Search Results - "Woolf, T M"

Specificity of Antisense Oligonucleotides in Vivo by Woolf, Tod M., Melton, Douglas A., Charles G. B. Jennings

“…Antisense oligonucleotides are widely used as inhibitors of gene expression in cultured cells and have been proposed as potential therapeutic agents, but it is…”
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Therapeutic repair of mutated nucleic acid sequences by Woolf, Tod M

“…The principle of therapeutic nucleic acid repair has been demonstrated in cell-free and cell culture experiments, in which compounds bind to and repair mutated…”
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Toward the Therapeutic Editing of Mutated RNA Sequences by Woolf, Tod M., Chase, Jennifer M., Stinchcomb, Dan T.

“…If RNA editing could be rationally directed to mutated RNA sequences, genetic diseases caused by certain base substitutions could be treated. Here we use a…”
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The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos by WOOLF, T. M, JENNINGS, C. G. B, REBAGLIATI, M, MELTON, D. A

“…The properties of antisense phosphorothioate and unmodified oligodeoxynucleotides have been studied in Xenopus oocytes and embryos. We find that…”
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Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic Insult In Vitro by Miao, Ningning, Wang, Monica, Ott, Jennifer A, D'Alessandro, Josephine S, Woolf, Tod M, Bumcrot, David A, Mahanthappa, Nagesh K, Pang, Kevin

“…Sonic hedgehog (Shh), an axis-determining secreted protein, is expressed during early vertebrate embryogenesis in the notochord and ventral neural tube. In…”
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Expression of Activin mRNA during Early Development in Xenopus laevis by Dohrmann, Cord E., Hemmati-Brivanlou, Ali, Thomsen, Gerald H., Fields, Andrew, Woolf, Tod M., Melton, Douglas A.

“…Activins are members of the transforming growth factor-β superfamily, a class of peptide growth factors that can regulate the growth and differentiation of a…”
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Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb by Jarvis, T C, Wincott, F E, Alby, L J, McSwiggen, J A, Beigelman, L, Gustofson, J, DiRenzo, A, Levy, K, Arthur, M, Matulic-Adamic, J, Karpeisky, A, Gonzalez, C, Woolf, T M, Usman, N, Stinchcomb, D T

“…Expression of the proto-oncogene c-myb is necessary for proliferation of vascular smooth muscle cells. We have developed synthetic hammerhead ribozymes that…”
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Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin typesCapsule Summary by Angela L. Bosma, MD, Wouter Ouwerkerk, PhD, Madeline J. Heidema, MD, David Prieto-Merino, PhD, Michael R. Ardern-Jones, MD, PhD, Paula Beattie, MD, Sara J. Brown, MD, PhD, John R. Ingram, MD, PhD, Alan D. Irvine, MD, DSc, Graham Ogg, MD, PhD, Prakash Patel, BSc, Nick J. Reynolds, MD, PhD, R.M. Ross Hearn, MD, Mandy Wan, PhD, Richard B. Warren, MD, PhD, Richard T. Woolf, MD, PhD, Ariënna M. Hyseni, Louise A.A. Gerbens, MD, PhD, Phyllis I. Spuls, MD, PhD, Carsten Flohr, MD, PhD, Maritza A. Middelkamp-Hup, MD, PhD

“…Background: Few data exist on differences in treatment effectiveness and safety in atopic dermatitis patients of different skin types. Objective: To…”
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To cleave or not to cleave: ribozymes and antisense by Woolf, T M

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Variations on the theme of genomics. Functional genomics: from identifying proteins to faster drug discovery, Westin City Center Hotel, Washington, DC, USA, 10-11 March 1998 by Woolf, T M, Taylor, M

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Ciliated Cultures From Patients With Primary Ciliary Dyskinesia Produce Nitric Oxide in Response to Haemophilus influenzae Infection and Proinflammatory Cytokines by Walker, Woolf T., BM, Jackson, Claire L., PhD, Coles, Janice, BSc (Hons), Lackie, Peter M., PhD, Faust, Saul N., MBBS, PhD, Hall-Stoodley, Luanne, PhD, Lucas, Jane S., BM, PhD

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Variations on the theme of genomics by Woolf, Tod M, Taylor, Margaret

“…Functional Genomics: From Identifying Proteins to Faster Drug Discovery, Westin City Center Hotel, Washington DC, USA, 10–11 March 1998…”
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Why RNAi makes sense by Hough, Shelley R, Wiederholt, Kristin A, Burrier, Althea C, Woolf, Tod M, Taylor, Margaret F

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Antisense oligonucleotides as antiviral agents: prospects and problems by Cantin, E M, Woolf, T M

“…One possible strategy for the development of antiviral drugs is to synthesize short antisense oligonucleotides that interfere specifically with RNA…”
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Triple-Strand-Forming Methylphosphonate Oligodeoxynucleotides Targeted to mRNA Efficiently Block Protein Synthesis by Reynolds, Mark A., Arnold, Lyle J., Almazan, Melissa T., Beck, Terry A., Hogrefe, Richard I., Metzler, Michael D., Stoughton, Scott R., Tseng, Ben Y., Trapane, Tina L., Paul O. Ps. Ts'o, Woolf, Tod M.

“…Antisense oligonucleotides are ordinarily targeted to mRNA by double-stranded (Watson-Crick) base recognition but are seldom targeted by triple-stranded…”
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