Search Results - "Woodruff, G. N."

The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine by SINGH, L, FIELD, M. J, FERRIS, P, HUNTER, J. C, OLES, R. J, WILLIAMS, R. G, WOODRUFF, G. N

“…This report describes the activity of the antiepileptic agent gabapentin (Neurontin) in animal models predictive of anxiolysis and analgesia. Gabapentin…”
Get full text

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil by Gill, R, Foster, AC, Woodruff, GN

“…The neuroprotective effects of MK-801, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, were evaluated in models of cerebral ischemia…”
Get full text

Development of a Class of Selective Cholecystokinin Type B Receptor Antagonists Having Potent Anxiolytic Activity by Hughes, J., Boden, P., Costall, B., Domeney, A., Kelly, E., Horwell, D. C., Hunter, J. C., Pinnock, R. D., Woodruff, G. N.

“…PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50values of 1.6 nM and 3.5 nM, respectively,…”
Get full text

The Anticonvulsant MK-801 is a Potent N-methyl-D-aspartate Antagonist by Erik H. F. Wong, Kemp, John A., Priestley, Tony, Knight, Antony R., Woodruff, Geoffrey N., Iversen, Leslie L.

“…The compound MK-801 {(+)-5-methyl-10,11- dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate)} is a potent anticonvulsant that is active after oral…”
Get full text

7-Chlorokynurenic Acid is a Selective Antagonist at the Glycine Modulatory Site of the N-methyl-D-aspartate Receptor Complex by Kemp, J. A., Foster, A. C., Lesson, P. D., Priestley, T., Tridgett, R., Iversen, L. L., Woodruff, G. N.

“…Glycine markedly potentiates N-methyl-D-aspartate (N-Me-D-Asp) responses in mammalian neurons by an action at a modulatory site on the N-Me-D-Asp…”
Get full text

Evidence for an Involvement of the Brain Cholecystokinin B Receptor in Anxiety by Singh, L., Lewis, A. S., Field, M. J., Hughes, J., Woodruff, G. N.

“…The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective…”
Get full text

Cholecystokinin antagonists by Woodruff, G N, Hughes, J

Get full text

Autoradiographic localization and biochemical characterization of peripheral type CCK receptors in rat CNS using highly selective nonpeptide CCK antagonists by Hill, DR, Campbell, NJ, Shaw, TM, Woodruff, GN

“…Two potent and highly selective nonpeptide antagonists, L-365,031 [1-methyl-3-(4-bromobenzoyl)amino-5-phenyl-3H-1,4 benzodiazepin-2-one] and 3H-L-364,718…”
Get full text

Protective effect of the glutamate antagonist, MK-801 in focal cerebral ischemia in the cat by Ozyurt, E, Graham, D I, Woodruff, G N, McCulloch, J

“…The effects of the glutamate N-methyl-D aspartate (NMDA) receptor antagonist, MK-801, upon ischemic brain damage has been examined in anesthetized cats. Focal…”
Get more information

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period by Gill, R, Foster, A C, Woodruff, G N

“…The neuroprotective effects of the non-competitive N-methyl-D-aspartate receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine…”
Get more information

Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies by Suman-Chauhan, N, Webdale, L, Hill, D R, Woodruff, G N

“…The binding characteristics of [3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were…”
Get more information

Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms by Marshall, F H, Barnes, S, Hughes, J, Woodruff, G N, Hunter, J C

“…The effects of various cholecystokinin (CCK)-related peptides were investigated on 35 mM K(+)-stimulated endogenous dopamine release from slices of either…”
Get more information

The neuroprotective action of dizocilpine (MK‐801) in the rat middle cerebral artery occlusion model of focal ischaemia by Gill, R., Brazell, C., Woodruff, G.N., Kemp, J.A.

“…1 An acute model of focal ischaemia, which involves permanent occlusion of the middle cerebral artery of the rat with 4 h survival, was used to find the…”
Get full text

The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia by Gill, R, Woodruff, G N

“…The broad spectrum excitatory amino acid antagonist, kynurenic acid was evaluated in a transient forebrain ischaemia model in gerbils. When administered i.p.,…”
Get more information

Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies by Hill, D R, Suman-Chauhan, N, Woodruff, G N

“…The autoradiographical distribution of [3H]gabapentin, the tritiated analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid)…”
Get more information

[3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes by Wong, E H, Knight, A R, Woodruff, G N

“…The potent noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist [3H]MK-801 bound with nanomolar affinity to rat brain membranes in a reversible,…”
Get more information

The behavioural properties of CI‐988, a selective cholecystokininB receptor antagonist by Singh, Lakhbir, Field, Mark J., Hughes, John, Menzies, Richard, Oles, Ryszard J., Vass, Caroline A., Woodruff, Geoffrey N.

“…1 The behavioural effects of a selective cholecystokininB (CCKB) receptor antagonist CI‐988 were investigated in rodents. 2 In three rodent tests of anxiety…”
Get full text

Spermine modulation of specific [3H]‐gabapentin binding to the detergent‐solubilized porcine cerebral cortex α2δ calcium channel subunit by Dissanayake, V U K, Gee, N S, Brown, J P, Woodruff, G N

“…Recent studies have identified the [3H]‐gabapentin‐binding protein, purified from porcine cerebral cortical membranes, as the α2δ subunit of voltage‐sensitive…”
Get full text

Comparison of the autoradiographic binding distribution of [3H]‐gabapentin with excitatory amino acid receptor and amino acid uptake site distributions in rat brain by Thurlow, Richard J., Hill, David R., Woodruff, G.N.

“…1 Gabapentin is a novel anticonvulsant with an unknown mechanism of action. Recent homogenate binding studies with [3H]‐gabapentin have suggested a…”
Get full text

The interaction of the NK1 receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences by Guard, S., Boyle, S.J., Tang, K.‐W., Watling, K.J., McKnight, A.T., Woodruff, G.N.

“…1 We investigated the effects of the non‐peptide NK1 receptor antagonist, CP‐96,345, its inactive enantiomer CP‐96,344, and the racemic mixture (±)‐CP‐96,345,…”
Get full text