Search Results - "Wood, Wg"

Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress by Ip, S-W, Lan, S-H, Lu, H-F, Huang, A-C, Yang, J-S, Lin, J-P, Huang, H-Y, Lien, J-C, Ho, C-C, Chiu, C-F, Wood, Wg, Chung, J-G

“…Capsaicin, a pungent compound found in hot chili peppers, has been reported to have antitumor activities in many human cancer cell lines, but the induction of…”
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Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease by Jeong, Angela, Suazo, Kiall Francis, Wood, W Gibson, Distefano, Mark D, Li, Ling

“…The mevalonate-isoprenoid-cholesterol biosynthesis pathway plays a key role in human health and disease. The importance of this pathway is underscored by the…”
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Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells by Chien, Su-Yu, Wu, Yao-Chung, Chung, Jing-Gung, Yang, Jai-Sing, Lu, Hsu-Feng, Tsou, Mei-Fen, Wood, W G, Kuo, Shou-Jen, Chen, Dar-Ren

“…There has been considerable evidence recently demonstrating the anti-tumour effects of flavonols. Quercetin, an ubiquitous bioactive flavonol, inhibits cells…”
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Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease by Higgs, Douglas R, Tufarelli, Cristina, Stanley, Jackie A Sloane, Garrick, David, Sharpe, Jackie A, Ayyub, Helena, Wood, William G

“…Nearly all human genetic disorders result from a limited repertoire of mutations in an associated gene or its regulatory elements. We recently described an…”
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Advances in the understanding of the congenital dyserythropoietic anaemias by Wickramasinghe, Sunitha N., Wood, William G.

“…Summary The congenital dyserythropoietic anaemias (CDAs) are a heterogeneous group of diseases in which the anaemia is predominantly caused by…”
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Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2 by Anguita, Eduardo, Hughes, Jim, Heyworth, Clare, Blobel, Gerd A, Wood, William G, Higgs, Douglas R

“…How does an emerging transcriptional programme regulate individual genes as stem cells undergo lineage commitment, differentiation and maturation? To answer…”
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Coregulated human globin genes are frequently in spatial proximity when active by Brown, Jill M, Leach, Joanne, Reittie, Joyce E, Atzberger, Ann, Lee-Prudhoe, Jane, Wood, William G, Higgs, Douglas R, Iborra, Francisco J, Buckle, Veronica J

“…The organization of genes within the nucleus may influence transcription. We have analyzed the nuclear positioning of the coordinately regulated [alpha]- and…”
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Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex by Johnson-Anuna, Leslie N, Eckert, Gunter P, Keller, Jan H, Igbavboa, Urule, Franke, Cornelia, Fechner, Thomas, Schubert-Zsilavecz, Manfred, Karas, Michael, Müller, Walter E, Wood, W Gibson

“…Statins have been reported to lower the risk of developing Alzheimer's disease; however, the mechanism of this potentially important neuroprotective action is…”
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Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease by Gibson Wood, W., Eckert, Gunter P., Igbavboa, Urule, Müller, Walter E.

“…Amyloid beta-protein (Aβ) is thought to be one of the primary factors causing neurodegeneration in Alzheimer's disease (AD). This protein is an amphipathic…”
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Brain membrane cholesterol domains, aging and amyloid beta-peptides by Wood, W.Gibson, Schroeder, Friedhelm, Igbavboa, Urule, Avdulov, Nicolai A, Chochina, Svetlana V

“…Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different…”
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Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the α-thalassemia myelodysplasia syndrome (ATMDS) by Higgs, Douglas R, Gibbons, Richard J, Pellagatti, Andrea, Garrick, David, Wood, William G, Malik, Nicola, Ayyub, Helena, Langford, Cordelia, Boultwood, Jacqueline, Wainscoat, James S

“…Inherited mutations of specific genes have elucidated the normal roles of the proteins they encode by relating specific mutations to particular phenotypes. But…”
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Prostaglandin E 2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents by Xu, J, Chalimoniuk, M, Shu, Y, Simonyi, A, Sun, A.Y, Gonzalez, F.A, Weisman, G.A, Wood, W.G, Sun, G.Y

“…Upregulation and activation of phospholipases A 2 (PLA 2) and cyclooxygenases (COX) leading to prostaglandin E 2(PGE 2) production have been implicated in a…”
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In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind β-amyloid by Erickson, Richard R., Dunning, Lisa M., Olson, Douglas A., Cohen, Sheftel J., Davis, Alan T., Wood, W. Gibson, Kratzke, Robert A., Holtzman, Jordan L.

“…The β-amyloids (abetas) are the major components of the plaque observed in the brains of patients with Alzheimer’s disease. The conundrum is that although they…”
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Accelerated Aβ aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain by Yamamoto, Naoki, Igbabvoa, Urule, Shimada, Yukiko, Ohno-Iwashita, Yoshiko, Kobayashi, Mariko, Wood, W.Gibson, Fujita, Shinobu C, Yanagisawa, Katsuhiko

“…Aging and apolipoprotein E4 (apoE4) expression are strong risk factors for the development of Alzheimer's disease (AD); however, their pathological roles…”
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Statins: drugs for Alzheimer's disease? by Eckert, G P, Wood, W G, Müller, W E

“…Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer's disease (AD). This relationship is…”
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Association between alcohol consumption and subclinical carotid atherosclerosis : The study of health in Pomerania by SCHMINKE, Ulf, LUEDEMANN, Jan, BERGER, Klaus, ALTE, Dietrich, MITUSCH, Rolf, WOOD, William G, JASCHINSKI, Anke, BARNOW, Sven, JOHN, Ulrich, KESSLER, Christof

“…Epidemiologic studies have shown a J-shaped association between alcohol consumption and vascular diseases. However, only few studies have reported on the…”
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Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains by Eckert, Gunter P, Igbavboa, Urule, Müller, Walter E, Wood, W.Gibson

“…Lipid rafts have been proposed to be important in a variety of functions including lipid transport, signal transduction and cell growth. There is increasing…”
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A novel molecular basis for β thalassemia intermedia poses new questions about its pathophysiology by Premawardhena, Anuja, Fisher, Christopher A., Olivieri, Nancy F., de Silva, Shanthimala, Sloane-Stanley, Jackie, Wood, William G., Weatherall, David J.

“…During a study of the molecular basis for severe forms of β thalassemia in Sri Lanka, 2 patients were found to be heterozygous for β thalassemia mutations…”
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The Mouse α-Globin Locus Regulatory Element by Gourdon, G., Sharpe, J.A., Higgs, D.R., Wood, W.G.

“…We have identified and cloned the major α globin locus regulatory element in the mouse (maRE). This element shows a high level of sequence homology to its…”
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A novel deletion causing α thalassemia clarifies the importance of the major human alpha globin regulatory element by Viprakasit, Vip, Harteveld, Cornelis L., Ayyub, Helena, Stanley, Jackie S., Giordano, Piero C., Wood, William G., Higgs, Douglas R.

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