Search Results - "Woodfin, Ashley R"

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II by Chen, Fei Xavier, Woodfin, Ashley R., Gardini, Alessandro, Rickels, Ryan A., Marshall, Stacy A., Smith, Edwin R., Shiekhattar, Ramin, Shilatifard, Ali

“…The control of promoter-proximal pausing and the release of RNA polymerase II (Pol II) is a widely used mechanism for regulating gene expression in metazoans,…”
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II via Transcriptional Elongation Control in Mitosis by Liang, Kaiwei, Woodfin, Ashley R., Slaughter, Brian D., Unruh, Jay R., Box, Andrew C., Rickels, Ryan A., Gao, Xin, Haug, Jeffrey S., Jaspersen, Sue L., Shilatifard, Ali

“…Although it is established that some general transcription factors are inactivated at mitosis, many details of mitotic transcription inhibition (MTI) and its…”
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy by Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali

“…The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and…”
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An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS by Rickels, Ryan, Hu, Deqing, Collings, Clayton K., Woodfin, Ashley R., Piunti, Andrea, Mohan, Man, Herz, Hans-Martin, Kvon, Evgeny, Shilatifard, Ali

“…Polycomb response elements (PREs) are specific DNA sequences that stably maintain the developmental pattern of gene expression. Drosophila PREs are well…”
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High-throughput robust single-cell DNA methylation profiling with sciMETv2 by Nichols, Ruth V., O’Connell, Brendan L., Mulqueen, Ryan M., Thomas, Jerushah, Woodfin, Ashley R., Acharya, Sonia, Mandel, Gail, Pokholok, Dmitry, Steemers, Frank J., Adey, Andrew C.

“…DNA methylation is a key epigenetic property that drives gene regulatory programs in development and disease. Current single-cell methods that produce high…”
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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia by Liang, Kaiwei, Volk, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali

“…Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite…”
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Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity by Luo, Zhuojuan, Lin, Chengqi, Woodfin, Ashley R, Bartom, Elizabeth T, Gao, Xin, Smith, Edwin R, Shilatifard, Ali

“…Genomic imprinting is a critical developmental process characteristic of parent of origin-specific gene expression. It is well accepted that differentially…”
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Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation by Thornton, Janet L, Westfield, Gerwin H, Takahashi, Yoh-Hei, Cook, Malcolm, Gao, Xin, Woodfin, Ashley R, Lee, Jung-Shin, Morgan, Marc A, Jackson, Jessica, Smith, Edwin R, Couture, Jean-Francois, Skiniotis, Georgios, Shilatifard, Ali

“…The stimulation of trimethylation of histone H3 Lys4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied, with multiple mechanisms having been…”
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NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release by Aoi, Yuki, Smith, Edwin R., Shah, Avani P., Rendleman, Emily J., Marshall, Stacy A., Woodfin, Ashley R., Chen, Fei X., Shiekhattar, Ramin, Shilatifard, Ali

“…RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions in most metazoans, and based on in vitro studies, this function has been…”
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A high‐throughput method to identify trans‐activation domains within transcription factor sequences by Arnold, Cosmas D, Nemčko, Filip, Woodfin, Ashley R, Wienerroither, Sebastian, Vlasova, Anna, Schleiffer, Alexander, Pagani, Michaela, Rath, Martina, Stark, Alexander

“…Even though transcription factors (TFs) are central players of gene regulation and have been extensively studied, their regulatory trans ‐activation domains…”
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Resolving systematic errors in widely used enhancer activity assays in human cells by Muerdter, Felix, Boryń, Łukasz M, Woodfin, Ashley R, Neumayr, Christoph, Rath, Martina, Zabidi, Muhammad A, Pagani, Michaela, Haberle, Vanja, Kazmar, Tomáš, Catarino, Rui R, Schernhuber, Katharina, Arnold, Cosmas D, Stark, Alexander

“…Using the ORI of plasmids used in enhancer assays as the sole core promoter and inhibiting the interferon I response triggered by plasmid transfection greatly…”
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Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation by Haddad, John Faissal, Yang, Yidai, Takahashi, Yoh-hei, Joshi, Monika, Chaudhary, Nidhi, Woodfin, Ashley R., Benyoucef, Aissa, Yeung, Sylvain, Brunzelle, Joseph S., Skiniotis, Georgios, Brand, Marjorie, Shilatifard, Ali, Couture, Jean-François

“…Dpy-30 is a regulatory subunit controlling the histone methyltransferase activity of the KMT2 enzymes in vivo. Paradoxically, in vitro methyltransferase assays…”
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Therapeutic targeting of MLL degradation pathways in MLL‐rearranged leukemia by Liang, Kaiwei, Volk, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali

“…Abstract only Chromosomal translocations of the mixed‐lineage leukemia ( MLL ) gene with various partner genes result in aggressive MLL leukemia with dismal…”
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