Search Results - "Worgul, B. V."

Cataracts among Chernobyl Clean-up Workers: Implications Regarding Permissible Eye Exposures by Worgul, B. V., Kundiyev, Y. I., Sergiyenko, N. M., Chumak, V. V., Vitte, P. M., Medvedovsky, C., Bakhanova, E. V., Junk, A. K., Kyrychenko, O. Y., Musijachenko, N. V., Shylo, S. A., Vitte, O. P., Xu, S., Xue, X., Shore, R. E.

“…Worgul, B. V., Kundiyev, Y. I., Sergiyenko, N. M., Chumak, V. V., Vitte, P. M., Medvedovsky, C., Bakhanova, E. V., Junk, A. K., Kyrychenko, O. Y.,…”
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Dosimetry for a Study of Low-Dose Radiation Cataracts among Chernobyl Clean-up Workers by Chumak, V. V., Worgul, B. V., Kundiyev, Y. I., Sergiyenko, N. M., Vitte, P. M., Medvedovsky, C., Bakhanova, E. V., Junk, A. K., Kyrychenko, O. Y., Musijachenko, N. V., Sholom, S. V., Shylo, S. A., Vitte, O. P., Xu, S., Xue, X., Shore, R. E.

“…Chumak, V. V., Worgul, B. V., Kundiyev, Y. I., Sergiyenko, N. M., Vitte, P. M., Medvedovsky, C., Bakhanova, E. V., Junk, A. K., Kyrychenko, O. Y.,…”
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Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes by Worgul, B.V., Smilenov, L., Brenner, D.J., Vazquez, M., Hall, E.J.

“…Previous studies have shown that the eyes of ATM heterozygous mice exposed to low-LET radiation (X-rays) are significantly more susceptible to the development…”
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Quantitative Assessment of the Cataractogenic Potential of Very Low Doses of Neutrons by Worgul, Basil V., Medvedovsky, Cecily, Huang, Youping, Marino, Stephen A., Randers-Pehrson, Gerhard, Brenner, David J.

“…We report on the prevalence and relative biological effectiveness (RBE) for various stages of lens opacification in rats induced by very low doses (2 to 250…”
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Accelerated Heavy Particles and the Lens: VIII. Comparisons between the Effects of Acute Low Doses of Iron Ions (190 keV/μm) and Argon Ions (88 keV/μm) by Brenner, D. J., Medvedovsky, C., Huang, Y., Worgul, B. V.

“…The nature of the RBE-LET relationship for radiation-induced effects in vivo is not well known in the high-LET range above about 100 keV/μm. Here, we compare…”
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Quantitative comparisons of continuous and pulsed low dose rate regimens in a model late-effect system by Brenner, D J, Hall, E J, Randers-Pehrson, G, Huang, Y, Johnson, G W, Miller, R W, Wu, B, Vazquez, M E, Medvedovsky, C, Worgul, B V

“…There is increasing interest and usage of pulsed low dose rate (PDR) brachytherapy, in which a single source is shuttled through the catheters of an implant,…”
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Atm Heterozygous Mice are More Sensitive to Radiation-Induced Cataracts Than are Their Wild-Type Counterparts by Worgul, Basil V., Smilenov, Lubomir, Brenner, David J., Junk, Anna, Zhou, Wei, Hall, Eric J.

“…It is important to know whether the human population includes genetically predisposed radiosensitive subsets. In vitro studies have shown that cells from…”
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Neutron Effects on the Lens by Medvedovsky, C., Worgul, B. V.

“…Few in vivo systems have received the investigative attention or have provided the grist for our understanding of basic radiobiological principles as have the…”
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Accelerated heavy particles and the lens. VII: The cataractogenic potential of 450 MeV/amu iron ions by Worgul, BV, Brenner, DJ, Medvedovsky, C, Merriam, GR, Jr, Huang, Y

“…PURPOSE. To determine the cataractogenic potential dose of high velocity iron ions as a fixation of dose administered singly or fractionated. The dose is…”
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Modulating radiation cataractogenesis by hormonally manipulating lenticular growth kinetics by Holsclaw, D S, Rothstein, H, Medvedovsky, C, Worgul, B V

“…There is considerable evidence that the lens epithelium is the primary site of injury leading to the development of cataracts following radiation exposure…”
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Near-Total Glutathione Depletion and Age-Specific Cataracts Induced by Buthionine Sulfoximine in Mice by Calvin, Harold I., Medvedovsky, Cecily, Worgul, Basil V.

“…The specific inhibitor of glutathione biosynthesis, L-buthionine sulfoximine (L-BSO), although relatively nontoxic in adult mice, induces severe glutathione…”
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Rapid deterioration of lens fibers in GSH-depleted mouse pups by Calvin, HI, Medvedovsky, C, David, JC, Broglio, TM, Hess, JL, Fu, SC, Worgul, BV

“…Lens opacities developed within 48-72 hr in mice that received a series of eight injections of L-buthionine sulfoximine, a specific inhibitor of glutathione…”
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Accelerated Heavy Particles and the Lens: III. Cataract Enhancement by Dose Fractionation by Worgul, B. V., Merriam, G. R., Medvedovsky, C., Brenner, D. J.

“…For a number of biological end points it has been shown that, in contrast to low linear energy transfer (LET) radiation, dose fractionation of high-LET…”
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Accelerated Heavy Particles and the Lens: VI. RBE Studies at Low Doses by Brenner, D. J., Medvedovsky, C., Huang, Y., Merriam, G. R., Worgul, B. V.

“…We report on the prevalence, hazard, and relative biological effectiveness (RBE) for various stages of lens opacification in rats induced by very low doses of…”
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Cortical cataract development--an expression of primary damage to the lens epithelium by Worgul, B V, Merriam, Jr, G R, Medvedovsky, C

“…Inasmuch as cortical opacities constitute the majority of senile cataracts their pathogenesis has been a matter of investigative concern for over a century…”
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Evidence of genotoxic damage in human cataractous lenses by Worgul, B V, David, J, Odrich, S, Merriam, Jr, G R, Medvedovsky, C, Merriam, J C, Trokel, S L, Geard, C R

“…Lens epithelial fragments (tags) recovered from individuals during routine cataract extraction have been assessed for cellular changes reflective of genotoxic…”
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Use of non-subjective analysis of lens transparency in experimental radiation cataract research by Worgul, B V, Medvedovsky, C, Wu, B

“…Historically the major impediment to radiation cataract follow-up has been the necessarily subjective nature of assessing the degree of lens transparency. This…”
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Stationary radiation cataracts: an animal model by Holsclaw, D S, Merriam, Jr, G R, Medvedovsky, C, Rothstein, H, Worgul, B V

“…The restitution of normal fibergenesis that occurs in stationary radiation cataracts provides a unique opportunity to study the cytopathomechanism of…”
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Accelerated heavy ions and the lens. IX. Late effects of LET and dose on cellular parameters in the murine lens by Tao, F, Medvedovsky, C, David, J, Broglio, T, Powers-Risius, P, Alpen, E L, Worgul, B V

“…Lenses of mice irradiated with 250 MeV protons, 670 MeV/amu 20Ne, 600 MeV/amu 56Fe, 350 MeV/amu 56Fe, 600 MeV/amu 93Nb or 593 MeV/amu 139La ions were evaluated…”
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The effects of ionizing radiation on the dividing cells of the conjunctival epithelium by Mitrani, R, Worgul, B V

“…The influence of an X-ray dose of 10 Gy (1000 rads) on mitosis in the rat conjunctival epithelium was assessed. A mitotic inhibition began 1 hour…”
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