Search Results - "Woodrow, R."

Solving Differential Equations in R : Package deSolve by Soetaert, Karline, Petzoldt, Thomas, Setzer, R. Woodrow

“…In this paper we present the R package deSolve to solve initial value problems (IVP) written as ordinary differential equations (ODE), differential algebraic…”
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Shape and steepness of toxicological dose-response relationships of continuous endpoints by Slob, Wout, Setzer, R. Woodrow

“…Abstract A re-analysis of a large number of historical dose-response data for continuous endpoints indicates that an exponential or a Hill model with four…”
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tcpl: the ToxCast pipeline for high-throughput screening data by Filer, Dayne L, Kothiya, Parth, Setzer, R Woodrow, Judson, Richard S, Martin, Matthew T

“…Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can…”
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httk: R Package for High-Throughput Toxicokinetics by Pearce, Robert G, Setzer, R Woodrow, Strope, Cory L, Wambaugh, John F, Sipes, Nisha S

“…Thousands of chemicals have been profiled by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of…”
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Toxicokinetic Triage for Environmental Chemicals by Wambaugh, John F, Wetmore, Barbara A, Pearce, Robert, Strope, Cory, Goldsmith, Rocky, Sluka, James P, Sedykh, Alexander, Tropsha, Alex, Bosgra, Sieto, Shah, Imran, Judson, Richard, Thomas, Russell S, Setzer, R Woodrow

“…Toxicokinetic (TK) models link administered doses to plasma, blood, and tissue concentrations. High-throughput TK (HTTK) performs in vitro to in vivo…”
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Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor by Judson, Richard S, Magpantay, Felicia Maria, Chickarmane, Vijay, Haskell, Cymra, Tania, Nessy, Taylor, Jean, Xia, Menghang, Huang, Ruili, Rotroff, Daniel M, Filer, Dayne L, Houck, Keith A, Martin, Matthew T, Sipes, Nisha, Richard, Ann M, Mansouri, Kamel, Setzer, R Woodrow, Knudsen, Thomas B, Crofton, Kevin M, Thomas, Russell S

“…We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding,…”
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Benchmarking a High-Fidelity Mixed-Species Entangling Gate by Hughes, A C, Schäfer, V M, Thirumalai, K, Nadlinger, D P, Woodrow, S R, Lucas, D M, Ballance, C J

“…We implement a two-qubit logic gate between a ^{43}Ca^{+} hyperfine qubit and a ^{88}Sr^{+} Zeeman qubit. For this pair of ion species, the S-P optical…”
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Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation by Kapraun, Dustin F, Wambaugh, John F, Setzer, R Woodrow, Judson, Richard S

“…Many parameters treated as constants in traditional physiologically based pharmacokinetic models must be formulated as time-varying quantities when modeling…”
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High Throughput Heuristics for Prioritizing Human Exposure to Environmental Chemicals by Wambaugh, John F, Wang, Anran, Dionisio, Kathie L, Frame, Alicia, Egeghy, Peter, Judson, Richard, Setzer, R. Woodrow

“…The risk posed to human health by any of the thousands of untested anthropogenic chemicals in our environment is a function of both the hazard presented by the…”
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High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis by Haggard, Derik E, Karmaus, Agnes L, Martin, Matthew T, Judson, Richard S, Setzer, R Woodrow, Paul Friedman, Katie

“…Abstract The U.S. Environmental Protection Agency Endocrine Disruptor Screening Program and the Organization for Economic Co-operation and Development (OECD)…”
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A Method for Identifying Prevalent Chemical Combinations in the U.S. Population by Kapraun, Dustin F, Wambaugh, John F, Ring, Caroline L, Tornero-Velez, Rogelio, Setzer, R Woodrow

“…Through the food and water they ingest, the air they breathe, and the consumer products with which they interact at home and at work, humans are exposed to…”
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High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project by Wambaugh, John F, Setzer, R. Woodrow, Reif, David M, Gangwal, Sumit, Mitchell-Blackwood, Jade, Arnot, Jon A, Joliet, Olivier, Frame, Alicia, Rabinowitz, James, Knudsen, Thomas B, Judson, Richard S, Egeghy, Peter, Vallero, Daniel, Cohen Hubal, Elaine A

“…The United States Environmental Protection Agency (U.S. EPA) must characterize potential risks to human health and the environment associated with manufacture…”
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The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals by Dix, David J., Houck, Keith A., Martin, Matthew T., Richard, Ann M., Setzer, R. Woodrow, Kavlock, Robert J.

“…The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various…”
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Characterizing surface water concentrations of hundreds of organic chemicals in United States for environmental risk prioritization by Sayre, Risa R., Setzer, R. Woodrow, Serre, Marc L., Wambaugh, John F.

“…Background Thousands of chemicals are observed in freshwater, typically at trace levels. Measurements are collected for different purposes, so sample…”
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Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability by Ring, Caroline L., Pearce, Robert G., Setzer, R. Woodrow, Wetmore, Barbara A., Wambaugh, John F.

“…The thousands of chemicals present in the environment (USGAO, 2013) must be triaged to identify priority chemicals for human health risk research. Most…”
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Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data by Stanfield, Zachary, Setzer, R Woodrow, Hull, Victoria, Sayre, Risa R, Isaacs, Kristin K, Wambaugh, John F

“…Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals…”
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Consensus Modeling of Median Chemical Intake for the U.S. Population Based on Predictions of Exposure Pathways by Ring, Caroline L, Arnot, Jon A, Bennett, Deborah H, Egeghy, Peter P, Fantke, Peter, Huang, Lei, Isaacs, Kristin K, Jolliet, Olivier, Phillips, Katherine A, Price, Paul S, Shin, Hyeong-Moo, Westgate, John N, Setzer, R. Woodrow, Wambaugh, John F

“…Prioritizing the potential risk posed to human health by chemicals requires tools that can estimate exposure from limited information. In this study, chemical…”
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Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics by Wambaugh, John F, Hughes, Michael F, Ring, Caroline L, MacMillan, Denise K, Ford, Jermaine, Fennell, Timothy R, Black, Sherry R, Snyder, Rodney W, Sipes, Nisha S, Wetmore, Barbara A, Westerhout, Joost, Setzer, R Woodrow, Pearce, Robert G, Simmons, Jane Ellen, Thomas, Russell S

“…Abstract Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data,…”
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A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model by Judson, Richard, Elloumi, Fathi, Setzer, R Woodrow, Li, Zhen, Shah, Imran

“…Bioactivity profiling using high-throughput in vitro assays can reduce the cost and time required for toxicological screening of environmental chemicals and…”
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Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing by Wetmore, Barbara A, Wambaugh, John F, Allen, Brittany, Ferguson, Stephen S, Sochaski, Mark A, Setzer, R Woodrow, Houck, Keith A, Strope, Cory L, Cantwell, Katherine, Judson, Richard S, LeCluyse, Edward, Clewell, Harvey J, Thomas, Russell S, Andersen, Melvin E

“…We previously integrated dosimetry and exposure with high-throughput screening (HTS) to enhance the utility of ToxCast HTS data by translating in vitro…”
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