Search Results - "Woodward, John J"

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking by Mahler, Stephen V, Vazey, Elena M, Beckley, Jacob T, Keistler, Colby R, McGlinchey, Ellen M, Kaufling, Jennifer, Wilson, Steven P, Deisseroth, Karl, Woodward, John J, Aston-Jones, Gary

“…The authors show that rostral ventral pallidum projections to the ventral tegmental area (VTA) are activated during cue-induced reinstatement of cocaine…”
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A brief exposure to toluene vapor alters the intrinsic excitability of D2 medium spiny neurons in the rat ventral striatum by Okas, Michael, Kastner, Abigail, Gioia, Dominic, Woodward, John J.

“…Although volatile organic solvents such as toluene are used for commercial and industrial uses, they are often voluntarily inhaled for their intoxicating and…”
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Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol by Nimitvilai, Sudarat, Lopez, Marcelo F, Mulholland, Patrick J, Woodward, John J

“…Alcoholism is associated with changes in brain reward and control systems, including the prefrontal cortex. In prefrontal areas, the orbitofrontal cortex (OFC)…”
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A review of the interactions between alcohol and the endocannabinoid system: Implications for alcohol dependence and future directions for research by Pava, Matthew J, Woodward, John J

“…Abstract Over the past fifty years a significant body of evidence has been compiled suggesting an interaction between the endocannabinoid (EC) system and…”
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Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons by Braunscheidel, Kevin, Okas, Michael, Woodward, John J

“…Inhalant abuse is an important health issue especially among children and adolescents who often encounter these agents in the home. Research into the…”
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Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference by Wayman, Wesley N, Woodward, John J

“…Abuse rates for inhalants among adolescents continue to be high, yet preclinical models for studying mechanisms underlying inhalant abuse remain limited. Our…”
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Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability by Nimitvilai, Sudarat, Lopez, Marcelo F, Mulholland, Patrick J, Woodward, John J

“…Alcohol abuse disorders are associated with dysfunction of frontal cortical areas including the orbitofrontal cortex (OFC). The OFC is extensively innervated…”
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Endocannabinoid modulation of cortical up-states and NREM sleep by Pava, Matthew J, den Hartog, Carolina R, Blanco-Centurion, Carlos, Shiromani, Priyattam J, Woodward, John J

“…Up-/down-state transitions are a form of network activity observed when sensory input into the cortex is diminished such as during non-REM sleep. Up-states…”
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The Effects of the Inhalant Toluene on Cognitive Function and Behavioral Flexibility: A Review of Recent Findings by Woodward, John J., Braunscheidel, Kevin M.

“…Substance use disorder (SUD) is characterized, in part, by lack of control over drug seeking and taking. The prefrontal cortex (PFC) is highly involved in…”
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The Abused Inhalant Toluene Differentially Modulates Excitatory and Inhibitory Synaptic Transmission in Deep-Layer Neurons of the Medial Prefrontal Cortex by BECKLEY, Jacob T, WOODWARD, John J

“…Volatile organic solvents such as toluene are voluntarily inhaled for their intoxicating effects. Solvent use is especially prevalent among adolescents, and is…”
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Ethanol Selectively Attenuates NMDAR-Mediated Synaptic Transmission in the Prefrontal Cortex by Weitlauf, Carl, Woodward, John J.

“…Background:  Brain imaging studies have revealed abnormal function in the prefrontal cortex (PFC) of alcoholics that may contribute to the impulsive behavior…”
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Self-Administration of Toluene Vapor in Rats by Braunscheidel, Kevin M, Wayman, Wesley N, Okas, Michael P, Woodward, John J

“…Inhalants, including volatile organic solvents such as toluene, continue to be one of the most prevalent, and often first substances abused by adolescents…”
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Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons by Beckley, Jacob T, Evins, Caitlin E, Fedarovich, Hleb, Gilstrap, Meghin J, Woodward, John J

“…Toluene is a volatile solvent that is intentionally inhaled by children, adolescents, and adults for its intoxicating effects. Although voluntary use of…”
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Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits by Smothers, C Thetford, Woodward, John J

“…N-Methyl-D-aspartate (NMDA) receptors are important targets for drugs of abuse such as ethanol, toluene, and ketamine. Ligand-gated ion channels assembled from…”
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Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene by Smothers, C. Thetford, Szumlinski, Karen K., Worley, Paul F., Woodward, John J.

“…ABSTRACT N‐Methyl‐D‐Aspartate (NMDA) receptors are inhibited during acute exposure to ethanol and are involved in changes in neuronal plasticity following…”
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Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors by den Hartog, Carolina R, Beckley, Jacob T, Smothers, Thetford C, Lench, Daniel H, Holseberg, Zack L, Fedarovich, Hleb, Gilstrap, Meghin J, Homanics, Gregg E, Woodward, John J

“…Ethanol's action on the brain likely reflects altered function of key ion channels such as glutamatergic N-methyl-D-aspartate receptors (NMDARs). In this…”
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Differential Effects of Toluene and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area by Nimitvilai, Sudarat, You, Chang, Arora, Devinder S, McElvain, Maureen A, Vandegrift, Bertha J, Brodie, Mark S, Woodward, John J

“…Drugs of abuse increase the activity of dopaminergic neurons of the ventral tegmental area (VTA), and output from the VTA is critical for both natural and…”
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Effects of Repeated Ethanol Exposures on NMDA Receptor Expression and Locomotor Sensitization in Mice Expressing Ethanol Resistant NMDA Receptors by den Hartog, Carolina R, Gilstrap, Meghin, Eaton, Bethany, Lench, Daniel H, Mulholland, Patrick J, Homanics, Gregg E, Woodward, John J

“…Evidence from a large number of preclinical studies suggests that chronic exposure to drugs of abuse, such as psychostimulants or ethanol induces changes in…”
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Ethanol Inhibition of Up-States in Prefrontal Cortical Neurons Expressing the Genetically Encoded Calcium Indicator GCaMP3 by Woodward, John J., Pava, Matthew

“…Background:  The prefrontal cortex (PFC) is critically involved in working memory, cognition, and decision making; processes significantly affected by ethanol…”
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Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes by Ogata, Junichi, Shiraishi, Munehiro, Namba, Tsunehisa, Smothers, C Thetford, Woodward, John J, Harris, R Adron

“…Alcohols, inhaled anesthetics, and some injectable anesthetics inhibit the function of N-methyl-d-aspartate (NMDA) receptors, but the mechanisms responsible…”
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