Search Results - "Worm, Karl"

MGMT-Methylation in Non-Neoplastic Diseases of the Central Nervous System by Teuber-Hanselmann, Sarah, Worm, Karl, Macha, Nicole, Junker, Andreas

“…Quantifying O -methylguanine-DNA methyltransferase (MGMT) promoter methylation plays an essential role in assessing the potential efficacy of alkylating agents…”
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Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation by Heydt, Carina, Wölwer, Christina B, Velazquez Camacho, Oscar, Wagener-Ryczek, Svenja, Pappesch, Roberto, Siemanowski, Janna, Rehker, Jan, Haller, Florian, Agaimy, Abbas, Worm, Karl, Herold, Thomas, Pfarr, Nicole, Weichert, Wilko, Kirchner, Thomas, Jung, Andreas, Kumbrink, Jörg, Goering, Wolfgang, Esposito, Irene, Buettner, Reinhard, Hillmer, Axel M, Merkelbach-Bruse, Sabine

“…Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. Five…”
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KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors - TORC1/2 Inhibition as Salvage Strategy by Mühlenberg, Thomas, Ketzer, Julia, Heinrich, Michael C, Grunewald, Susanne, Marino-Enriquez, Adrian, Trautmann, Marcel, Hartmann, Wolfgang, Wardelmann, Eva, Treckmann, Jürgen, Worm, Karl, Bertram, Stefanie, Herold, Thomas, Schildhaus, Hans-Ulrich, Glimm, Hanno, Stenzinger, Albrecht, Brors, Benedikt, Horak, Peter, Hohenberger, Peter, Fröhling, Stefan, Fletcher, Jonathan A, Bauer, Sebastian

“…Sporadic gastrointestinal stromal tumors (GIST), characterized by activating mutations of or , favorably respond to KIT inhibitory treatment but eventually…”
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Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status by Broecker-Preuss, Martina, Müller, Stefan, Britten, Martin, Worm, Karl, Schmid, Kurt Werner, Mann, Klaus, Fuhrer, Dagmar

“…Patients with dedifferentiated or anaplastic thyroid carcinomas currently lack appropriate treatment options. Kinase inhibitors are among the most promising…”
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Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer patients by Breitenbuecher, Frank, Hoffarth, Sandra, Worm, Karl, Cortes-Incio, Diana, Gauler, Thomas C, Köhler, Jens, Herold, Thomas, Schmid, Kurt Werner, Freitag, Lutz, Kasper, Stefan, Schuler, Martin

“…Oncogenic mutations are powerful predictive biomarkers for molecularly targeted cancer therapies. For mutation detection patients have to undergo invasive…”
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Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements by Sheu, Sien-Yi, Schwertheim, Suzan, Worm, Karl, Grabellus, Florian, Schmid, Kurt Werner

“…Diffuse sclerosing variant of papillary thyroid carcinoma (PTC) is a rare tumour with a characteristic morphology as well as a strong preponderance for younger…”
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Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy by Kasper, Stefan, Reis, Henning, Ziegler, Sophie, Nothdurft, Silke, Mueller, Andre, Goetz, Moritz, Wiesweg, Marcel, Phasue, Jeannette, Ting, Saskia, Wieczorek, Sarah, Even, Anna, Worm, Karl, Pogorzelski, Michael, Breitenbuecher, Sandra, Meiler, Johannes, Paul, Andreas, Trarbach, Tanja, Schmid, Kurt Werner, Breitenbuecher, Frank, Schuler, Martin

“…Monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), cetuximab and panitumumab, are a mainstay of metastatic colorectal cancer (mCRC)…”
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Loss of heterozygosity proximal to the M6P/IGF2R locus is predictive for the presence of disseminated tumor cells in the bone marrow of ovarian cancer patients before and after chemotherapy by Kuhlmann, Jan Dominik, Schwarzenbach, Heidi, Otterbach, Friedrich, Heubner, Martin, Wimberger, Pauline, Worm, Karl-Heinz, Kimmig, Rainer, Kasimir-Bauer, Sabine

“…Disseminated tumor cells (DTC) in the bone marrow (BM) are present in about 35% of ovarian cancers before surgery and after chemotherapy and are associated…”
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Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon by Schmitz, Klaus Juergen, Hey, Sascha, Schinwald, Anja, Wohlschlaeger, Jeremias, Baba, Hideo Andreas, Worm, Karl, Schmid, Kurt Werner

“…This study was designed to analyse the potential diagnostic value of miR-181b and miR-21 for discriminating hyperplastic polyps (HP) from sessile serrated…”
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Defining tissue requirements for a reliable detection of tumor mutational burden (TMB) in clinical FFPE samples by Schildhaus, Hans-Ulrich, Herold, Thomas, Worm, Karl, Stoss, Oliver

“…Abstract only e14265 Background: In the context of immuno-oncology related cancer treatment, tumor mutational burden (TMB) is currently explored as a…”
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Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells by Schwertheim, Suzan, Wein, Frederik, Lennartz, Klaus, Worm, Karl, Schmid, Kurt Werner, Sheu-Grabellus, Sien-Yi

