Search Results - "Woodard, R W"

Structures of Aquifex aeolicus KDO8P Synthase in Complex with R5P and PEP, and with a Bisubstrate Inhibitor:  Role of Active Site Water in Catalysis by Wang, Jian, Duewel, Henry S, Woodard, Ronald W, Gatti, Domenico L

“…We have determined the crystal structures of the metalloenzyme 3-deoxy-d-manno-octulosonate 8-phosphate (KDO8P) synthase from Aquifex aeolicus in complex with…”
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Permeation of buprenorphine and its 3-alkyl-ester prodrugs through human skin by STINCHCOMB, A. L, PALIWAL, A, DUA, R, IMOTO, H, WOODARD, R. W, FLYNN, G. L

“…Homologous 3-alkyl-ester prodrugs (C2 to C4) of buprenorphine with decreased crystallinity have been synthesized and evaluated for transdermal delivery…”
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A solubility and related physicochemical property comparison of buprenorphine and its 3-alkyl esters by STINCHCOMB, A. L, RAJESH DUA, ANUPAM PALIWAL, WOODARD, R. W, FLYNN, G. L

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A Single Point Mutation in 3-Deoxy-d-manno-octulosonate-8-phosphate Synthase Is Responsible for Temperature Sensitivity in a Mutant Strain of Salmonella typhimurium by Taylor, William P., Sheflyan, Galina Ya, Woodard, Ronald W.

“…Salmonella typhimurium mutants conditionally deficient in 3-deoxy-d-manno-octulosonate-8-phosphate (KDO8P) synthase activity play a central role in our…”
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Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages by Pufahl, Robert A, Nanjappan, Palaniappa G, Woodard, Ronald W, Marletta, Michael A

“…NG-Hydroxy-L-arginine, [15N]-NG-hydroxy-L-arginine, and NG-hydroxy-NG- methyl-L-arginine were used as mechanistic probes of the initial step in the reaction…”
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Stereochemistry of 3-deoxyoctulosonate 8-phosphate synthase by Dotson, Garry D, Nanjappan, Palaniappagownder, Reily, Michael D, Woodard, Ronald W

“…(Z)- and (E)-[3-2H]phosphoenolpyruvate were prepared chemically by the reductive deuteration of (Z)- and (E)-3-bromophosphoenolpyruvate, respectively, and were…”
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Substrate Ambiguity of 3-Deoxy-d-manno-Octulosonate 8-Phosphate Synthase from Neisseria gonorrhoeae Revisited by Sheflyan, G Y, Sundaram, A K, Taylor, W P, Woodard, R W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Escherichia coli YrbI Is 3-Deoxy-d-manno-octulosonate 8-Phosphate Phosphatase by Wu, Jing, Woodard, Ronald W

“…3-Deoxy- d - manno -octulosonate 8-phosphate (KDO 8-P) phosphatase, which catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate, is the last…”
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Crystal structure of the reaction complex of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Thermotoga maritima refines the catalytic mechanism and indicates a new mechanism of allosteric regulation by Shumilin, Igor A, Bauerle, Ronald, Wu, Jing, Woodard, Ronald W, Kretsinger, Robert H

“…3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) catalyzes the first reaction of the aromatic biosynthetic pathway in bacteria, fungi, and plants,…”
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Escherichia coli YrbH Is a D-Arabinose 5-Phosphate Isomerase by Meredith, Timothy C., Woodard, Ronald W.

“…A gene encoding for arabinose 5-phosphate isomerase (API), which catalyzes the interconversion of d-ribulose 5-phosphate (Ru5P) and d-arabinose 5-phosphate…”
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Characterization of Escherichia coli D-arabinose 5-phosphate isomerase encoded by kpsF: implications for group 2 capsule biosynthesis by Meredith, Timothy C, Woodard, Ronald W

“…In Escherichia coli, there are multiple paralogous copies of the enzyme API [A5P (D-arabinose 5-phosphate) isomerase], which catalyses the conversion of the…”
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A metal bridge between two enzyme families. 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus requires a divalent metal for activity by Duewel, H S, Woodard, R W

“…The enzymes 3-deoxy-d-manno-octulosonic acid-8-phosphate synthase (KDO8PS) and 3-deoxy-d-arabino-heptulosonic acid-7-phosphate synthase (DAHPS) catalyze…”
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Structure and Mechanism of 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthase by Radaev, Sergei, Dastidar, Parthasarathi, Patel, Mayur, Woodard, Ronald W., Gatti, Domenico L.

“…3-Deoxy-d-manno-octulosonate 8-phosphate (KDO8P) synthase catalyzes the condensation of phosphoenolpyruvate (PEP) with arabinose 5-phosphate (A5P) to form…”
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Bacillus subtilis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase revisited: resolution of two long-standing enigmas by Wu, Jing, Sheflyan, Galina Ya, Woodard, Ronald W

“…The mono/bifunctional and metallo/non-metallo properties of Bacillus subtilis DAHPS (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) have been…”
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Characterization of N-acetylneuraminic acid synthase isoenzyme 1 from Campylobacter jejuni by Sundaram, Appavu K, Pitts, Lee, Muhammad, Kamilah, Wu, Jing, Betenbaugh, Michael, Woodard, Ronald W, Vann, Willie F

“…Escherichia coli NeuNAc (N-acetylneuraminic acid) synthase catalyses the condensation of PEP (phosphoenolpyruvate) and ManNAc (N-acetylmannosamine) to form…”
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Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase? by Wu, Jing, Howe, David L, Woodard, Ronald W

“…The gene encoding the 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthase from the thermophilic microorganism Thermotoga maritima was cloned, and the…”
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Stereochemical course of the reaction catalyzed by the pyridoxal phosphate-dependent enzyme 1-aminocyclopropane-1-carboxylate synthase by Ramalingam, K, Lee, K.M, Woodard, R.W, Bleecker, A.B, Kende, H

“…(± )-S-adenosyl-DL-(3R*, 4S*)-[3,4-2H2]methionine [a 1:1 mixture of (3R,4S) and (3S,4R)] and (± )-S-adenosyl-DL-(3R*, 4R*)-[3,4-2H2]methionine [a 1:1 mixture…”
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KpsF Is the Arabinose-5-phosphate Isomerase Required for 3-Deoxy-d-manno-octulosonic Acid Biosynthesis and for Both Lipooligosaccharide Assembly and Capsular Polysaccharide Expression in Neisseria meningitidis by Tzeng, Yih-Ling, Datta, Anup, Strole, Christy, Kolli, V. S. Kumar, Birck, Matthew R., Taylor, William P., Carlson, Russell W., Woodard, Ronald W., Stephens, David S.

“…We have identified and defined the function ofkpsF of Neisseria meningitidis and the homologues of kpsF in encapsulated K1 and K5Escherichia coli. KpsF was…”
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Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase by Woodard, R W, Tsai, M D, Floss, H G, Crooks, P A, Coward, J K

“…The steric course of the methyl group transfer catalyzed by catechol O-methyltransferase was studied using S-adenosylmethionine (AdoMet) carrying a methyl…”
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Isolation and Structure Determination of New Macrolide Antibiotics by Hatfield, George M, Woodard, Ronald W, Son, Jong-Keun

“…Three new bafilomycin-like compounds PD 118,576-A1 [1], PD 118,576-A2 [2], and PD 118,576-A3 [3] were isolated from a new soil Streptomyces species (WP 3913)…”
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