Search Results - "Wootton, Daniel"

Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study by Turtle, Lance, Thorpe, Mathew, Drake, Thomas M, Swets, Maaike, Palmieri, Carlo, Russell, Clark D, Ho, Antonia, Aston, Stephen, Wootton, Daniel G, Richter, Alex, de Silva, Thushan I, Hardwick, Hayley E, Leeming, Gary, Law, Andy, Openshaw, Peter J M, Harrison, Ewen M, Baillie, J Kenneth, Semple, Malcolm G, Docherty, Annemarie B

“…Immunocompromised patients may be at higher risk of mortality if hospitalised with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients…”
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Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA by Bradley, Patrick, Frost, Freddy, Tharmaratnam, Kukatharmini, Wootton, Daniel G

“…IntroductionThe COVID-19 pandemic is ongoing, yet, due to the lack of a COVID-19-specific tool, clinicians must use pre-existing illness severity scores for…”
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Community‐acquired pneumonia due to drug‐resistant Enterobacteriaceae: A global perspective by Aston, Stephen J., Wootton, Daniel G.

“…See related Article See related Article…”
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Household air pollution causes dose-dependent inflammation and altered phagocytosis in human macrophages by Rylance, Jamie, Fullerton, Duncan G, Scriven, James, Aljurayyan, Abdullah N, Mzinza, David, Barrett, Steve, Wright, Adam K A, Wootton, Daniel G, Glennie, Sarah J, Baple, Katy, Knott, Amy, Mortimer, Kevin, Russell, David G, Heyderman, Robert S, Gordon, Stephen B

“…Three billion people are exposed to household air pollution from biomass fuel use. Exposure is associated with higher incidence of pneumonia, and possibly…”
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Histoplasma Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen by Cornell, Tessa R, Jobe, Dawda, Donkor, Simon, Wootton, Daniel G, Pinchbeck, Gina, Sutherland, Jayne S, Scantlebury, Claire Elizabeth

“…Abstract Background Inclusion of Histoplasma in the World Health Organization's first Fungal Priority Pathogens List under “high-priority” fungal species…”
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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy by Taruc, Kyle, Yin, Charles, Wootton, Daniel G, Heit, Bryan

“…Studying the regulation of efferocytosis requires methods that are able to accurately quantify the uptake of apoptotic cells and to probe the signaling and…”
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A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days by Wootton, Daniel G, Dickinson, Laura, Pertinez, Henry, Court, Joanne, Eneje, Odiri, Keogan, Lynne, Macfarlane, Laura, Wilks, Sarah, Gallagher, Jane, Woodhead, Mark, Gordon, Stephen B, Diggle, Peter J

“…Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from…”
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Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins by Wootton, Daniel G, Diggle, Peter J, Court, Joanne, Eneje, Odiri, Keogan, Lynne, Macfarlane, Laura, Wilks, Sarah, Woodhead, Mark, Gordon, Stephen B

“…Efferocytosis (the phagocytosis of apoptotic self cells) is a key mechanism in the resolution of inflammatory processes such as community-acquired pneumonia…”
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A Haemophilus sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease by Wootton, Daniel G., Cox, Michael J., Gloor, Gregory B., Litt, David, Hoschler, Katja, German, Esther, Court, Joanne, Eneje, Odiri, Keogan, Lynne, Macfarlane, Laura, Wilks, Sarah, Diggle, Peter J., Woodhead, Mark, Moffatt, Miriam F., Cookson, William O. C., Gordon, Stephen B.

“…The demographics and comorbidities of patients with community acquired pneumonia (CAP) vary enormously but stratified treatment is difficult because…”
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Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens by Moore, Shona C, Kronsteiner, Barbara, Longet, Stephanie, Adele, Sandra, Deeks, Alexandra S, Liu, Chang, Dejnirattisai, Wanwisa, Reyes, Laura Silva, Meardon, Naomi, Faustini, Sian, Al-Taei, Saly, Tipton, Tom, Hering, Luisa M, Angyal, Adrienn, Brown, Rebecca, Nicols, Alexander R, Dobson, Susan L, Supasa, Piyada, Tuekprakhon, Aekkachai, Cross, Andrew, Tyerman, Jessica K, Hornsby, Hailey, Grouneva, Irina, Plowright, Megan, Zhang, Peijun, Newman, Thomas A H, Nell, Jeremy M, Abraham, Priyanka, Ali, Mohammad, Malone, Tom, Neale, Isabel, Phillips, Eloise, Wilson, Joseph D, Murray, Sam M, Zewdie, Martha, Shields, Adrian, Horner, Emily C, Booth, Lucy H, Stafford, Lizzie, Bibi, Sagida, Wootton, Daniel G, Mentzer, Alexander J, Conlon, Christopher P, Jeffery, Katie, Matthews, Philippa C, Pollard, Andrew J, Brown, Anthony, Rowland-Jones, Sarah L, Mongkolsapaya, Juthathip, Payne, Rebecca P, Dold, Christina, Lambe, Teresa, Thaventhiran, James E D, Screaton, Gavin, Barnes, Eleanor, Hopkins, Susan, Hall, Victoria, Duncan, Christopher J A, Richter, Alex, Carroll, Miles, de Silva, Thushan I, Klenerman, Paul, Dunachie, Susanna, Turtle, Lance

“…Both infection and vaccination, alone or in combination, generate antibody and T cell responses against severe acute respiratory syndrome coronavirus 2…”
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Bronchoalveolar lavage (BAL) for research; obtaining adequate sample yield by Collins, Andrea M, Rylance, Jamie, Wootton, Daniel G, Wright, Angela D, Wright, Adam K A, Fullerton, Duncan G, Gordon, Stephen B

