Search Results - "Worland, Peter J."

Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism by ESCOUBET-LOZACH, Laure, LIN, I-Lin, JENSEN-PERGAKES, Kristen, BRADY, Helen A, GANDHI, Anita K, SCHAFER, Peter H, MULLER, George W, WORLAND, Peter J, CHAN, Kyle W. H, VERHELLE, Dominique

“…Lenalidomide and pomalidomide have both been evaluated clinically for their properties as anticancer agents, with lenalidomide being available commercially. We…”
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A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer by HENRY, Michael D, SHENGHUA WEN, SILVA, Matthew D, CHANDRA, Sudeep, MILTON, Mark, WORLAND, Peter J

“…MLN2704 is an antibody-chemotherapeutic conjugate designed to target prostate-specific membrane antigen (PSMA). PSMA is a transmembrane receptor whose…”
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Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells by CARLSON, B. A, DUBAY, M. M, SAUSVILLE, E. A, BRIZUELA, L, WORLAND, P. J

“…Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and is a potent cyclin-dependent…”
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Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol by CARLSON, B, LAHUSEN, T, SINGH, S, LOAIZA-PEREZ, A, WORLAND, P. J, PESTELL, R, ALBANESE, C, SAUSVILLE, E. A, SENDEROWICZ, A. M

“…Flavopiridol is a novel flavonoid that induces cell cycle arrest at different stages of the cell cycle because of the inhibition of cyclin-dependent kinases…”
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UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53 by Wang, Qizhi, Fan, Saijun, Eastman, Alan, Worland, Peter J., Sausville, Edward A., O'Connor, Patrick M.

“…Background: Arrest of the cell cycle in G2 phase following DNA damage helps protect cell viability by allowing time for DNA repair before entry into mitosis (M…”
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Anticancer antibodies by ROSS, Jeffrey S, GRAY, Karen, GRAY, Gary S, WORLAND, Peter J, ROLFE, Mark

“…The recent clinical and commercial success of anticancer antibodies such as rituximab and trastuzumab has created great interest in antibody-based therapeutics…”
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Structural Basis for Specificity and Potency of a Flavonoid Inhibitor of Human CDK2, a Cell Cycle Kinase by De Azevedo, Walter Filgueira, Mueller-Dieckmann, Hans-Joachim, Schulze-Gahmen, Ursula, Worland, Peter J., Sausville, Edward, Kim, Sung-Hou

“…The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify…”
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Spiculated periosteal response induced by intraosseous injection of 22Rv1 prostate cancer cells resembles subset of bone metastases in prostate cancer patients by Henry, Michael D., Silva, Matthew D., Wen, Shenghua, Siebert, Elizabeth, Solin, Edward, Chandra, Sudeep, Worland, Peter J.

“…Background Prostate cancer bone metastasis is distinguished by the predominance of osteoblastic lesions. This phenotype has been difficult to reproduce in…”
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Antibody-based therapeutics in oncology by Ross, Jeffrey S, Gray, Karen, Schenkein, David, Greene, Barry, Gray, Gary S, Shulok, Jeanine, Worland, Peter J, Celniker, Abbie, Rolfe, Mark

“…The recent clinical and commercial success of anticancer antibodies, such as rituximab (Rituxan®) and trastuzumab (Herceptin®) has created great interest in…”
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Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60 Tyrosine Kinase by Edward G. Mimnaugh, Peter J. Worland, Luke Whitesell, Leonard M. Neckers

“…The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60 , directs its…”
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The Gastrin-releasing Peptide Receptor Is Rapidly Phosphorylated by a Kinase Other Than Protein Kinase C After Exposure to Agonist (∗) by Kroog, Glenn S., Sainz, Eduardo, Worland, Peter J., Akeson, Mark A., Benya, Richard V., Jensen, Robert T., Battey, James F.

“…Several guanine nucleotide-binding protein-coupled receptors are known to be rapidly phosphorylated after agonist exposure. In this study we show that the…”
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Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60v-src Tyrosine Kinase () by Mimnaugh, Edward G., Worland, Peter J., Whitesell, Luke, Neckers, Leonard M.

“…The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60v-src, directs…”
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Radioimmunoassay for the quantitation of lisinopril and enalaprilat by Worland, P J, Jarrott, B

“…A sensitive radioimmunoassay (RIA) capable of measuring either lisinopril (1-[N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl] -L-proline) or enalaprilat…”
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Expression of growth-related genes during tumor progression in v-raf-transformed rat liver epithelial cells by HAMPTON, L. L, WORLAND, P. J, YU, B, THORGEIRSSON, S. S, HUGGETT, A. C

“…Clonal cell lines were derived from rat liver epithelial cells following their transformation with either v-raf or v-raf/v-myc. Cells transformed with v-raf…”
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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275 by Losiewicz, M D, Carlson, B A, Kaur, G, Sausville, E A, Worland, P J

“…L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase…”
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Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue by Seynaeve, C M, Kazanietz, M G, Blumberg, P M, Sausville, E A, Worland, P J

“…UCN-01 (7-hydroxystaurosporine) has been demonstrated to be a potent inhibitor of tumor cell growth both in cell culture and with in vivo xenograft models. The…”
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Structure-activity relationship studies of flavopiridol analogues by Murthi, K K, Dubay, M, McClure, C, Brizuela, L, Boisclair, M D, Worland, P J, Mansuri, M M, Pal, K

“…Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic…”
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Spiculated periosteal response induced by intraosseous injection of 22Rvl prostate cancer cells resembles subset of bone metastases in prostate cancer patients by HENRY, Michael D, SILVA, Matthew D, SHENGHUA WEN, SIEBERT, Elizabeth, SOLIN, Edward, CHANDRA, Sudeep, WORLAND, Peter J

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Potentiation of human vascular smooth muscle contraction by angiotensin by Moulds, R F, Worland, P J

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Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells by SEYNAEVE, C. M, STETLER-STEVENSON, M, SEBERS, S, KAUR, G, SAUSVILLE, E. A, WORLAND, P. J

“…UCN-01 is a derivative of staurosporine, initially developed as a potentially selective inhibitor of the Ca(2+)- and phospholipid-dependent protein kinase C,…”
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