Search Results - "Woolf, Adrian S."

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors by Bantounas, Ioannis, Ranjzad, Parisa, Tengku, Faris, Silajdžić, Edina, Forster, Duncan, Asselin, Marie-Claude, Lewis, Philip, Lennon, Rachel, Plagge, Antonius, Wang, Qi, Woolf, Adrian S., Kimber, Susan J.

“…Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney development and disease. We reproducibly differentiated three genetically…”
Get full text

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics by Rowland, Joshua, Akbarov, Artur, Eales, James, Xu, Xiaoguang, Dormer, John P, Guo, Hui, Denniff, Matthew, Jiang, Xiao, Ranjzad, Parisa, Nazgiewicz, Alicja, Prestes, Priscilla Ribeiro, Antczak, Andrzej, Szulinska, Monika, Wise, Ingrid A, Zukowska-Szczechowska, Ewa, Bogdanski, Pawel, Woolf, Adrian S, Samani, Nilesh J, Charchar, Fadi J, Tomaszewski, Maciej

“…Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We…”
Get more information

Molecular insights into genome-wide association studies of chronic kidney disease-defining traits by Xu, Xiaoguang, Eales, James M., Akbarov, Artur, Guo, Hui, Becker, Lorenz, Talavera, David, Ashraf, Fehzan, Nawaz, Jabran, Pramanik, Sanjeev, Bowes, John, Jiang, Xiao, Dormer, John, Denniff, Matthew, Antczak, Andrzej, Szulinska, Monika, Wise, Ingrid, Prestes, Priscilla R., Glyda, Maciej, Bogdanski, Pawel, Zukowska-Szczechowska, Ewa, Berzuini, Carlo, Woolf, Adrian S., Samani, Nilesh J., Charchar, Fadi J., Tomaszewski, Maciej

“…Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these…”
Get full text

Vascular growth factors play critical roles in kidney glomeruli by Gnudi, Luigi, Benedetti, Sara, Woolf, Adrian S, Long, David A

“…Kidney glomeruli ultrafilter blood to generate urine and they are dysfunctional in a variety of kidney diseases. There are two key vascular growth factor…”
Get more information

Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1 by Lopes, Carla A.M, Prosser, Suzanna L, Romio, Leila, Hirst, Robert A, O'Callaghan, Chris, Woolf, Adrian S, Fry, Andrew M

“…Ciliopathies are caused by mutations in genes encoding proteins required for cilia organization or function. We show through colocalization with PCM-1, that…”
Get full text

Predicting congenital renal tract malformation genes using machine learning by Kabir, Mitra, Stuart, Helen M., Lopes, Filipa M., Fotiou, Elisavet, Keavney, Bernard, Doig, Andrew J., Woolf, Adrian S., Hentges, Kathryn E.

“…Congenital renal tract malformations (RTMs) are the major cause of severe kidney failure in children. Studies to date have identified defined genetic causes…”
Get full text

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning by Brzóska, Hortensja Ł, d'Esposito, Angela M, Kolatsi-Joannou, Maria, Patel, Vishal, Igarashi, Peter, Lei, Yunping, Finnell, Richard H, Lythgoe, Mark F, Woolf, Adrian S, Papakrivopoulou, Eugenia, Long, David A

“…The mammalian kidney contains nephrons comprising glomeruli and tubules joined to ureteric bud-derived collecting ducts. It has a characteristic bean-like…”
Get more information

Monocyte-derived peritoneal macrophages protect C57BL/6 mice against surgery-induced adhesions by Sahputra, Rinal, Dejyong, Krittee, Woolf, Adrian S, Mack, Matthias, Allen, Judith E, Rückerl, Dominik, Herrick, Sarah E

“…Peritoneal adhesions commonly occur after abdominal or pelvic surgery. These scars join internal organs to each other or to the cavity wall and can present…”
Get full text

paradoxical teratogenic mechanism for retinoic acid by Lee, Leo M. Y, Leung, Chun-Yin, Tang, Walfred W. C, Choi, Heung-Ling, Leung, Yun-Chung, McCaffery, Peter J, Wang, Chi-Chiu, Woolf, Adrian S, Shum, Alisa S. W

“…Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian embryogenesis. Nevertheless, it has long been recognized that…”
Get full text

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation by Yates, Laura L., Papakrivopoulou, Jenny, Long, David A., Goggolidou, Paraskevi, Connolly, John O., Woolf, Adrian S., Dean, Charlotte H.

