Search Results - "Wormald, Mark"

Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs by Zhang, Peiqing, Woen, Susanto, Wang, Tianhua, Liau, Brian, Zhao, Sophie, Chen, Chen, Yang, Yuansheng, Song, Zhiwei, Wormald, Mark R., Yu, Chuanfei, Rudd, Pauline M.

“…•Glycosylation of antibodies has a range of effects on their binding and effector functions.•Regulatory agencies require stringent glycan analysis to ensure…”
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The impact of glycosylation on the biological function and structure of human immunoglobulins by Arnold, James N, Wormald, Mark R, Sim, Robert B, Rudd, Pauline M, Dwek, Raymond A

“…Immunoglobulins are the major secretory products of the adaptive immune system. Each is characterized by a distinctive set of glycoforms that reflects the wide…”
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The Role and Importance of Glycosylation of Acute Phase Proteins with Focus on Alpha‑1 Antitrypsin in Acute and Chronic Inflammatory Conditions by McCarthy, Cormac, Saldova, Radka, Wormald, Mark R, Rudd, Pauline M, McElvaney, Noel G, Reeves, Emer P

“…Acute phase proteins (APPs) are a group of circulating plasma proteins which undergo changes quantitatively or qualitatively at the time of inflammation. Many…”
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High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations by Pučić, Maja, Knežević, Ana, Vidič, Jana, Adamczyk, Barbara, Novokmet, Mislav, Polašek, Ozren, Gornik, Olga, Šupraha-Goreta, Sandra, Wormald, Mark R., Redžić, Irma, Campbell, Harry, Wright, Alan, Hastie, Nicholas D., Wilson, James F., Rudan, Igor, Wuhrer, Manfred, Rudd, Pauline M., Josić, Djuro, Lauc, Gordan

“…All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in N-glycosylation of IgG associate with various diseases and…”
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A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application by O'Brien, Michael E, Murray, Grace, Gogoi, Debananda, Yusuf, Azeez, McCarthy, Cormac, Wormald, Mark R, Casey, Michelle, Gabillard-Lefort, Claudie, McElvaney, Noel G, Reeves, Emer P

“…Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its…”
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Fc gamma receptors: glycobiology and therapeutic prospects by Hayes, Jerrard M, Wormald, Mark R, Rudd, Pauline M, Davey, Gavin P

“…Therapeutic antibodies hold great promise for the treatment of cancer and autoimmune diseases, and developments in antibody-drug conjugates and bispecific…”
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Comprehensive N-Glycan Profiling of Avian Immunoglobulin Y by Gilgunn, Sarah, Millán Martín, Silvia, Wormald, Mark R, Zapatero-Rodríguez, Julia, Conroy, Paul J, O'Kennedy, Richard J, Rudd, Pauline M, Saldova, Radka

“…Recent exploitation of the avian immune system has highlighted its suitability for the generation of high-quality, high-affinity antibodies to a wide range of…”
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d-Idose, d-Iduronic Acid, and d-Idonic Acid from d-Glucose via Seven-Carbon Sugars by Liu, Zilei, Jenkinson, Sarah F, Yoshihara, Akihide, Wormald, Mark R, Izumori, Ken, Fleet, George W J

“…A practical synthesis of the very rare sugar d-idose and the stable building blocks for d-idose, d-iduronic, and d-idonic acids from -heptonic acid requires…”
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Benefits of Simulations as Remote Exercises During the COVID-19 Pandemic: An Enzyme Kinetics Case Study by Worrall, Andrew F, Bergstrom Mann, Patrick E, Young, Damion, Wormald, Mark R, Cahill, Samuel T, Stewart, Malcolm I

“…Teaching practical chemistry skills remotely is not a task that would have been high on the agenda only a few months ago. However, in light of the COVID-19…”
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Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei by Mehlert, Angela, Wormald, Mark R, Ferguson, Michael A J

“…The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance…”
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The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling by O'Dwyer, Ciara A, O'Brien, M Emmet, Wormald, Mark R, White, Michelle M, Banville, Nessa, Hurley, Killian, McCarthy, Cormac, McElvaney, Noel G, Reeves, Emer P

