Search Results - "Woodrow, D"

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    Human Genetics of Hypoplastic Left Heart Syndrome by Pfitzer, Constanze, Schmitt, Katharina R L, Benson, Woodrow D

    “…Hypoplastic left heart syndrome (HLHS) is a severe congenital cardiovascular malformation characterized by hypoplasia of the left ventricle, aorta, and other…”
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    Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves by Hinton, Robert B, Lincoln, Joy, Deutsch, Gail H, Osinska, Hanna, Manning, Peter B, Benson, D Woodrow, Yutzey, Katherine E

    Published in Circulation research (09-06-2006)
    “…Heart valve disease is an important cause of morbidity and mortality worldwide. Little is known about valve disease pathogenesis, but increasing evidence…”
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    Hypoplastic Left Heart Syndrome Links to Chromosomes 10q and 6q and Is Genetically Related to Bicuspid Aortic Valve by Hinton, Robert B., MD, Martin, Lisa J., PhD, Rame-Gowda, Smitha, PhD, Tabangin, Meredith E., MPH, Cripe, Linda H., MD, Benson, D. Woodrow, MD, PhD

    “…Objectives This study was designed to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the genetic relationship between HLHS and…”
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    Fetal Heart Rate Predictors of Long QT Syndrome by MITCHELL, Jason L, CUNEO, Bettina F, ETHERIDGE, Susan P, HORIGOME, Hitoshi, WENG, Hsin-Yi, WOODROW BENSON, D

    Published in Circulation (New York, N.Y.) (04-12-2012)
    “…Fetal long QT syndrome (LQTS) is associated with complex arrhythmias including torsades de pointes and 2° atrioventricular block. Sinus bradycardia has also…”
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    Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects and abnormal ventricular morphology in mice by Ye, Maoqing, Coldren, Chris, Liang, Xingqun, Mattina, Teresa, Goldmuntz, Elizabeth, Benson, D. Woodrow, Ivy, Dunbar, Perryman, M.B., Garrett-Sinha, Lee Ann, Grossfeld, Paul

    Published in Human molecular genetics (15-02-2010)
    “…Congenital heart defects comprise the most common form of major birth defects, affecting 0.7% of all newborn infants. Jacobsen syndrome (11q-) is a rare…”
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    Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model by Cirrito, John R., Wallace, Clare E., Yan, Ping, Davis, Todd A., Gardiner, Woodrow D., Doherty, Brookelyn M., King, Diana, Yuede, Carla M., Lee, Jin-Moo, Sheline, Yvette I.

    Published in Neurology (10-11-2020)
    “…BACKGROUNDSeveral neurotransmitter receptors activate signaling pathways that alter processing of the amyloid precursor protein (APP) into β-amyloid (Aβ)…”
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    Hypoplastic Left Heart Syndrome Is Heritable by Hinton, Robert B., MD, Martin, Lisa J., PhD, Tabangin, Meredith E., MPH, Mazwi, Mjaye L., MD, Cripe, Linda H., MD, Benson, D. Woodrow, MD, PhD

    “…Hypoplastic Left Heart Syndrome Is Heritable Robert B. Hinton, Jr, Lisa J. Martin, Meredith E. Tabangin, Mjaye L. Mazwi, Linda H. Cripe, D. Woodrow Benson…”
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    Spectrum of heart disease associated with murine and human GATA4 mutation by Rajagopal, Satish K, Ma, Qing, Obler, Dita, Shen, Jie, Manichaikul, Ani, Tomita-Mitchell, Aoy, Boardman, Kari, Briggs, Christine, Garg, Vidu, Srivastava, Deepak, Goldmuntz, Elizabeth, Broman, Karl W, Woodrow Benson, D, Smoot, Leslie B, Pu, William T

    “…Abstract The transcription factor GATA4 is essential for heart morphogenesis. Heterozygous mutation of GATA4 causes familial septal defects. However, the…”
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    Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides by Bamborough, Paul, Diallo, Hawa, Goodacre, Jonathan D, Gordon, Laurie, Lewis, Antonia, Seal, Jonathan T, Wilson, David M, Woodrow, Michael D, Chung, Chun-wa

    Published in Journal of medicinal chemistry (26-01-2012)
    “…Bromodomains are epigenetic reader modules that regulate gene transcription through their recognition of acetyl-lysine modified histone tails. Inhibitors of…”
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