Search Results - "Woolley, Marie L."

D1 -like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia by McLean, Samantha L, Idris, Nagi F, Woolley, Marie L, Neill, Joanna C

“…Abstract Phencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D1…”
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Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice by WOOLLEY, Marie L, CARTER, Helen J, GARTLON, Jane E, WATSON, Jeanette M, DAWSON, Lee A

“…The muscarinic acetylcholine receptor (mAChR) agonist, xanomeline, attenuates amphetamine-induced activity in WT mice. This effect is abolished in mice lacking…”
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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790 by WOOLLEY, Marie L, MARSDEN, Charles A, SLEIGHT, Andrew J, FONE, Kevin C. F

“…Accumulating evidence suggests a potential role for the 5-HT(6 )receptor in cognitive function and the potential use of 5-HT(6) receptor antagonists in the…”
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Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat by McLean, Samantha L., Woolley, Marie L., Thomas, Dave, Neill, Joanna C.

“…Rationale 5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. Aim The aim of this study was to investigate the…”
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GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models by Medhurst, Andrew D, Atkins, Alan R, Beresford, Isabel J, Brackenborough, Kim, Briggs, Michael A, Calver, Andrew R, Cilia, Jackie, Cluderay, Jane E, Crook, Barry, Davis, John B, Davis, Rebecca K, Davis, Robert P, Dawson, Lee A, Foley, Andrew G, Gartlon, Jane, Gonzalez, M Isabel, Heslop, Teresa, Hirst, Warren D, Jennings, Carol, Jones, Declan N C, Lacroix, Laurent P, Martyn, Abbe, Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M, Roberts, Jennifer C, Schogger, Joanne, Southam, Eric, Stean, Tania O, Trail, Brenda K, Upton, Neil, Wadsworth, Graham, Wald, Jeffrey A, White, Trevor, Witherington, Jason, Woolley, Marie L, Worby, Angela, Wilson, David M

“…6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel histamine H(3) receptor…”
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Pharmacological characterization of N‐[(2S)‐5‐(6‐fluoro‐3‐pyridinyl)‐2, 3‐dihydro‐1H‐inden‐2‐yl]‐2‐propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator by Ward, Simon E, Beswick, Paul, Calcinaghi, Novella, Dawson, Lee A, Gartlon, Jane, Graziani, Francesca, Jones, Declan N C, Lacroix, Laurent, Selina Mok, M H, Oliosi, Beatrice, Pardoe, Joanne, Starr, Kathryn, Woolley, Marie L, Harries, Mark H

“…Background and Purpose AMPA receptor positive allosteric modulators represent a potential therapeutic strategy to improve cognition in people with…”
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A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats by McLean, Samantha L., Beck, Jonathan P., Woolley, Marie L., Neill, Joanna C.

“…The NMDA receptor antagonist, phencyclidine (PCP), has been shown to induce symptoms characteristic of schizophrenia. A loss in executive function and the…”
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Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro : Stereospecificity and selectivity profiles by BLEAKMAN, D, BALLYK, B. A, LODGE, D, SCHOEPP, D. D, PALMER, A. J, BATH, C. P, SHARPE, E. F, WOOLLEY, M. L, BUFTON, H. R, KAMBOJ, R. K, TARNAWA, I

“…The activity and selectivity of the glutamate receptor antagonists belonging to the 2,3-benzodiazepine class of compounds have been examined at recombinant…”
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The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison by Ballard, Theresa M, Woolley, Marie L, Prinssen, Eric, Huwyler, Jörg, Porter, Richard, Spooren, Will

“…Antagonists at the metabotropic glutamate 5 (mGlu5) receptor produce robust anxiolytic effects in a number of rat tests. However, there is evidence that mGlu5…”
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Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040 by Southam, Eric, Cilia, Jackie, Gartlon, Jane E., Woolley, Marie L., Lacroix, Laurent P., Jennings, Carol A., Cluderay, Jane E., Reavill, Charlie, Rourke, Claire, Wilson, David M., Dawson, Lee A., Medhurst, Andrew D., Jones, Declan N. C.

“…Objectives To test the novel nonimidazole histamine H 3 receptor antagonist 5-[(3-cyclobutyl-2,3,4,5-tetrahydro-1 H -3-benzazapin-7-yl)oxy]- N…”
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Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat by Woolley, Marie L, Waters, Kerry A, Reavill, Charlie, Bull, Sharlene, Lacroix, Laurent P, Martyn, Abbe J, Hutcheson, Daniel M, Valerio, Enzo, Bate, Simon, Jones, Declan N.C, Dawson, Lee A

“…Current therapies for attention deficit hyperactivity disorder comprise psychostimulants, which block the dopamine transporter and/or stimulate the release of…”
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TIME-DEPENDENT CHANGES IN GAMMA OSCILLATIONS AND PARVALBUMIN IMMUNOREACTIVE CELL DENSITY IN THE CA2/3 REGION OF THE RAT HIPPOCAMPUS FOLLOWING SUB-CHRONIC PHENCYCLIDINE TREATMENT by McLean, Samantha L, Harte, Mike K, Marsh, Samuel, Jones, Gareth A, Davies, Ceri, Woolley, Marie L, Neill, Jo C

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Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M 4 receptor knockout mice and attenuated in muscarinic M 1 receptor knockout mice by Woolley, Marie L., Carter, Helen J., Gartlon, Jane E., Watson, Jeanette M., Dawson, Lee A.

“…The muscarinic acetylcholine receptor (mAChR) agonist, xanomeline, attenuates amphetamine-induced activity in WT mice. This effect is abolished in mice lacking…”
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5-ht6 receptors by Woolley, Marie L, Marsden, Charles A, Fone, Kevin C F

“…The 5-hydroxytryptamine(6) (5-ht(6)) was one of the most recent additions to the 5-HT receptor family, selective antagonists have recently been developed and…”
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D 1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia by McLean, Samantha L., Idris, Nagi F., Woolley, Marie L., Neill, Joanna C.

“…Phencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D 1-like…”
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Potential of 5-HT6 Antagonists for the Treatment of Cognitive Disorders by R. Schreiber, Marie L. Woolley

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Rapid Communication: Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice by Woolley, Marie L, Carter, Helen J, Gartlon, Jane E, Watson, Jeanette M, Dawson, Lee A

“…The muscarinic acetylcholine receptor (mAChR) agonist, xanomeline, attenuates amphetamine-induced activity in WT mice. This effect is abolished in mice lacking…”
Get full text

D sub(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia by McLean, Samantha L, Idris, Nagi F, Woolley, Marie L, Neill, Joanna C

“…Phencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D sub(1)-like…”
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The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition : a comparison: Glutamate Receptor Subtypes: Promising New Pharmacotherapeutic Targets by BALLARD, Theresa M, WOOLLEY, Marie L, PRINSSEN, Eric, HUWYLER, Jorg, PORTER, Richard, SPOOREN, Will

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D(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia by McLean, Samantha L, Idris, Nagi F, Woolley, Marie L, Neill, Joanna C

“…Phencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D(1)-like…”
Get full text