Search Results - "Woolfson, A D"

Design of a silicone reservoir intravaginal ring for the delivery of oxybutynin by Woolfson, A.D, Malcolm, R.K, Gallagher, R.J

“…Oxybutynin, a drug of choice in the treatment of urinary incontinence, has low oral bioavailability due to extensive first-pass metabolism. A toxic metabolite,…”
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Controlled release of a model antibacterial drug from a novel self-lubricating silicone biomaterial by Malcolm, R.K, McCullagh, S.D, Woolfson, A.D, Gorman, S.P, Jones, D.S, Cuddy, J

“…There is considerable interest in developing medical devices that provide controlled delivery of biologically active agents, for example, to reduce the…”
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Successful photodynamic therapy of vulval Paget's disease using a novel patch‐based delivery system containing 5‐aminolevulinic acid by Zawislak, A.A., McCarron, P.A., McCluggage, W.G., Price, J.H., Donnelly, R.F., McClelland, H.R., Dobbs, S.P., Woolfson, A.D.

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Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease by Jones, David S, Woolfson, A.David, Brown, Andrew F, Coulter, Wilson A, McClelland, Cathy, Irwin, Christopher R

“…This study describes the formulation, characterisation and preliminary clinical evaluation of mucoadhesive, semi-solid formulations containing…”
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Sustained Release of 5-Fluorouracil from Polymeric Nanoparticles by McCARRON, PAUL A., WOOLFSON, A. DAVID, KEATING, SIOBHÁN M.

“…The use of biodegradable nanoparticles loaded with 5‐fluorouracil was investigated as a potential means to sustain the release of this drug. Nanoparticles…”
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Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases by JONES, D. S, WOOLFSON, A. D, DJOKIC, J, COULTER, W. A

“…This study examined the mechanical characteristics and release of tetracycline from bioadhesive, semi-solid systems which were designed for the treatment of…”
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Design of an intravaginal ring for the controlled delivery of 17β-estradiol as its 3-acetate ester by Woolfson, A.D., Elliott, G.R.E., Gilligan, Claire A., Passmore, Clare M.

“…Suitable ester prodrugs of 17β-estradiol are identified, thus permitting effective sustained and controlled estrogen replacement therapy (ERT) from an…”
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Randomized trial of novel tetracaine patch to provide local anaesthesia in neonates undergoing venepuncture by Long, C.P., McCafferty, D.F., Sittlington, N.M., Halliday, H.L., Woolfson, A.D., Jones, D.S.

“…Procedures such as venepuncture or heel prick are painful and may cause considerable stress to newborn infants. Topical local anaesthetics are effective for…”
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Rheological, mechanical and membrane penetration properties of novel dual drug systems for percutaneous delivery by Woolfson, A.D, Malcolm, R.K, Campbell, K, Jones, D.S, Russell, J.A

“…In this study it has been demonstrated that mixtures of two solid drugs, ibuprofen and methyl nicotinate, with different but complementary pharmacological…”
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Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels by JONES, D. S, WOOLFSON, A. D, BROWN, A. F

“…This study examined the rheological and textural characteristics (hardness, compressibilty, adhesiveness and cohesiveness) of bioadhesive oral gels containing…”
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Drug delivery by the intravaginal route by Woolfson, A D, Malcolm, R K, Gallagher, R

“…The human vagina represents a potential, accessible space that offers a valuable route for drug delivery through the use of specifically designed carrier…”
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Mechanical Characterization and Drug Permeation Properties of Tetracaine-loaded Bioadhesive Films for Percutaneous Local Anesthesia by Moss, G. P., Gullick, D. R., Woolfson, A. D., McCafferty, D. F.

“…ABSTRACT In the development of bioadhesive patch devices for percutaneous local anesthesia, the tensile properties of the films produced after the casting of…”
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Physicochemical characterization and preliminary in vivo efficacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis by Jones, D S, Irwin, C R, Woolfson, A D, Djokic, J, Adams, V

“…In this study, the physicochemical properties and preliminary in vivo clinical performance of formulations containing hydroxyethylcellulose (HEC; 3, 5, 10%…”
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Effect of percutaneous local anaesthetics on pain reduction during pulse dye laser treatment of portwine stains by McCafferty, D F, Woolfson, A D, Handley, J, Allen, G

“…We have used EMLA, 4% amethocaine gel and placebo for facial portwine stains, for a period of 1 h, in a double-blind study. After removal of the preparations…”
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Novel bioadhesive delivery system for percutaneous local anaesthesia by McCafferty, D F, Woolfson, A D, Moss, G P

“…We have assessed the efficacy of a novel bioadhesive amethocaine patch device, compared to Ametop gel, in a randomized, double-blinded trial. Patch and gel…”
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Breaking out of the Ivory Tower: from Academia to Clinic by Woolfson, A. D.

“…This paper considers the relationship between academic research and industry in terms of the commercial exploitation of product or process driven programmes…”
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P11-12. A novel vaginal ring device for the sustained delivery of recombinant C-clade HIV-1 CN54gp140 by Morrow, RJ, Donnelly, L, Curran, RM, Malcolm, RK, Woolfson, AD, Andrews, GP, Shattock, R

“…Doc number: P157…”
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Response surface methodology as a predictive tool for determining the effects of preparation conditions on the physicochemical properties of poly(isobutylcyanoacrylate) nanoparticles by McCarron, Paul A., Woolfson, A.David, Keating, Siobhán M.

“…Preparation conditions of nanoparticles greatly influence their physicochemical characteristics. A factorial design was used to evaluate the influence of these…”
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Conditioning film and environmental effects on the adherence of Candida spp. to silicone and poly(vinylchloride) biomaterials by Jones, D S, McGovern, J G, Adair, C G, Woolfson, A D, Gorman, S P

“…The reported incidence of colonization of oropharyngeal medical devices with Candida spp. has increased in recent years, although few studies that have…”
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In Vivo ac Impedance Spectroscopy of Human Skin: Theory and Problems in Monitoring of Passive Percutaneous Drug Delivery by LACKERMEIER, A. H., McADAMS, E. T., MOSS, G. P., WOOLFSON, A. D.

“…: The use of impedance spectroscopy to evaluate transdermal drug delivery is discussed and new techniques and protocols are suggested to avoid or minimize…”
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