Search Results - "Woodruff, Matthew"

Extrafollicular responses in humans and SLE by Jenks, Scott A., Cashman, Kevin S., Woodruff, Matthew C., Lee, F. Eun‐Hyung, Sanz, Ignacio

“…Summary Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are endowed with a long‐standing autoreactive B‐cell compartment…”
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Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines by Lee, Jisun, Woodruff, Matthew C., Kim, Eui Ho, Nam, Jae-Hwan

“…Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to wield them in the development of therapeutics and vaccines. During the…”
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Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus by Jenks, Scott A., Cashman, Kevin S., Zumaquero, Esther, Marigorta, Urko M., Patel, Aakash V., Wang, Xiaoqian, Tomar, Deepak, Woodruff, Matthew C., Simon, Zoe, Bugrovsky, Regina, Blalock, Emily L., Scharer, Christopher D., Tipton, Christopher M., Wei, Chungwen, Lim, S. Sam, Petri, Michelle, Niewold, Timothy B., Anolik, Jennifer H., Gibson, Greg, Lee, F. Eun-Hyung, Boss, Jeremy M., Lund, Frances E., Sanz, Ignacio

“…Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double negative; DN). We show that DN cell expansions reflected a subset…”
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Systems biology of B cells in COVID-19 by Woodruff, Matthew C., Faliti, Caterina E., Sanz, Ignacio

“…The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on…”
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Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Nguyen, Doan C., Cashman, Kevin S., Saini, Ankur Singh, Haddad, Natalie S., Ley, Ariel M., Kyu, Shuya, Howell, J. Christina, Ozturk, Tugba, Lee, Saeyun, Suryadevara, Naveenchandra, Case, James Brett, Bugrovsky, Regina, Chen, Weirong, Estrada, Jacob, Morrison-Porter, Andrea, Derrico, Andrew, Anam, Fabliha A., Sharma, Monika, Wu, Henry M., Le, Sang N., Jenks, Scott A., Tipton, Christopher M., Staitieh, Bashar, Daiss, John L., Ghosn, Eliver, Diamond, Michael S., Carnahan, Robert H., Crowe, James E., Hu, William T., Lee, F. Eun-Hyung, Sanz, Ignacio

“…A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic,…”
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The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture by Astarita, Jillian L, Cremasco, Viviana, Fu, Jianxin, Darnell, Max C, Peck, James R, Nieves-Bonilla, Janice M, Song, Kai, Kondo, Yuji, Woodruff, Matthew C, Gogineni, Alvin, Onder, Lucas, Ludewig, Burkhard, Weimer, Robby M, Carroll, Michael C, Mooney, David J, Xia, Lijun, Turley, Shannon J

“…Lymph nodes expand after an inflammatory challenge to accommodate their increased cellularity. Turley and colleagues show that fibroblastic reticular cells…”
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B cell homeostasis and follicle confines are governed by fibroblastic reticular cells by Cremasco, Viviana, Woodruff, Matthew C, Onder, Lucas, Cupovic, Jovana, Nieves-Bonilla, Janice M, Schildberg, Frank A, Chang, Jonathan, Cremasco, Floriana, Harvey, Christopher J, Wucherpfennig, Kai, Ludewig, Burkhard, Carroll, Michael C, Turley, Shannon J

“…Naive B and T cells exist in discrete zones in lymph nodes. Turley and colleagues demonstrate that a distinct subset of fibroblastic reticular cells reside in…”
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Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID by Woodruff, Matthew C., Bonham, Kevin S., Anam, Fabliha A., Walker, Tiffany A., Faliti, Caterina E., Ishii, Yusho, Kaminski, Candice Y., Ruunstrom, Martin C., Cooper, Kelly Rose, Truong, Alexander D., Dixit, Adviteeya N., Han, Jenny E., Ramonell, Richard P., Haddad, Natalie S., Rudolph, Mark E., Yalavarthi, Srilakshmi, Betin, Viktoria, Natoli, Ted, Navaz, Sherwin, Jenks, Scott A., Zuo, Yu, Knight, Jason S., Khosroshahi, Arezou, Lee, F. Eun-Hyung, Sanz, Ignacio

“…While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to…”
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Mild antecedent COVID-19 associated with symptom-specific post-acute sequelae by Walker, Tiffany A, Truong, Alex D, Summers, Aerica, Dixit, Adviteeya N, Goldstein, Felicia C, Hajjar, Ihab, Echols, Melvin R, Woodruff, Matthew C, Lee, Erica D, Tekwani, Seema, Carroll, Kelley, Sanz, Ignacio, Lee, F Eun-Hyung, Han, Jenny E

