Search Results - "Wormstone, Ian Michael"

Sulforaphane can protect lens cells against oxidative stress: implications for cataract prevention by Liu, Hanruo, Smith, Andrew J O, Lott, Martin C, Bao, Yongping, Bowater, Richard P, Reddan, John R, Wormstone, Ian Michael

“…Protecting the lens against oxidative stress is of great importance in delaying the onset of cataract. Isothiocyanates, such as sulforaphane (SFN), are…”
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Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells by Liu, Peng, Wang, Wei, Zhou, Zhigang, Smith, Andrew J O, Bowater, Richard P, Wormstone, Ian Michael, Chen, Yuqiong, Bao, Yongping

“…Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites…”
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Experimental models for posterior capsule opacification research by Wormstone, Ian Michael, Eldred, Julie Ann

“…Millions of people worldwide are blinded due to cataract formation. At present the only means of treating a cataract is through surgical intervention. A modern…”
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Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery by Dawes, Lucy Jean, Duncan, George, Wormstone, Ian Michael

“…Cataract surgery is blighted by posterior capsule opacification (PCO), which is more severe and frequent in the young than the elderly (>60 years). Our aim was…”
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Lens Cell Survival after Exposure to Stress in the Closed Capsular Bag by Duncan, George, Wang, Lixin, Neilson, Geoffrey J, Wormstone, Ian Michael

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Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lens by Smith, Andrew John Oliver, Ball, Simon Sidney Robert, Manzar, Kamal, Bowater, Richard Peter, Wormstone, Ian Michael

“…Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The…”
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AGEs in human lens capsule promote the TGFβ2‐mediated EMT of lens epithelial cells: implications for age‐associated fibrosis by Raghavan, Cibin T., Smuda, Mareen, Smith, Andrew J. O., Howell, Scott, Smith, Dawn G., Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A., Wormstone, Ian Michael, Nagaraj, Ram H.

“…Summary Proteins in basement membrane (BM) are long‐lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is…”
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TGFβ/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells by JEAN DAWES, Lucy, ALEXANDER SLEEMAN, Matthew, ANDERSON, Ian Keith, REDDAN, John R, WORMSTONE, Ian Michael

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Lens cell survival after exposure to stress in the closed capsular bag by DUNCAN, George, LIXIN WANG, NEILSON, Geoffrey J, WORMSTONE, Ian Michael

“…Despite recent improvements in IOL design posterior capsule opacification (PCO) remains a significant clinical problem after cataract surgery. The Perfect…”
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AGEs in human lens capsule promote the TGF[beta]2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis by Raghavan, Cibin T, Smuda, Mareen, Smith, Andrew J O, Howell, Scott, Smith, Dawn G, Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A, Wormstone, Ian Michael, Nagaraj, Ram H

“…Summary Proteins in basement membrane (BM) are long-lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is…”
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TGF beta-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or alpha SMA expression by Dawes, Lucy Jean, Eldred, Julie Ann, Anderson, Ian Kevin, Sleeman, Matthew, Reddan, John R, Duncan, George, Wormstone, Ian Michael

“…Transforming growth factor (TGF)-beta is a potent inducer of both transdifferentiation and contraction, which are regarded as critical processes that underpin…”
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TGFβ-Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or aSMA Expression by DAWES, Lucy Jean, ELDRED, Julie Ann, ANDERSON, Ian Kevin, SLEEMAN, Matthew, REDDAN, John R, DUNCAN, George, WORMSTONE, Ian Michael

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TGFbeta/Smad4-dependent and -independent regulation of human lens epithelial cells by Dawes, Lucy Jean, Sleeman, Matthew Alexander, Anderson, Ian Keith, Reddan, John R, Wormstone, Ian Michael

“…Transforming growth factor (TGF)-beta can mediate fibrotic responses via Smad4-dependent and -independent signaling pathways. TGFbeta-induced…”
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TGF{beta}/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells by Dawes, Lucy Jean, Sleeman, Matthew Alexander, Anderson, Ian Keith, Reddan, John R, Wormstone, Ian Michael

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TGF{beta}-Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or {alpha}SMA Expression by Dawes, Lucy Jean, Eldred, Julie Ann, Anderson, Ian Kevin, Sleeman, Matthew, Reddan, John R, Duncan, George, Wormstone, Ian Michael

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