“…Leukotriene B4 (LTB4) contributes to many inflammatory diseases, including genetic and nongenetic forms of chronic obstructive pulmonary disease. α-1…”
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nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity by Doores, Katie J, Fulton, Zara, Hong, Vu, Patel, Mitul K, Scanlan, Christopher N, Wormald, Mark R, Finn, M.G, Burton, Dennis R, Wilson, Ian A, Davis, Benjamin G

“…Antibody 2G12 uniquely neutralizes a broad range of HIV-1 isolates by binding the high-mannose glycans on the HIV-1 surface glycoprotein, gp120. Antigens that…”
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3‑Fluoroazetidinecarboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar by Liu, Zilei, Jenkinson, Sarah F, Vermaas, Tom, Adachi, Isao, Wormald, Mark R, Hata, Yukako, Kurashima, Yukiko, Kaji, Akira, Yu, Chu-Yi, Kato, Atsushi, Fleet, George W. J

“…Reverse aldol opening renders amides of 3-hydroxyazetidinecarboxylic acids (3-OH-Aze) unstable above pH 8. Aze, found in sugar beet, is mis-incorporated for…”
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At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody by Yu, Chuanfei, Gao, Kai, Zhu, Lei, Wang, Wenbo, Wang, Lan, Zhang, Feng, Liu, Chunyu, Li, Meng, Wormald, Mark R., Rudd, Pauline M., Wang, Junzhi

“…Two non-human glycan epitopes, galactose-α-1,3-galactose (α-gal) and Neu5Gc-α-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab…”
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Glycosylation changes on serum glycoproteins in ovarian cancer may contribute to disease pathogenesis by Saldova, Radka, Wormald, Mark R, Dwek, Raymond A, Rudd, Pauline M

“…Ovarian cancer is the most lethal of all gynaecological cancers among women. Serum CA125 is the only biomarker that is used routinely and there is a need for…”
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Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition by Calarese, Daniel A., Scanlan, Christopher N., Zwick, Michael B., Deechongkit, Songpon, Mimura, Yusuke, Kunert, Renate, Zhu, Ping, Wormald, Mark R., Stanfield, Robyn L., Roux, Kenneth H., Kelly, Jeffery W., Rudd, Pauline M., Dwek, Raymond A., Katinger, Hermann, Burton, Dennis R., Wilson, Ian A.

“…Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1 (HIV-1) isolates by binding an unusually dense cluster of carbohydrate…”
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Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity by Reeves, Emer P, Dunlea, Danielle M, McQuillan, Karen, O'Dwyer, Ciara A, Carroll, Tomás P, Saldova, Radka, Akepati, Prithvi Reddy, Wormald, Mark R, McElvaney, Oliver J, Shutchaidat, Vipatsorn, Henry, Michael, Meleady, Paula, Keenan, Joanne, Liberti, Derek C, Kotton, Darrell N, Rudd, Pauline M, Wilson, Andrew A, McElvaney, Noel G

“…Alpha-1 antitrypsin (AAT) is an acute phase protein that possesses immune-regulatory and anti-inflammatory functions independent of antiprotease activity. AAT…”
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Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of d‑Gulose, 6‑Deoxy‑d‑gulose, l‑Glucose, 6‑Deoxy‑l‑glucose, and Related Sugars by Liu, Zilei, Yoshihara, Akihide, Jenkinson, Sarah F, Wormald, Mark R, Estévez, Ramón J, Fleet, George W. J, Izumori, Ken

“…Ease of separation of petrol-soluble acetonides derived from the triacetonide of methyl glucoheptonate allows scalable syntheses of rare sugars containing the…”
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Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations by Reeves, Emer P, O'Dwyer, Ciara A, Dunlea, Danielle M, Wormald, Mark R, Hawkins, Padraig, Alfares, Mohammad, Kotton, Darrell N, Rowe, Steven M, Wilson, Andrew A, McElvaney, Noel G

“…After sequencing of all coding exons (II-V) of the SERPINA1 gene, the patient was identified as homozygous for the Q0bolton mutation, with two PTCs at amino…”
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The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120 by Scanlan, Christopher N, Pantophlet, Ralph, Wormald, Mark R, Ollmann Saphire, Erica, Stanfield, Robyn, Wilson, Ian A, Katinger, Hermann, Dwek, Raymond A, Rudd, Pauline M, Burton, Dennis R

“…2G12 is a broadly neutralizing human monoclonal antibody against human immunodeficiency virus type-1 (HIV-1) that has previously been shown to bind to a…”
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