“…The impact of COVID-19 severity on development of long-term sequelae remains unclear, and symptom courses are not well defined. This ambidirectional cohort…”
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Dysregulated naive B cells and de novo autoreactivity in severe COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Haddad, Natalie S., Anam, Fabliha A., Rudolph, Mark E., Walker, Tiffany A., Truong, Alexander D., Dixit, Adviteeya N., Han, Jenny E., Cabrera-Mora, Monica, Runnstrom, Martin C., Bugrovsky, Regina, Hom, Jennifer, Connolly, Erin C., Albizua, Igor, Javia, Vidhi, Cashman, Kevin S., Nguyen, Doan C., Kyu, Shuya, Singh Saini, Ankur, Piazza, Michael, Tipton, Christopher M., Khosroshahi, Arezou, Gibson, Greg, Martin, Greg S., Maier, Cheryl L., Esper, Annette, Jenks, Scott A., Lee, F. Eun-Hyung, Sanz, Ignacio

“…Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic 2 – 5 . More…”
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Many objective visual analytics: rethinking the design of complex engineered systems by Woodruff, Matthew J., Reed, Patrick M., Simpson, Timothy W.

“…Many cognitive and computational challenges accompany the design of complex engineered systems. This study proposes the many-objective visual analytics (MOVA)…”
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COVID‐19 and plasma cells: Is there long‐lived protection? by Nguyen, Doan C., Lamothe, Pedro A., Woodruff, Matthew C., Saini, Ankur S., Faliti, Caterina E., Sanz, Ignacio, Lee, Frances Eun‐Hyung

“…Summary Infection with SARS‐CoV‐2, the etiology of the ongoing COVID‐19 pandemic, has resulted in over 450 million cases with more than 6 million deaths…”
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Understanding and measuring human B‐cell tolerance and its breakdown in autoimmune disease by Cashman, Kevin S., Jenks, Scott A., Woodruff, Matthew C., Tomar, Deepak, Tipton, Christopher M., Scharer, Christopher D., Eun‐Hyung Lee, F., Boss, Jeremy M., Sanz, Iñaki

“…The maintenance of immunological tolerance of B lymphocytes is a complex and critical process that must be implemented as to avoid the detrimental development…”
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Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway by Kim, Eui Ho, Woodruff, Matthew C, Grigoryan, Lilit, Maier, Barbara, Lee, Song Hee, Mandal, Pratyusha, Cortese, Mario, Natrajan, Muktha S, Ravindran, Rajesh, Ma, Huailiang, Merad, Miriam, Gitlin, Alexander D, Mocarski, Edward S, Jacob, Joshy, Pulendran, Bali

“…The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both…”
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Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture by Nguyen, Doan C., Saney, Celia, Hentenaar, Ian T., Cabrera-Mora, Monica, Capric, Violeta, Woodruff, Matthew C., Andrews, Joel, Lonial, Sagar, Sanz, Ignacio, Lee, F. Eun-Hyung

“…Following infection or vaccination, early-minted antibody secreting cells (ASC) or plasmablasts appear in circulation transiently, and a small fraction…”
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B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus by Jenks, Scott A, Wei, Chungwen, Bugrovsky, Regina, Hill, Aisha, Wang, Xiaoqian, Rossi, Francesca M, Cashman, Kevin, Woodruff, Matthew C, Aspey, Laura D, Lim, S Sam, Bao, Gaobin, Drenkard, Cristina, Sanz, Ignacio

“…While the contribution of B-cells to SLE is well established, its role in chronic cutaneous lupus erythematosus (CCLE) remains unclear. Here, we compare B-cell…”
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Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations by Sanz, Ignacio, Wei, Chungwen, Jenks, Scott A, Cashman, Kevin S, Tipton, Christopher, Woodruff, Matthew C, Hom, Jennifer, Lee, F Eun-Hyung

“…The increasingly recognized role of different types of B cells and plasma cells in protective and pathogenic immune responses combined with technological…”
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GLaMST: grow lineages along minimum spanning tree for b cell receptor sequencing data by Yang, Xingyu, Tipton, Christopher M, Woodruff, Matthew C, Zhou, Enlu, Lee, F Eun-Hyung, Sanz, Inãki, Qiu, Peng

“…B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor…”
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Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus by Chen, Weirong, Hong, So-Hee, Jenks, Scott A., Anam, Fabliha A., Tipton, Christopher M., Woodruff, Matthew C., Hom, Jennifer R., Cashman, Kevin S., Faliti, Caterina Elisa, Wang, Xiaoqian, Kyu, Shuya, Wei, Chungwen, Scharer, Christopher D., Mi, Tian, Hicks, Sakeenah, Hartson, Louise, Nguyen, Doan C., Khosroshahi, Arezou, Lee, Saeyun, Wang, Youliang, Bugrovsky, Regina, Ishii, Yusho, Lee, F. Eun-Hyung, Sanz, Ignacio

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells…”
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Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes by Jafarnejad, Mohammad, Woodruff, Matthew C, Zawieja, David C, Carroll, Michael C, Moore, Jr, J E

“…Lymph nodes (LNs) are positioned strategically throughout the body as critical mediators of lymph filtration and immune response. Lymph carries cytokines,…”
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