Search Results - "Woolford, L."

Ribosome assembly coming into focus by Klinge, Sebastian, Woolford, John L.

“…In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have identified most of the factors that participate in this complex…”
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Functions of Ribosomal Proteins in Assembly of Eukaryotic Ribosomes In Vivo by de la Cruz, Jesús, Karbstein, Katrin, Woolford, John L

“…The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in eukaryotes contain 79-80 proteins and four ribosomal RNAs (rRNAs) more…”
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Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes by Wu, Shan, Tutuncuoglu, Beril, Yan, Kaige, Brown, Hailey, Zhang, Yixiao, Tan, Dan, Gamalinda, Michael, Yuan, Yi, Li, Zhifei, Jakovljevic, Jelena, Ma, Chengying, Lei, Jianlin, Dong, Meng-Qiu, Woolford, John L., Gao, Ning

“…The cryo-electron microscopy structures of yeast nucleoplasmic pre-60S ribosomal particles give insight into the function of multiple assembly factors in…”
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Ribosome biogenesis in the yeast Saccharomyces cerevisiae by Woolford, Jr, John L, Baserga, Susan J

“…Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information in the genome to create the proteome in all cells. In yeast these…”
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Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1 by Ma, Chengying, Wu, Shan, Li, Ningning, Chen, Yan, Yan, Kaige, Li, Zhifei, Zheng, Lvqin, Lei, Jianlin, Woolford, John L, Gao, Ning

“…The cryo-EM structure of pre-60S purified via Nmd3 provides molecular insights into the roles of assembly factors Nmd3, Lsg1, Tif6 and Reh1 in the last steps…”
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Mod-seq: high-throughput sequencing for chemical probing of RNA structure by Talkish, Jason, May, Gemma, Lin, Yizhu, Woolford, Jr, John L, McManus, C Joel

“…The functions of RNA molecules are intimately linked to their ability to fold into complex secondary and tertiary structures. Thus, understanding how these…”
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Eukaryote-specific rRNA expansion segments function in ribosome biogenesis by Ramesh, Madhumitha, Woolford, Jr, John L

“…The secondary structure of ribosomal RNA (rRNA) is largely conserved across all kingdoms of life. However, eukaryotes have evolved extra blocks of rRNA…”
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Additional principles that govern the release of pre-ribosomes from the nucleolus into the nucleoplasm in yeast by LaPeruta, Amber J, Micic, Jelena, Woolford Jr, John L

“…Abstract During eukaryotic ribosome biogenesis, pre-ribosomes travel from the nucleolus, where assembly is initiated, to the nucleoplasm and then are exported…”
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A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains by Gamalinda, Michael, Ohmayer, Uli, Jakovljevic, Jelena, Kumcuoglu, Beril, Woolford, Joshua, Mbom, Bertrade, Lin, Lawrence, Woolford, Jr, John L

“…Despite having high-resolution structures for eukaryotic large ribosomal subunits, it remained unclear how these ribonucleoprotein complexes are constructed in…”
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rRNA Maturation in Yeast Cells Depleted of Large Ribosomal Subunit Proteins by Pöll, Gisela, Braun, Tobias, Jakovljevic, Jelena, Neueder, Andreas, Jakob, Steffen, Woolford, John L. Jr, Tschochner, Herbert, Milkereit, Philipp

“…The structural constituents of the large eukaryotic ribosomal subunit are 3 ribosomal RNAs, namely the 25S, 5.8S and 5S rRNA and about 46 ribosomal proteins…”
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Principles of 60S ribosomal subunit assembly emerging from recent studies in yeast by Konikkat, Salini, Woolford, Jr, John L

“…Ribosome biogenesis requires the intertwined processes of folding, modification, and processing of ribosomal RNA, together with binding of ribosomal proteins…”
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Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly by Micic, Jelena, Li, Yu, Wu, Shan, Wilson, Daniel, Tutuncuoglu, Beril, Gao, Ning, Woolford, John L.

“…The protein composition and structure of assembling 60S ribosomal subunits undergo numerous changes as pre-ribosomes transition from the nucleolus to the…”
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Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel by Wilson, Daniel M., Li, Yu, LaPeruta, Amber, Gamalinda, Michael, Gao, Ning, Woolford, John L.

“…The nascent polypeptide exit tunnel (NPET) is a major functional center of 60S ribosomal subunits. However, little is known about how the NPET is constructed…”
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Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines by Staley, Jonathan P, Woolford, John L

“…Ribosomes and spliceosomes are ribonucleoprotein nanomachines that catalyze translation of mRNA to synthesize proteins and splicing of introns from pre-mRNAs,…”
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Putting It All Together: The Roles of Ribosomal Proteins in Nucleolar Stages of 60S Ribosomal Assembly in the Yeast Saccharomyces cerevisiae by Ayers, Taylor N, Woolford, John L

“…Here we review the functions of ribosomal proteins (RPs) in the nucleolar stages of large ribosomal subunit assembly in the yeast . We summarize the effects of…”
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Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processing by Sahasranaman, Aarti, Dembowski, Jill, Strahler, John, Andrews, Philip, Maddock, Janine, Woolford Jr, John L

“…The precise functions of most of the ∼200 assembly factors and 79 ribosomal proteins required to construct yeast ribosomes in vivo remain largely unexplored…”
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Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation by Micic, Jelena, Rodríguez-Galán, Olga, Babiano, Reyes, Fitzgerald, Fiona, Fernández-Fernández, José, Zhang, Yunyang, Gao, Ning, Woolford, John L, de la Cruz, Jesús

“…During translation, nascent polypeptide chains travel from the peptidyl transferase center through the nascent polypeptide exit tunnel (NPET) to emerge from…”
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Ribosome Assembly Factors Pwp1 and Nop12 Are Important for Folding of 5.8S rRNA during Ribosome Biogenesis in Saccharomyces cerevisiae by Talkish, Jason, Campbell, Ian Winsten, Sahasranaman, Aarti, Jakovljevic, Jelena, Woolford, John L.

“…Previous work from our lab suggests that a group of interdependent assembly factors (A 3 factors) is necessary to create early, stable preribosomes. Many of…”
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Pathological Findings in Koala Retrovirus-positive Koalas (Phascolarctos cinereus) from Northern and Southern Australia by Fabijan, J., Sarker, N., Speight, N., Owen, H., Meers, J., Simmons, G., Seddon, J., Emes, R.D., Tarlinton, R., Hemmatzadeh, F., Woolford, L., Trott, D.J.

“…Koala retrovirus (KoRV) infection shows differences in prevalence and load between northern and southern Australian koala populations; however, the effect of…”
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Saccharomyces cerevisiae Ribosomal Protein L26 Is Not Essential for Ribosome Assembly and Function by Babiano, Reyes, Gamalinda, Michael, Woolford, John L., de la Cruz, Jesús

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