Search Results - "Woods, H.F."

Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation by Shaw, L, Lennard, M S, Tucker, G T, Bax, N D, Woods, H F

“…Studies were performed to investigate the irreversible binding and oxidative metabolism of propranolol in human liver microsomes and the relationship of…”
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Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type by Adams, M, Lennard, M S, Otton, S V, Tucker, G T, Woods, H F

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A model of L(+)-lactate metabolism in normal man by Connor, H, Woods, H F, Ledingham, J G, Murray, J D

“…Mathematical models were used to study the elimination of L(+)-lactate during and after an intravenous load of unlabelled sodium L(+)-lactate in 20 normal…”
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Comparison of the kinetics and utilisation of D(-)-and L(+)-sodium lactate in normal man by Connor, H, Woods, H F, Ledingham, J G

“…After infusion of sodium D(-)L(+)-lactate in healthy man the clearance of the D(-)-isomer from blood was 70% of that of the L(+)-isomer. Utilisation of…”
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The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6) by Tucker, G T, Lennard, M S, Ellis, S W, Woods, H F, Cho, A K, Lin, L Y, Hiratsuka, A, Schmitz, D A, Chu, T Y

“…The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast Saccharomyces cerevisiae expressing…”
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Utilization of L(+) lactate in patients with liver disease by Connor, H, Woods, H F, Murray, J D, Ledingham, J G

“…Clearance of intravenously infused sodium L(+) lactate was slower in 37 patients with liver disease (14.5 +/- 0.9 ml (kg BW)-1min-1) than in 20 normal subjects…”
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Clinical Manifestations of Carcinoid Disease by Bax, N.D.S., Woods, H.F., Batchelor, A., Jennings, M.

“…Carcinoid tumors are relatively uncommon tumors and their presentation is varied. For these reasons, a high index of suspicion is necessary in order to…”
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High mortality among recipients of bought living-unrelated donor kidneys by Salahudeen, A K, Woods, H F, Pingle, A, Nur-El-Huda Suleyman, M, Shakuntala, K, Nandakumar, M, Yahya, T M, Daar, A S

“…Between June, 1984, and May, 1988, 130 patients from three renal units in the United Arab Emirates and Oman went of their own accord to Bombay, where they…”
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The influence of human variability upon food safety legislation by Woods, H.F.

“…This paper considers the influence of human variations in the kinetics and dynamics of chemicals in food upon the formulation of food safety legislation…”
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Peers reviewed by Woods, H.F.

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The Polymorphic Oxidation of ??-Adrenoceptor Antagonists: Clinical Pharmacokinetic Considerations by Lennard, M.S., Tucker, G.T., Woods, H.F.

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Lack of relationships between the debrisoquine (CYP2D6) and mephenytion (CYP2C19) oxidation polymorphisms and susceptibility to breast cancer by Jennings, M., Sweetland, H., Smith, C.A.D, Wolf, C.R., Lennard, M.S., Tucker, G.T., Woods, H.F., Rogers, K.

“…The cytochrome P450 superfamily of enzymes is important in the metabolism of many drugs and in the activation of chemical carcinogens. The activities of two…”
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Abdominal carcinoid tumours in Sheffield by Woods, H F, Bax, N D, Ainsworth, I

“…The incidence, presentation, and treatment strategies of abdominal carcinoid tumours are discussed. In the Trent Region of the UK, carcinoid tumours have an…”
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Bicarbonate and cytoplasmic pH

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Metoprolol oxidation by rat liver microsomes. Inhibition by debrisoquine and other drugs by Lennard, M S, Crewe, H K, Tucker, G T, Woods, H F

“…The oxidative metabolism of metoprolol has been shown to display genetic polymorphism of the debrisoquine-type. The use of in vitro inhibition studies has been…”
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Biochemical methods in nutritional assessment by Woods, H. F

“…Nutritional measurements increasingly are replacing clinical judgements in decision-making regarding nutritional therapy of the hospitalized patient…”
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Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver by Morris, C Q, Tucker, G T, Crewe, H K, Harlow, J R, Woods, H F, Lennard, M S

“…The imidazole ring is a common structural feature of some xenobiotics that inhibit cytochrome P-450-catalysed reactions. Histamine is a 4-substituted imidazole…”
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Stereoselective 4-hydroxylation of debrisoquine in Nigerians by Lennard, M S, Tucker, G T, Woods, H F, Iyun, A O, Eichelbaum, M

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Histamine: an inhibitor of cytochrome P-450-catalysed drug metabolism by Lennard, M S, Crewe, H K, Tucker, G T, Woods, H F

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Inhibition of Drug Metabolism by β-Adrenoceptor Antagonists by Bax, N.D.S., Lennard, M.S., Al-Asady, S., Deacon, C.S., Tucker, G.T., Woods, H.F.

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