Search Results - "Woodson, Sarah A"

Transcription Increases the Cooperativity of Ribonucleoprotein Assembly by Rodgers, Margaret L., Woodson, Sarah A.

“…The synthesis of new ribosomes begins during transcription of the rRNA and is widely assumed to follow an orderly 5′ to 3′ gradient. To visualize…”
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Compact intermediates in RNA folding by Woodson, Sarah A

“…Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure…”
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Positive regulation by small RNAs and the role of Hfq by Soper, Toby, Mandin, Pierre, Majdalani, Nadim, Gottesman, Susan, Woodson, Sarah A

“…Bacterial small noncoding RNAs carry out both positive and negative regulation of gene expression by pairing with mRNAs; in Escherichia coli, this regulation…”
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Diversity of bacterial small RNAs drives competitive strategies for a mutual chaperone by Roca, Jorjethe, Santiago-Frangos, Andrew, Woodson, Sarah A.

“…Hundreds of bacterial small RNAs (sRNAs) require the Hfq chaperone to regulate mRNA expression. Hfq is limiting, thus competition among sRNAs for binding to…”
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RNA compaction and iterative scanning for small RNA targets by the Hfq chaperone by Małecka, Ewelina M., Woodson, Sarah A.

“…RNA-guided enzymes must quickly search a vast sequence space for their targets. This search is aided by chaperones such as Hfq, a protein that mediates…”
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C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA by Santiago-Frangos, Andrew, Kavita, Kumari, Schu, Daniel J., Gottesman, Susan, Woodson, Sarah A.

“…The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs (sRNAs) and facilitates their annealing to mRNA targets involved in stress…”
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In Vivo X-Ray Footprinting of Pre-30S Ribosomes Reveals Chaperone-Dependent Remodeling of Late Assembly Intermediates by Clatterbuck Soper, Sarah F, Dator, Romel P, Limbach, Patrick A, Woodson, Sarah A

“…Assembly of 30S ribosomal subunits from their protein and RNA components requires extensive refolding of the 16S rRNA and is assisted by 10–20 assembly factors…”
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Conserved arginines on the rim of Hfq catalyze base pair formation and exchange by Panja, Subrata, Schu, Daniel J, Woodson, Sarah A

“…The Sm-like protein Hfq is required for gene regulation by small RNAs (sRNAs) in bacteria and facilitates base pairing between sRNAs and their mRNA targets…”
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RNA Folding Pathways and the Self-Assembly of Ribosomes by Woodson, Sarah A

“…Many RNAs do not directly code proteins but are nonetheless indispensable to cellular function. These strands fold into intricate three-dimensional shapes that…”
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Structural model of an mRNA in complex with the bacterial chaperone Hfq by Peng, Yi, Curtis, Joseph E., Fang, Xianyang, Woodson, Sarah A.

“…The Sm-like protein Hfq (host factor Q-beta phage) facilitates regulation by bacterial small noncoding RNAs (sRNAs) in response to stress and other…”
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Taming free energy landscapes with RNA chaperones by Woodson, Sarah A.

“…Many non-coding RNAs fold into complex three-dimensional structures, yet the self-assembly of RNA structure is hampered by mispairing, weak tertiary…”
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Cooperative Tertiary Interaction Network Guides RNA Folding by Behrouzi, Reza, Roh, Joon Ho, Kilburn, Duncan, Briber, R.M., Woodson, Sarah A.

“…Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To understand how RNAs fold uniquely despite a small number of tertiary…”
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Molecular Crowding Stabilizes Folded RNA Structure by the Excluded Volume Effect by Kilburn, Duncan, Roh, Joon Ho, Guo, Liang, Briber, Robert M, Woodson, Sarah A

“…Crowder molecules in solution alter the equilibrium between folded and unfolded states of biological macromolecules. It is therefore critical to account for…”
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Stick-slip unfolding favors self-association of expanded HTT mRNA by O’Brien, Brett M., Moulick, Roumita, Jiménez-Avalos, Gabriel, Rajasekaran, Nandakumar, Kaiser, Christian M., Woodson, Sarah A.

“…In Huntington’s Disease (HD) and related disorders, expansion of CAG trinucleotide repeats produces a toxic gain of function in affected neurons. Expanded…”
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Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly by Woodson, Sarah A, Adilakshmi, Tadepalli, Bellur, Deepti L

“…Rapidly growing cells produce thousands of new ribosomes each minute, in a tightly regulated process that is essential to cell growth. How the Escherichia coli…”
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Increased Ribozyme Activity in Crowded Solutions by Desai, Ravi, Kilburn, Duncan, Lee, Hui-Ting, Woodson, Sarah A.

“…Noncoding RNAs must function in the crowded environment of the cell. Previous small-angle x-ray scattering experiments showed that molecular crowders stabilize…”
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Acidic C-terminal domains autoregulate the RNA chaperone Hfq by Santiago-Frangos, Andrew, Jeliazkov, Jeliazko R, Gray, Jeffrey J, Woodson, Sarah A

“…The RNA chaperone Hfq is an Sm protein that facilitates base pairing between bacterial small RNAs (sRNAs) and mRNAs involved in stress response and…”
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Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes by Abeysirigunawardena, Sanjaya C., Kim, Hajin, Lai, Jonathan, Ragunathan, Kaushik, Rappé, Mollie C., Luthey-Schulten, Zaida, Ha, Taekjip, Woodson, Sarah A.

“…Assembly of 30S ribosomes involves the hierarchical addition of ribosomal proteins that progressively stabilize the folded 16S rRNA. Here, we use three-color…”
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Major role for mRNA binding and restructuring in sRNA recruitment by Hfq by Soper, Toby J, Doxzen, Kevin, Woodson, Sarah A

“…Bacterial small RNAs (sRNAs) modulate gene expression by base-pairing with target mRNAs. Many sRNAs require the Sm-like RNA binding protein Hfq as a cofactor…”
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Ribosomal Protein S12 Hastens Nucleation of Co-Transcriptional Ribosome Assembly by Rodgers, Margaret L, Sun, Yunsheng, Woodson, Sarah A

“…Ribosomal subunits begin assembly during transcription of the ribosomal RNA (rRNA), when the rRNA begins to fold and associate with ribosomal proteins (RPs)…”
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