“…We describe a research technique for fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) using manual hand held suction in order to remove nonadherent…”
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Feasibility study for early supported discharge in adults with respiratory infection in the UK by Collins, Andrea M, Eneje, Odiri J, Hancock, Carole A, Wootton, Daniel G, Gordon, Stephen B

“…Many patients with pneumonia and lower respiratory tract infection that could be treated as outpatients according to their clinical severity score, are in fact…”
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Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria by Wootton, Daniel G, Opara, Hyginus, Biagini, Giancarlo A, Kanjala, Maxwell K, Duparc, Stephan, Kirby, Paula L, Woessner, Mary, Neate, Colin, Nyirenda, Maggie, Blencowe, Hannah, Dube-Mbeye, Queen, Kanyok, Thomas, Ward, Stephen, Molyneux, Malcolm, Dunyo, Sam, Winstanley, Peter A

“…The objective of this study was to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil-dapsone…”
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Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria by Miller, Ann K, Bandyopadhyay, Nibedita, Wootton, Daniel G, Duparc, Stephan, Kirby, Paula L, Winstanley, Peter A, Ward, Stephen A

“…Objective Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria. The…”
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Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine by Payne, Rebecca P., Austin, James A., Skelly, Donal T., Meardon, Naomi, Faustini, Sian, Al-Taei, Saly, Moore, Shona C., Hering, Luisa M., Angyal, Adrienn, Brown, Rebecca, Nicols, Alexander R., Gillson, Natalie, Dobson, Susan L., Amini, Ali, Supasa, Piyada, Cross, Andrew, Bridges-Webb, Alice, Linder, Aline, Altmann, Thomas, Whitham, Rachel, Phillips, Eloise, Hargreaves, Alexander, Shields, Adrian, Foulkes, Sarah, Johnson, Sile, Wootton, Daniel G., Conlon, Christopher P., Matthews, Philippa C., Frater, John, Deeks, Alexandra S., Pollard, Andrew J., Brown, Anthony, Rowland-Jones, Sarah L., Mongkolsapaya, Juthathip, Hopkins, Susan, Dold, Christina, Richter, Alex, Carroll, Miles, Screaton, Gavin, de Silva, Thushan I., Turtle, Lance, Klenerman, Paul, Dunachie, Susanna, Abuelgasim, Hibatullah, Adland, Emily, Adlou, Syed, Akther, Hossain Delowar, Ansari, M. Azim, Arancibia-Cárcamo, Carolina V., Bayley, Martin, Brown, Helen, Chand, Meera, Chawla, Anu, Chinnakannan, Senthil, Cutteridge, Joseph, de Lara, Catherine, Denly, Lucy, Diffey, Ben, Dimitriadis, Stavros, Drake, Thomas M., Donnison, Timothy, Dupont, Maeva, Gardiner, Siobhan, Gilbert-Jarmillo, Javier, Goulder, Philip, Hackstein, Carl-Philipp, Hambleton, Sophie, Haniffa, Muzlifah, Haworth, Jenny, Holmes, Jennifer, Jämsén, Anni, Johnson, Sile, Jones, Chris, Kelly, Sinead, Kirk, Rosemary, Knight, Michael L., Lawrie, Allan, Lee, Lian, Lett, Lauren, Lim, Nicholas, Mentzer, Alexander J., O’Donnell, Denise, Payne, Brendan A.I., Provine, Nicholas, Robinson, Nichola, Romaniuk, Leigh, Simmons, Beatrice, Spegarova, Jarmila S., Stephenson, Emily, Subramaniam, Kris, Travis, Simon, Tucker, Stephanie, Watson, Adam, Watson, Lisa, Weeks, Esme, Wilson, Robert, Wood, Steven, Wright, Rachel, Xiao, Huiyuan, Zawia, Amira A.T.

“…Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a…”
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SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease by Barnes, Eleanor, Goodyear, Carl S., Willicombe, Michelle, Gaskell, Charlotte, Siebert, Stefan, I de Silva, Thushan, Murray, Sam M., Rea, Daniel, Snowden, John A., Carroll, Miles, Pirrie, Sarah, Bowden, Sarah J., Dunachie, Susanna J., Richter, Alex, Lim, Zixiang, Satsangi, Jack, Cook, Gordon, Pope, Ann, Hughes, Ana, Harrison, Molly, Lim, Sean H., Miller, Paul, Klenerman, Paul, Basu, Neil, Gilmour, Ashley, Irwin, Sophie, Meacham, Georgina, Marjot, Thomas, Dimitriadis, Stavros, Kelleher, Peter, Prendecki, Maria, Clarke, Candice, Mortimer, Paige, McIntyre, Stacey, Selby, Rachael, Meardon, Naomi, Nguyen, Dung, Tipton, Tom, Longet, Stephanie, Laidlaw, Stephen, Orchard, Kim, Ireland, Georgina, Thomas, David, Kearns, Pamela, Kirkham, Amanda, McInnes, Iain B.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying…”
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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy by Taruc, Kyle, Yin, Charles, Wootton, Daniel G., Heit, Bryan

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A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10days by Wootton, Daniel G, Dickinson, Laura, Pertinez, Henry, Court, Joanne, Eneje, Odiri, Keogan, Lynne, Macfarlane, Laura, Wilks, Sarah, Gallagher, Jane, Woodhead, Mark, Gordon, Stephen B, Diggle, Peter J

“…Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from…”
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Recovery from community acquired pneumonia by Wootton, Daniel

“…Aims: To measure symptomatic recovery over a year among an adult cohort recruited from hospital with community acquired pneumonia (CAP). To measure the host…”
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Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield by Collins, Andrea M., Rylance, Jamie, Wootton, Daniel G., Wright, Angela D., Wright, Adam K. A., Fullerton, Duncan G., Gordon, Stephen B.

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