Search Results - "Wooten, MW"

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation by Babu, Jeganathan Ramesh, Geetha, Thangiah, Wooten, Marie W.

“…Inclusions isolated from several neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by ubiquitin‐positive proteinaceous…”
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Lysine 63 Polyubiquitination of the Nerve Growth Factor Receptor TrkA Directs Internalization and Signaling by Geetha, Thangiah, Jiang, Jianxiong, Wooten, Marie W.

“…Nerve growth factor (NGF) binding to p75 NTR influences TrkA signaling, yet the molecular mechanism is unknown. We observe that NGF stimulates TrkA…”
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Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation by Seibenhener, M. Lamar, Babu, Jeganathan Ramesh, Geetha, Thangiah, Wong, Hing C., Krishna, N. Rama, Wooten, Marie W.

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Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex by Moscat, J, Diaz-Meco, M T, Wooten, M W

“…The recent identification of a novel protein–protein interaction module, termed PB1, in critical signaling molecules such as p62 (also known as sequestosome1),…”
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Structure and functional properties of the ubiquitin binding protein p62 by Geetha, Thangiah, Wooten, Marie W.

“…Several highly conserved p62 homologs have recently been isolated, e.g. the rat atypical protein kinase C-interacting protein (ZIP), the murine A170/signal…”
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The p62 Scaffold Regulates Nerve Growth Factor-induced NF-κB Activation by Influencing TRAF6 Polyubiquitination by Wooten, Marie W., Geetha, Thangiah, Seibenhener, M. Lamar, Babu, J. Ramesh, Diaz-Meco, Maria T., Moscat, Jorge

“…Sequestosome 1/p62 is a scaffolding protein with several interaction modules that include a PB1 dimerization domain, a TRAF6 (tumor necrosis factor…”
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TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor by Geetha, Thangiah, Kenchappa, Rajappa S, Wooten, Marie W, Carter, Bruce D

“…TRAF6 is an E3 ubiquitin ligase that mediates signaling from members of the tumor necrosis factor and Toll‐like receptor superfamilies, including the p75…”
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Function for NF-kB in neuronal survival: Regulation by atypical protein kinase C by Wooten, Marie W.

“…Activation of the transcription factor nuclear factor kappa B (NF‐kB) has been intensely studied in the past several years due to its role as an inducible…”
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Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation? by Mamidipudi, Vidya, Wooten, Marie W

“…Several recent reports support a dual role of p75(NTR) in cell death, as well as survival, depending on the physiological or developmental stage of the cells…”
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The Atypical Protein Kinase C-interacting Protein p62 Is a Scaffold for NF-κB Activation by Nerve Growth Factor by Wooten, Marie W., Seibenhener, M.Lamar, Mamidipudi, Vidya, Diaz-Meco, Maria T., Barker, Philip A., Moscat, Jorge

“…Nerve growth factor (NGF) binding to both p75 and TrkA neurotrophin receptors activates the transcription factor nuclear factor κB (NF-κB). Here we show that…”
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Evidence for p62 aggregate formation: Role in cell survival by Paine, Michael G., Ramesh Babu, J., Seibenhener, M. Lamar, Wooten, Marie W.

“…The polyubiquitin-binding protein p62 has been shown to localize in aggregates common to several types of diseases. Here, we report that p62 forms independent…”
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Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation of Nuclear Factor-κB by Mamidipudi, Vidya, Li, Xiaoxia, Wooten, Marie W.

“…The neurotrophin nerve growth factor (NGF) supports neuronal survival by activating the transcription factor nuclear factor-κB (NF-κB). We report here, for the…”
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Association of the Atypical Protein Kinase C-interacting Protein p62/ZIP with Nerve Growth Factor Receptor TrkA Regulates Receptor Trafficking and Erk5 Signaling by Geetha, Thangiah, Wooten, Marie W

“…Previous work demonstrated an essential role for the atypical protein kinase C interacting protein, p62, in neurotrophin survival and differentiation…”
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Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells by Zhou, G, Seibenhener, M L, Wooten, M W

“…We have previously shown that protein kinase C (PKC)-zeta is activated and required for nerve growth factor (NGF)-induced differentiation of rat…”
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Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival by Wang, YongMing, Seibenhener, M. Lamar, Vandenplas, Michel L., Wooten, Marie W.

“…Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations…”
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Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway by Wooten, Marie W., Vandenplas, Michel L., Seibenhener, M. Lamar, Geetha, Thangiah, Diaz-Meco, Maria T.

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Mapping of Atypical Protein Kinase C within the Nerve Growth Factor Signaling Cascade: Relationship to Differentiation and Survival of PC12 Cells by Wooten, Marie W., Seibenhener, M. Lamar, Neidigh, Kimberly B. W., Vandenplas, Michel L.

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Regulation of Interleukin Receptor-associated Kinase (IRAK) Phosphorylation and Signaling by Iota Protein Kinase C by Mamidipudi, Vidya, Lin, Chunru, Seibenhener, M. Lamar, Wooten, Marie W.

“…We have previously shown that the activity of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) is required for nerve growth factor (NGF)-induced…”
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Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: Evidence for regulation of nerve growth factor-induced differentiation by Samuels, Ivy S., Seibenhener, M. Lamar, Neidigh, Kimberly B.W., Wooten, Marie W.

“…Atypical protein kinase Cs zeta and lambda/iota play a functional role in the regulation of NGF‐induced differentiation and survival of pheochromocytoma, PC12…”
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Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C by White, Wendy O., Seibenhener, M. Lamar, Wooten, Marie W.

“…Herein, we employed a combined approach of molecular modeling and site‐directed mutagenesis to address the role of tyrosine phosphorylation in transport of…”
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