Search Results - "Wooten, Marie W."

Isolation and culture of hippocampal neurons from prenatal mice by Seibenhener, Michael L, Wooten, Marie W

“…Primary cultures of rat and murine hippocampal neurons are widely used to reveal cellular mechanisms in neurobiology. By isolating and growing individual…”
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SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity by Yan, Jin, Seibenhener, Michael Lamar, Calderilla-Barbosa, Luis, Diaz-Meco, Maria-Theresa, Moscat, Jorge, Jiang, Jianxiong, Wooten, Marie W, Wooten, Michael C

“…Protein aggregates can form in the cytoplasm of the cell and are accumulated at aggresomes localized to the microtubule organizing center (MTOC) where they are…”
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Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation by Babu, Jeganathan Ramesh, Geetha, Thangiah, Wooten, Marie W.

“…Inclusions isolated from several neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by ubiquitin‐positive proteinaceous…”
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Lysine 63 Polyubiquitination of the Nerve Growth Factor Receptor TrkA Directs Internalization and Signaling by Geetha, Thangiah, Jiang, Jianxiong, Wooten, Marie W.

“…Nerve growth factor (NGF) binding to p75 NTR influences TrkA signaling, yet the molecular mechanism is unknown. We observe that NGF stimulates TrkA…”
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Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism by Gal, Jozsef, Ström, Anna-Lena, Kwinter, David M, Kilty, Renée, Zhang, Jiayu, Shi, Ping, Fu, Weisi, Wooten, Marie W, Zhu, Haining

“…The p62/sequestosome 1 protein has been identified as a component of pathological protein inclusions in neurodegenerative diseases including amyotrophic…”
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Sequestosome 1/p62 – More than just a scaffold by Seibenhener, M. Lamar, Geetha, Thangiah, Wooten, Marie W.

“…The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing…”
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Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease by Du, Yifeng, Wooten, Michael C., Gearing, Marla, Wooten, Marie W.

“…The absence of the p62 gene in mouse brain leads to biochemical and cognitive deficits that resemble Alzheimer disease (AD). In this context, the objective of…”
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Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation by Seibenhener, M. Lamar, Babu, Jeganathan Ramesh, Geetha, Thangiah, Wong, Hing C., Krishna, N. Rama, Wooten, Marie W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease by Du, Yifeng, Wooten, Michael C, Wooten, Marie W

“…Abstract Recently we reported that declined SQSTM1/p62 expression in Alzheimer disease brain was age-correlated with oxidative damage to the p62 promoter. The…”
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Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins by Wooten, Marie W., Geetha, Thangiah, Babu, J. Ramesh, Seibenhener, M. Lamar, Peng, Junmin, Cox, Nancy, Diaz-Meco, Maria-T., Moscat, Jorge

“…Sequestosome 1 (SQSTM1)/p62 is an interacting partner of the atypical protein kinase C ζ/ι and serves as a scaffold for cell signaling and ubiquitin binding,…”
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Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration by Ramesh Babu, J, Lamar Seibenhener, M, Peng, Junmin, Strom, Anna-Lena, Kemppainen, Robert, Cox, Nancy, Zhu, Haining, Wooten, Michael C, Diaz-Meco, María T, Moscat, Jorge, Wooten, Marie W

“…The signaling adapter p62 plays a coordinating role in mediating phosphorylation and ubiquitin-dependent trafficking of interacting proteins. However, there is…”
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TrkA Receptor Endolysosomal Degradation is Both Ubiquitin and Proteasome Dependent by Geetha, Thangiah, Wooten, Marie W

“…Gaps in our knowledge exist regarding the degradation of the tropomyosin-regulated kinase A (TrkA) receptor after addition of neurotrophin, nerve growth factor…”
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Structure and functional properties of the ubiquitin binding protein p62 by Geetha, Thangiah, Wooten, Marie W.

“…Several highly conserved p62 homologs have recently been isolated, e.g. the rat atypical protein kinase C-interacting protein (ZIP), the murine A170/signal…”
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Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons by Zhou, Xiang, Babu, J. Ramesh, da Silva, Susana, Shu, Qing, Graef, Isabella A, Oliver, Tim, Tomoda, Toshifumi, Tani, Tomomi, Wooten, Marie W, Wang, Fan

“…The molecular mechanism and significance of endocytic processes involved in directional axon elongation are not well understood. The Unc-51 family of…”
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Behavioral effects of SQSTM1/p62 overexpression in mice: Support for a mitochondrial role in depression and anxiety by Seibenhener, M. Lamar, Zhao, Ting, Du, Yifeng, Calderilla-Barbosa, Luis, Yan, Jin, Jiang, Jianxiong, Wooten, Marie W., Wooten, Michael C.

“…•p62 overexpression increases the functionality of mitochondria in the hippocampus.•p62 overexpression changes behavior patterns related to affective spectrum…”
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Identification of a consensus site for TRAF6/p62 polyubiquitination by Jadhav, Trafina, Geetha, Thangiah, Jiang, Jianxiong, Wooten, Marie W.

“…Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an ubiquitin ligase that regulates a diverse array of physiological processes via forming Lys-63…”
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AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62 by Jiang, Jianxiong, Parameshwaran, Kodeeswaran, Seibenhener, M. Lamar, Kang, Myoung-Goo, Suppiramaniam, Vishnu, Huganir, Richard L., Diaz-Meco, Maria T., Wooten, Marie W.

“…SQSTM1/p62 is a multidomain/scaffold for the atypical protein kinase Cs (aPKC). Phosphorylation of AMPA receptors by PKC has been shown to regulate their…”
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Posttranslational Modifications and Receptor-Associated Proteins in AMPA Receptor Trafficking and Synaptic Plasticity by Jiang, Jianxiong, Suppiramaniam, Vishnu, Wooten, Marie W.

“…AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission in the mammalian brain. It is widely believed that the long-lasting,…”
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Association of the Atypical Protein Kinase C-interacting Protein p62/ZIP with Nerve Growth Factor Receptor TrkA Regulates Receptor Trafficking and Erk5 Signaling by Geetha, Thangiah, Wooten, Marie W

“…Previous work demonstrated an essential role for the atypical protein kinase C interacting protein, p62, in neurotrophin survival and differentiation…”
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Signal integration and diversification through the p62 scaffold protein by Moscat, Jorge, Diaz-Meco, María T., Wooten, Marie W.

“…Signal specificity of multifunctional enzymes is achieved through protein–protein interactions involving specific domains on scaffold proteins. p62 (also known…”
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