“…The planar cell polarity (PCP) pathway, incorporating non-canonical Wnt signalling, controls embryonic convergent (CE) extension, polarized cell division and…”
Get full text

Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome by Lopes, Filipa M, Grenier, Celine, Jarvis, Benjamin W, Al Mahdy, Sara, Lène-McKay, Adrian, Gurney, Alison M, Newman, William G, Waddington, Simon N, Woolf, Adrian S, Roberts, Neil A

“…Rare early-onset lower urinary tract disorders include defects of functional maturation of the bladder. Current treatments do not target the primary…”
Get full text

Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease by Jafree, Daniyal J, Moulding, Dale, Kolatsi-Joannou, Maria, Perretta Tejedor, Nuria, Price, Karen L, Milmoe, Natalie J, Walsh, Claire L, Correra, Rosa Maria, Winyard, Paul Jd, Harris, Peter C, Ruhrberg, Christiana, Walker-Samuel, Simon, Riley, Paul R, Woolf, Adrian S, Scambler, Peter J, Long, David A

“…Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing…”
Get full text

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases by Huang, Jennifer L, Woolf, Adrian S, Kolatsi-Joannou, Maria, Baluk, Peter, Sandford, Richard N, Peters, Dorien J M, McDonald, Donald M, Price, Karen L, Winyard, Paul J D, Long, David A

“…Polycystic kidney diseases (PKD) are genetic disorders characterized by progressive epithelial cyst growth leading to destruction of normally functioning renal…”
Get full text

Experimental long-term diabetes mellitus alters the transcriptome and biomechanical properties of the rat urinary bladder by Hindi, Emad A., Williams, Craig J., Zeef, Leo A. H., Lopes, Filipa M., Newman, Katie, Davey, Martha M. M., Hodson, Nigel W., Hilton, Emma N., Huang, Jennifer L., Price, Karen L., Roberts, Neil A., Long, David A., Woolf, Adrian S., Gardiner, Natalie J.

“…Diabetes mellitus (DM) is the leading cause of chronic kidney disease and diabetic nephropathy is widely studied. In contrast, the pathobiology of diabetic…”
Get full text

Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas by Tai, Guangping, Ranjzad, Parisa, Marriage, Fiona, Rehman, Samrina, Denley, Helen, Dixon, Jill, Mitchell, Karen, Day, Philip J R, Woolf, Adrian S

“…The mammalian ureter contains a water-tight epithelium surrounded by smooth muscle. Key molecules have been defined which regulate ureteric bud initiation and…”
Get full text

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization by Randles, Michael J, Woolf, Adrian S, Huang, Jennifer L, Byron, Adam, Humphries, Jonathan D, Price, Karen L, Kolatsi-Joannou, Maria, Collinson, Sophie, Denny, Thomas, Knight, David, Mironov, Aleksandr, Starborg, Toby, Korstanje, Ron, Humphries, Martin J, Long, David A, Lennon, Rachel

“…Glomerular disease often features altered histologic patterns of extracellular matrix (ECM). Despite this, the potential complexities of the glomerular ECM in…”
Get full text

Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene by Ferrante, Maria I., Romio, Leila, Castro, Silvia, Collins, John E., Goulding, David A., Stemple, Derek L., Woolf, Adrian S., Wilson, Stephen W.

“…In humans, OFD1 is mutated in oral-facial-digital type I syndrome leading to prenatal death in hemizygous males and dysmorphic faces and brain malformations,…”
Get full text

Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome by Weber, Stefanie, Thiele, Holger, Mir, Sevgi, Toliat, Mohammad Reza, Sozeri, Betül, Reutter, Heiko, Draaken, Markus, Ludwig, Michael, Altmüller, Janine, Frommolt, Peter, Stuart, Helen M., Ranjzad, Parisa, Hanley, Neil A., Jennings, Rachel, Newman, William G., Wilcox, Duncan T., Thiel, Uwe, Schlingmann, Karl Peter, Beetz, Rolf, Hoyer, Peter F., Konrad, Martin, Schaefer, Franz, Nürnberg, Peter, Woolf, Adrian S.

“…Urinary bladder malformations associated with bladder outlet obstruction are a frequent cause of progressive renal failure in children. We here describe a…”
Get full text

Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia by DAVIS, Belinda, DEI CAS, Alessandra, LONG, David A, WHITE, Kathryn E, HAYWARD, Anthea, KU, Ching-Hsin, WOOLF, Adrian S, BILOUS, Rudolf, VIBERTI, Giancarlo, GNUDI, Luigi

“…Angiopoietin-2 (Ang-2) modulates embryonic vascular differentiation primarily by inhibiting the antiapoptotic effects of Ang-1 on endothelia that express the…”
Get full text

HNF1B Mutations Are Associated With a Gitelman-like Tubulopathy That Develops During Childhood by Adalat, Shazia, Hayes, Wesley N., Bryant, William A., Booth, John, Woolf, Adrian S., Kleta, Robert, Subtil, Sandra, Clissold, Rhian, Colclough, Kevin, Ellard, Sian, Bockenhauer, Detlef

“…Mutations in the transcription factor hepatocyte nuclear factor 1B (HNF1B) are the most common inherited cause of renal malformations, yet also associated with…”
Get full text