Search Results - "Woolverton, W L"

Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs by Wee, S, Anderson, K G, Baumann, M H, Rothman, R B, Blough, B E, Woolverton, W L

“…It has been reported that among drugs with mixed actions on central nervous system monoamine systems, increased serotonergic activity is associated with…”
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Self-administration of cocaine–remifentanil mixtures by monkeys: an isobolographic analysis by Woolverton, W. L., Wang, Zhixia, Vasterling, Theresa, Tallarida, Ronald

“…Rationale Abuse of mixtures of stimulants and opioids (“speedball”) is common. Although this combination has been studied in the laboratory, conclusions about…”
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5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques by Bogdan, R., Fitzgibbon, H., Woolverton, W.L., Bethea, C.L., Iyo, A.H., Stockmeier, C.A., Kyle, P.B., Austin, M.C.

“…► rh5-HTTLPR short allele carriers had reduced cortical TREK1 protein expression. ► Female monkeys had reduced cortical TREK1 protein expression. ► Chronic…”
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Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys by Fantegrossi, W.E., Winger, G., Woods, J.H., Woolverton, W.L., Coop, A.

“…1-Benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)piperazine (TFMPP) are two designer drugs that are often sold in combination tablets via the internet…”
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Self-administration of drug mixtures by monkeys: combining drugs with comparable mechanisms of action by Woolverton, W.L., Wang, Zhixia, Vasterling, Theresa, Carroll, F. Ivy, Tallarida, Ronald

“…Rationale Abuse of drug mixtures is common. Drug interactions that are super-additive in terms of reinforcing effects may contribute to this phenomenon…”
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Self-administration of cocaine-pentobarbital mixtures by rhesus monkeys by Woolverton, W.L, Wang, Zhixia

“…Abstract A number of experiments have evaluated self-administration of the combination of a stimulant and an opioid. Less is known about the combination of a…”
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The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys by Weed, M R, Woolverton, W L

“…Central dopaminergic systems have been implicated in the reinforcing effects of a number of stimuli, including drugs of abuse; however, the role of dopamine D1…”
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Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms by Woolverton, W L, Ranaldi, R, Wang, Z, Ordway, G A, Paul, I A, Petukhov, P, Kozikowski, A

“…Drugs that block dopamine uptake often function as positive reinforcers but can differ along the dimension of strength or effectiveness as a positive…”
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Neurobiology of cocaine abuse by Woolverton, W L, Johnson, K M

“…The recent escalation of cocaine abuse has increased awareness of the need to understand the behavioral effects of cocaine and the determinants of those…”
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Self-administration of cocaine and heroin combinations by rhesus monkeys responding under a progressive-ratio schedule by ROWLETT, J. K, WOOLVERTON, W. L

“…The present study examined the reinforcing effects of cocaine and heroin, alone and combined, in rhesus monkeys (n = 4) responding under a progressive-ratio…”
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Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys by Kleven, M S, Anthony, E W, Woolverton, W L

“…Rhesus monkeys (n = 6), trained in a two-lever, food-reinforced paradigm to discriminate cocaine (0.2 or 0.4 mg/kg, i.m.) from saline, received injections of…”
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3' and 4'-chloro-substituted analogs of benztropine : intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys by WOOLVERTON, W. L, ROWLETT, J. K, WILCOX, K. M, PAUL, I. A, KLINE, R. H, NEWMAN, A. H, KATZ, J. L

“…The reinforcing effects of many psychomotor stimulants have been related to increased dopaminergic neurotransmission. Drugs that block dopamine (DA) uptake…”
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Choice under concurrent VI schedules : comparison of behavior maintained by cocaine or food by WOOLVERTON, W. L, ALLING, K

“…Previous research has shown that concurrent schedule responding maintained by cocaine under short variable-interval (VI) schedules is well described by the…”
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Comparison of the reinforcing efficacy of cocaine and procaine in rhesus monkeys responding under a progressive-ratio schedule by WOOLVERTON, W. L

“…Rhesus monkeys (n = 5) were prepared with chronic IV catheters and trained to lever press under a PR schedule of drug injection. The schedule consisted of five…”
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Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain by Commins, D L, Vosmer, G, Virus, R M, Woolverton, W L, Schuster, C R, Seiden, L S

“…(+/-)-3,4-Methylenedioxymethylamphetamine (MDMA) was administered s.c. to rats (10, 20 or 40 mg/kg b. wt.) and guinea pigs (20 mg/kg) twice a day for 4 days, 2…”
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Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys by WOOLVERTON, William L, HECHT, Gerald S, AGOSTON, Gregory E, KATZ, Jonathan L, NEWMAN, Amy Hauck

“…Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate…”
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On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns by Wilcox, K M, Rowlett, J K, Paul, I A, Ordway, G A, Woolverton, W L

“…Drugs that are self-administered appear to vary in their potency and effectiveness as positive reinforcers. Understanding mechanisms that determine relative…”
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Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys by ROWLETT, J. K, WINGER, G, CARTER, R. B, WOOD, P. L, WOODS, J. H, WOOLVERTON, W. L

“…The present study was designed to assess possible abuse-related effects of the endogenous neuroactive steroid pregnanolone…”
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Effects of increasing the magnitude of an alternative reinforcer on drug choice in a discrete-trials choice procedure by NADER, M. A, WOOLVERTON, W. L

“…Rhesus monkeys were trained in a discrete-trials choice procedure and allowed to choose between food delivery (1-16 pellets; 1 g/pellet) and intravenous…”
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Intravenous self-administration of cocaine under concurrent VI schedules of reinforcement by WOOLVERTON, W. L

“…Under concurrent VI (conc VI) schedules of reinforcement, organisms match the proportion of responses to the proportion of reinforcers obtained from the…”
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