Lee, Min Goo, Soleimani, Manoocher

“…The role of Slc26a6 (PAT1) on apical Cl-/HCO3- exchange and bicarbonate secretion in pancreatic duct cells was investigated using Slc26a6 null and wild-type…”
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Prebiotic Properties of Galursan HF 7K on Mouse Gut Microbiota by Engevik, Melinda A., Faletti, Carla J., Paulmichl, Markus, Worrell, Roger T.

“…Background: With the rise of antibiotic resistance, new alternatives are being sought to effectively modulate the characteristics of gut microbiota to obtain…”
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Human Clostridium difficile infection: altered mucus production and composition by Engevik, Melinda A, Yacyshyn, Mary Beth, Engevik, Kristen A, Wang, Jiang, Darien, Benjamin, Hassett, Daniel J, Yacyshyn, Bruce R, Worrell, Roger T

“…The majority of antibiotic-induced diarrhea is caused by Clostridium difficile (C. difficile). Hospitalizations for C. difficile infection (CDI) have tripled…”
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Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis by Li, Hong C, Szigligeti, Peter, Worrell, Roger T, Matthews, Jeffrey B, Conforti, Laura, Soleimani, Manoocher

“…The kidney Na(+):HCO(3)(-) cotransporter NBC1 is located exclusively on the basolateral membrane of kidney proximal tubule cells and is responsible for the…”
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Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese by Shawki, Ali, Anthony, Sarah R, Nose, Yasuhiro, Engevik, Melinda A, Niespodzany, Eric J, Barrientos, Tomasa, Öhrvik, Helena, Worrell, Roger T, Thiele, Dennis J, Mackenzie, Bryan

“…Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron…”
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Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile by Engevik, Melinda A, Engevik, Kristen A, Yacyshyn, Mary Beth, Wang, Jiang, Hassett, Daniel J, Darien, Benjamin, Yacyshyn, Bruce R, Worrell, Roger T

“…Clostridium difficile infection (CDI) is principally responsible for hospital acquired, antibiotic-induced diarrhea and colitis and represents a significant…”
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Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth by Engevik, Melinda A, Aihara, Eitaro, Montrose, Marshall H, Shull, Gary E, Hassett, Daniel J, Worrell, Roger T

“…Changes in the intestinal microbiota have been linked to diabetes, obesity, inflammatory bowel disease, and Clostridium difficile (C. difficile)-associated…”
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Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins by Yoo, James, Nichols, Anthony, Mammen, Joshua, Calvo, Isabel, Song, Jaekyung C, Worrell, Roger T, Matlin, Karl, Matthews, Jeffrey B

“…Protein kinase C (PKC) is known to regulate epithelial barrier function. However, the effect of specific PKC isozymes, and their mechanism of action, are…”
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Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse by Shawki, Ali, Engevik, Melinda A, Kim, Robert S, Knight, Patrick B, Baik, Rusty A, Anthony, Sarah R, Worrell, Roger T, Shull, Gary E, Mackenzie, Bryan

“…Divalent metal-ion transporter-1 (DMT1), the principal mechanism by which nonheme iron is taken up at the intestinal brush border, is energized by the…”
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889 NHE2−/− Mice Have Altered Intestinal Microbiota and Epithelia Oligosaccharide Patterns by Engevik, Melinda A, Shull, Gary, Worrell, Roger T

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Contrasting effects of cPLA2 on epithelial Na+ transport by Worrell, R T, Bao, H F, Denson, D D, Eaton, D C

“…Activity of the epithelial Na+ channel (ENaC) is the limiting step for discretionary Na+ reabsorption in the cortical collecting duct. Xenopus laevis kidney A6…”
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Gastritis Promotes an Activated Bone Marrow-Derived Mesenchymal Stem Cell with a Phenotype Reminiscent of a Cancer-Promoting Cell by Donnelly, Jessica M., Engevik, Amy C., Engevik, Melinda, Schumacher, Michael A., Xiao, Chang, Yang, Li, Worrell, Roger T., Zavros, Yana

“…Background Bone marrow-derived mesenchymal stem cells (BM-MSCs) promote gastric cancer in response to gastritis. In culture, BM-MSCs are prone to mutation with…”
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Sa1276 Altered Mucus Oligosaccharide Composition in Human C. difficile Infection by Engevik, Melinda A, Yacyshyn, Mary Beth, Yacyshyn, Bruce, Hassett, Daniel J, Worrell, Roger T

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Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1 by Worrell, Roger T, Merk, Lisa, Matthews, Jeffrey B

“…Although colonic lumen NH(4)(+) levels are high, 15-44 mM normal range in humans, relatively few studies have addressed the transport mechanisms for NH(4)(+)…”
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Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway by Mykoniatis, Andreas, Shen, Le, Fedor-Chaiken, Mary, Tang, Jun, Tang, Xu, Worrell, Roger T, Delpire, Eric, Turner, Jerrold R, Matlin, Karl S, Bouyer, Patrice, Matthews, Jeffrey B

“…In secretory epithelial cells, the basolateral Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) plays a major role in salt and fluid secretion. Our laboratory has…”
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Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion by JIE XU, WORRELL, Roger T, LI, Hong C, BARONE, Sharon L, PETROVIC, Snezana, AMLAL, Hassane, SOLEIMANI, Manoocher

“…SLC26A7 is a Cl(-)/HCO(3)(-) exchanger that is expressed on the basolateral membrane and in the cytoplasm of two distinct acid-secreting epithelial cells: The…”
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