Search Results - "Woolf, E. J."

Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma using 96-well liquid–liquid extraction and HPLC-MS/MS by Merschman, S.A., Vallano, P.T., Wenning, L.A., Matuszewski, B.K., Woolf, E.J.

“…An HPLC-MS/MS method was developed for the determination of MK-0518 (raltegravir), an HIV integrase inhibitor, in human plasma over the concentration range of…”
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Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection by Fu, I, Woolf, E.J, Matuszewski, B.K

“…The HPLC/tandem mass spectrometric (LC/MS/MS) behavior of indinavir, an HIV protease inhibitor, in human urine is presented as an example of a case where…”
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Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid chromatography with tandem mass spectrometric detection by Anderson, M.D.G., Breidinger, S.A., Woolf, E.J.

“…HPLC–MS/MS methods for the determination of a Hepatitis C NS3/NS4 protease inhibitor (MK-7009) in human plasma and Tween-treated urine were developed and…”
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Determination of fexofenadine in human plasma using 96-well solid phase extraction and HPLC with tandem mass spectrometric detection by Fu, I., Woolf, E.J., Matuszewski, B.K.

“…A fast and sensitive HPLC–MS/MS method, utilizing atmospheric pressure chemical ionization, for the determination of fexofenadine in human plasma is described…”
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Determination of risedronate in human urine by column-switching ion-pair high-performance liquid chromatography with ultraviolet detection by Vallano, P.T, Shugarts, S.B, Kline, W.F, Woolf, E.J, Matuszewski, B.K

“…An HPLC assay for the determination of risedronate in human urine was developed and validated. Risedronate and the internal standard were isolated from 5-ml…”
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Determination of dextromethorphan and its metabolite dextrorphan in human urine using high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry: a study of selectivity of a tandem mass spectrometric assay by Constanzer, M.L., Chavez-Eng, C.M., Fu, I., Woolf, E.J., Matuszewski, B.K.

“…Analytical method for the simultaneous determination of dextromethorphan ( 1) and dextrorphan ( 2) in urine, based on solid-phase extraction of drug from…”
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Elimination of autosampler carryover in a bioanalytical HPLC-MS/MS method: a case study by Vallano, P.T., Shugarts, S.B., Woolf, E.J., Matuszewski, B.K.

“…A case study in identifying and eliminating the source of autosampler carryover in a bioanalytical HPLC-MS/MS assay is described. Through a series of…”
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Improved procedure for the the determination of rofecoxib in human plasma involving 96-well solid-phase extraction and fluorescence detection by Matthews, C.Z, Woolf, E.J, Matuszewski, B.K

“…An improved assay for the determination of rofecoxib in human plasma samples is described. The analyte and an internal standard were extracted from the plasma…”
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Determination of suvorexant in human plasma using 96-well liquid–liquid extraction and HPLC with tandem mass spectrometric detection by Breidinger, S.A., Simpson, R.C., Mangin, E., Woolf, E.J.

“…•LC–MS/MS method for determination of suvorexant (MK-4305, Belsomra®) in human plasma.•The standard curve range was 1–1000ng/mL.•100μL of plasma was extracted…”
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Simultaneous determination of unlabeled and carbon-13-labeled etoricoxib, a new cyclooxygenase-2 inhibitor, in human plasma using HPLC-MS/MS by Rose, M J, Agrawal, N, Woolf, E J, Matuszewski, B K

“…A method for the simultaneous determination of etoricoxib and its carbon-13 analog ((13)C(6)-etoricoxib) from human plasma has been developed and used to…”
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Determination of an investigational HIV integrase inhibitor in human plasma using high performance liquid chromatography with tandem mass spectrometric detection by VALLANO, P. T, WOOLF, E. J, MATUSZEWSKI, B. K

“…An HPLC-MS/MS assay for the determination of an HIV integrase inhibitor,…”
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Simultaneous determination of omeprazole and 5′-hydroxyomeprazole in human plasma by liquid chromatography–tandem mass spectrometry by Woolf, E.J, Matuszewski, B.K

“…A method for the simultaneous determination of omeprazole and 5′-hydroxyomeprazole in human plasma is described. Isolation of the analytes from plasma was…”
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Determination of efavirenz, a selective non-nucleoside reverse transcriptase inhibitor, in human plasma using HPLC with post-column photochemical derivatization and fluorescence detection by Matthews, C.Z., Woolf, E.J., Mazenko, R.S., Haddix-Wiener, H., Chavez-Eng, C.M., Constanzer, M.L., Doss, G.A., Matuszewski, B.K.

“…Methods for the quantitative determination of efavirenz in human plasma and the qualitative assessment of the stereochemical integrity of efavirenz in…”
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Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans by Balani, S K, Woolf, E J, Hoagland, V L, Sturgill, M G, Deutsch, P J, Yeh, K C, Lin, J H

“…Indinavir, N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-tertiary- butylaminocarbonyl-4-(3-pyridylmethyl)piperazino]-4(S)- hydroxy-2(R)-phenylmethylpentanamide…”
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Monolithic silica liquid chromatography columns for the determination of cyclooxygenase II inhibitors in human plasma by Vallano, P.T, Mazenko, R.S, Woolf, E.J, Matuszewski, B.K

“…Methods employing monolithic HPLC columns for the determination of the cyclooxygenase II inhibitors rofecoxib ( I) and…”
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High-throughput simultaneous determination of the HIV protease inhibitors indinavir and L-756423 in human plasma using semi-automated 96-well solid phase extraction and LC–MS/MS by Rose, M.J, Merschman, S.A, Eisenhandler, R, Woolf, E.J, Yeh, K.C, Lin, L, Fang, W, Hsieh, J, Braun, M.P, Gatto, G.J, Matuszewski, B.K

“…A method for the simultaneous determination of the HIV protease inhibitors indinavir and L-756423, in human plasma has been developed. Plasma samples (0.5 ml)…”
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Simultaneous determination of unlabeled and deuterium-labeled indinavir in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection by Woolf, E J, Matuszewski, B K

“…A method for the simultaneous determination of indinavir and its hexadeuterated analog (d6-indinavir) in human plasma is described. Isolation of the analytes…”
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Dose Proportionality of Oral Etoricoxib, a Highly Selective Cyclooxygenase-2 Inhibitor, in Healthy Volunteers by Agrawal, Nancy G. B., Porras, Arturo G., Matthews, Catherine Z., Woolf, Eric J., Miller, Jutta L., Mukhopadhyay, Saurabh, Neu, Donald C., Gottesdiener, Keith M.

“…To assess dose proportionality of etoricoxib across the anticipated clinical dose range, a single panel of 12 healthy subjects was administered single oral…”
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Isolation and structural characterization of the photolysis products of etoricoxib by Matthews, C Z, Subramanian, R, Woolf, E J, Foster, N, Matuszewski, B K

“…Etoricoxib is a potent and novel selective inhibitor of cyclooxygenase-2 (COX-2) which has been developed for the treatment of osteoarthritis, rheumatoid…”
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Assessment of the in-vivo stereochemical integrity of aprepitant based on the analysis of human plasma samples via high-performance liquid chromatography with mass spectrometric detection by Kline, W. F., Woolf, E. J., Matuszewski, B. K.

“…Achiral and chiral liquid chromatographic methods utilizing mass spectrometric detection were developed to investigate the possibility of inversion of…”
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