“…Purpose The therapy of unresectable advanced thyroid carcinomas shows unfavorable outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid…”
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Reverse transcriptase polymerase chain reaction as a reliable method to detect epidermal growth factor receptor exon 2–7 gene deletion in human glioblastomas by Worm, Karl, Dabbagh, Peter, Schwechheimer, Karl

“…Epidermal growth factor receptor (EGFR) gene amplification has been reported to occur in diverse carcinoma types such as lung, ovarian, and breast carcinomas…”
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Impact of RAS mutation subtype on clinical outcome—a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer by Wiesweg, Marcel, Kasper, Stefan, Worm, Karl, Herold, Thomas, Reis, Henning, Sara, Linda, Metzenmacher, Martin, Abendroth, Annalena, Darwiche, Kaid, Aigner, Clemens, Wedemeyer, Heiner H., Helfritz, Fabian A., Stuschke, Martin, Schumacher, Brigitte, Markus, Peter, Paul, Andreas, Rahmann, Sven, Schmid, Kurt W., Schuler, Martin

“…Mutated RAS onco-proteins are key drivers across many cancers. The distribution of somatic RAS mutations varies between cancer entities. Retrospective analyses…”
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Exercise during pregnancy mitigates Alzheimer‐like pathology in mouse offspring by Herring, Arne, Donath, Anja, Yarmolenko, Maksym, Uslar, Ellen, Conzen, Catharina, Kanakis, Dimitrios, Bosma, Claudius, Worm, Karl, Paulus, Werner, Keyvani, Kathy

“…ABSTRACT Physical activity protects brain function in healthy individuals and those with Alzheimer's disease (AD). Evidence for beneficial effects of parental…”
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Quantification of G Protein Gαs Subunit Splice Variants in Different Human Tissues and Cells Using Pyrosequencing by FREY, ULRICH H., NÜCKEL, HOLGER, DOBREV, DOBROMIR, MANTHEY, IRIS, SANDALCIOGLU, I. E., EISENHARDT, ANDREAS, KARL, WORM, HANS, HAUNER, SIFFERT, WINFRIED

“…The G protein Gαs is derived from four alternatively spliced transcripts, two long variants (GαsL+CAG and GαsL−CAG), which include an extra 45-bp segment, and…”
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Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study by Mairinger, Fabian Dominik, Ting, Saskia, Werner, Robert, Walter, Robert Fred Henry, Hager, Thomas, Vollbrecht, Claudia, Christoph, Daniel, Worm, Karl, Mairinger, Thomas, Sheu-Grabellus, Sien-Yi, Theegarten, Dirk, Schmid, Kurt Werner, Wohlschlaeger, Jeremias

“…MicroRNAs (miRNAs) are a class of small (∼22 nucleotides), non-coding, highly conserved single-stranded RNAs with posttranscriptional regulatory features,…”
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High Prevalence of Concomitant Oncogene Mutations in Prospectively Identified Patients with ROS1-Positive Metastatic Lung Cancer by Wiesweg, Marcel, Eberhardt, Wilfried E E, Reis, Henning, Ting, Saskia, Savvidou, Nikoleta, Skiba, Charlotte, Herold, Thomas, Christoph, Daniel C, Meiler, Johannes, Worm, Karl, Kasper, Stefan, Theegarten, Dirk, Hense, Jörg, Hager, Thomas, Darwiche, Kaid, Oezkan, Filiz, Aigner, Clemens, Welter, Stefan, Kühl, Hilmar, Stuschke, Martin, Schmid, Kurt W, Schuler, Martin

“…Chromosomal rearrangements involving ROS1 define a rare entity of lung adenocarcinomas with exquisite sensitivity to molecularly targeted therapy. We report…”
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Papilloma of the Fallopian Tube: A Rare Gynecologic Neoplasm Harboring a BRAF (c.1799T>A) Mutation (V600E) by Wohlschlaeger, Jeremias, Davidson, Ben, Worm, Karl, Feist, Henning, Peters, Jochen, Hager, Thomas, Schmid, Kurt W, Ostertag, Horst

“…Papillomas of the fallopian tube are exceedingly rare benign tumors, and only very few cases have been reported in the literature. Clinically, they may present…”
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Prognostic markers and response to vandetanib therapy in sporadic medullary thyroid cancer patients by Tiedje, Vera, Ting, Saskia, Walter, Robert Fred, Herold, Thomas, Worm, Karl, Badziong, Julia, Zwanziger, Denise, Schmid, Kurt Werner, Führer, Dagmar

“…Objective Medullary thyroid carcinoma (MTC) occurs sporadically in 75% of patients. Metastatic disease is associated with significantly poorer survival. The…”
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Intermediate microRNA expression profile in Graves' disease falls between that of normal thyroid tissue and papillary thyroid carcinoma by Pohl, Matthias, Grabellus, Florian, Worm, Karl, Arnold, Georg, Walz, Martin, Schmid, Kurt Werner, Sheu-Grabellus, Sien-Yi

“…Many studies have previously reported a higher prevalence of papillary thyroid carcinomas (PTC) in patients with Graves' disease (GD). MicroRNAs (miRNAs) are…”
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