Genetic mapping and phenotypic analysis of shotH.3.2 in Drosophila melanogaster
Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in Drosophila melanogaster identified growth control phenotypes in the developing eye. One mutant line from this screen, H.3.2 , was phenotypically characterized using the FLP/FRT system a...
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Published in: | microPublication biology Vol. 2021 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Caltech Library
13-07-2021
|
Subjects: | |
Online Access: | Get full text |
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Summary: | Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in
Drosophila melanogaster
identified growth control phenotypes in the developing eye. One mutant line from this screen,
H.3.2
, was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium.
H.3.2
was found to have a nonsense mutation in
short stop
(
shot
), an
ortholog of the mammalian spectraplakin
dystonin
(
DST
).
shot
and
DST
are involved in cytoskeletal organization and play roles during cell growth and proliferation. |
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review and editing MD: Data curation, Investigation, Formal analysis, Writing - review and editing |
ISSN: | 2578-9430 |
DOI: | 10.17912/micropub.biology.000418 |