Search Results - "Woodruff, Peter J."

Chemoenzymatic Synthesis of Trehalosamine, an Aminoglycoside Antibiotic and Precursor to Mycobacterial Imaging Probes by Groenevelt, Jessica M, Meints, Lisa M, Stothard, Alicyn I, Poston, Anne W, Fiolek, Taylor J, Finocchietti, David H, Mulholand, Victoria M, Woodruff, Peter J, Swarts, Benjamin M

“…Trehalosamine (2-amino-2-deoxy-α,α-d-trehalose) is an aminoglycoside with antimicrobial activity against Mycobacterium tuberculosis, and it is also a versatile…”
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Trehalose Is Required for Growth of Mycobacterium smegmatis by Woodruff, Peter J, Carlson, Brian L, Siridechadilok, Bunpote, Pratt, Matthew R, Senaratne, Ryan H, Mougous, Joseph D, Riley, Lee W, Williams, Spencer J, Bertozzi, Carolyn R

“…Mycobacteria contain high levels of the disaccharide trehalose in free form as well as within various immunologically relevant glycolipids such as cord factor…”
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The role of chemoenzymatic synthesis in advancing trehalose analogues as tools for combatting bacterial pathogens by Kalera, Karishma, Stothard, Alicyn I, Woodruff, Peter J, Swarts, Benjamin M

“…Trehalose, a disaccharide of glucose, is increasingly recognized as an important contributor to virulence in major bacterial pathogens, such as Mycobacterium…”
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Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile by Danielson, Noah D, Collins, James, Stothard, Alicyn I, Dong, Qing Qing, Kalera, Karishma, Woodruff, Peter J, DeBosch, Brian J, Britton, Robert A, Swarts, Benjamin M

“…Trehalose is used as an additive in thousands of foods, cosmetics, and pharmaceutical products, and it is being investigated as a therapeutic for multiple…”
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Chemoenzymatic radiosynthesis of 2-deoxy-2-[18F]fluoro-d-trehalose ([18F]-2-FDTre): A PET radioprobe for in vivo tracing of trehalose metabolism by Peña-Zalbidea, Santiago, Huang, Ashley Y.-T., Kavunja, Herbert W., Salinas, Beatriz, Desco, Manuel, Drake, Christopher, Woodruff, Peter J., Vaquero, Juan J., Swarts, Benjamin M.

“…Trehalose analogues bearing fluorescent and click chemistry tags have been developed as probes of bacterial trehalose metabolism, but these tools have…”
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The trehalose-specific transporter LpqY-SugABC is required for antimicrobial and anti-biofilm activity of trehalose analogues in Mycobacterium smegmatis by Wolber, Jeffrey M., Urbanek, Bailey L., Meints, Lisa M., Piligian, Brent F., Lopez-Casillas, Irene C., Zochowski, Kailey M., Woodruff, Peter J., Swarts, Benjamin M.

“…Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess distinctive pathways for synthesizing and utilizing the non-mammalian…”
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Chemoenzymatic Synthesis of Trehalose Analogues: Rapid Access to Chemical Probes for Investigating Mycobacteria by Urbanek, Bailey L., Wing, Douglas C., Haislop, Krystal S., Hamel, Chelsey J., Kalscheuer, Rainer, Woodruff, Peter J., Swarts, Benjamin M.

“…Trehalose analogues are emerging as valuable tools for investigating Mycobacterium tuberculosis, but progress in this area is slow due to the difficulty in…”
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Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift by Kalera, Karishma, Liu, Rachel, Lim, Juhyeon, Pathirage, Rasangi, Swanson, Daniel H., Johnson, Ulysses G., Stothard, Alicyn I., Lee, Jae Jin, Poston, Anne W., Woodruff, Peter J., Ronning, Donald R., Eoh, Hyungjin, Swarts, Benjamin M.

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death worldwide by infectious disease. Treatment of Mtb infection…”
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Chromate reduction is expedited by bacteria engineered to produce the compatible solute trehalose by Frederick, Tamlyn M, Taylor, Erin A, Willis, Jennifer L, Shultz, Matthew S, Woodruff, Peter J

“…The toxicity and solubility of chromium(VI) can be decreased by certain microbes that reduce chromium(VI) to chromium(III). However, these bacteria do not…”
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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues by Meints, Lisa M, Poston, Anne W, Piligian, Brent F, Olson, Claire D, Badger, Katherine S, Woodruff, Peter J, Swarts, Benjamin M

“…Chemically modified versions of trehalose, or trehalose analogues, have applications in biology, biotechnology, and pharmaceutical science, among other fields…”
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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues by Meints, Lisa M., Poston, Anne W., Piligian, Brent F., Olson, Claire D., Badger, Katherine S., Woodruff, Peter J., Swarts, Benjamin M.

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