Search Results - "Wood, Tammara A"

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin‐Positive Intradermal Progenitors by Marangoni, Roberta Goncalves, Korman, Benjamin D., Wei, Jun, Wood, Tammara A., Graham, Lauren V., Whitfield, Michael L., Scherer, Philipp E., Tourtellotte, Warren G., Varga, John

“…Objective Accumulation of myofibroblasts in fibrotic skin is a hallmark of systemic sclerosis (SSc; scleroderma), but the origins of these cells remain…”
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Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms by Mahoney, J Matthew, Taroni, Jaclyn, Martyanov, Viktor, Wood, Tammara A, Greene, Casey S, Pioli, Patricia A, Hinchcliff, Monique E, Whitfield, Michael L

“…Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and organ fibrosis. The pathogenesis of SSc and its progression are poorly…”
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Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin by Hinchcliff, Monique, Toledo, Diana M., Taroni, Jaclyn N., Wood, Tammara A., Franks, Jennifer M., Ball, Michael S., Hoffmann, Aileen, Amin, Sapna M., Tan, Ainah U., Tom, Kevin, Nesbeth, Yolanda, Lee, Jungwha, Ma, Madeleine, Aren, Kathleen, Carns, Mary A., Pioli, Patricia A., Whitfield, Michael L.

“…Fewer than half of patients with systemic sclerosis demonstrate modified Rodnan skin score improvement during mycophenolate mofetil (MMF) treatment. To…”
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High Rhodotorula Sequences in Skin Transcriptome of Patients with Diffuse Systemic Sclerosis by Arron, Sarah T., Dimon, Michelle T., Li, Zhenghui, Johnson, Michael E., Wood, Tammara A., Feeney, Luzviminda, Angeles, Jorge G., Lafyatis, Robert, Whitfield, Michael L.

“…Previous studies have suggested a role for pathogens as a trigger of systemic sclerosis (SSc), although neither a pathogen nor a mechanism of pathogenesis is…”
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A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis by Taroni, Jaclyn N, Greene, Casey S, Martyanov, Viktor, Wood, Tammara A, Christmann, Romy B, Farber, Harrison W, Lafyatis, Robert A, Denton, Christopher P, Hinchcliff, Monique E, Pioli, Patricia A, Mahoney, J Matthew, Whitfield, Michael L

“…Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibrosis. Internal organ involvement is heterogeneous. It is unknown whether…”
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Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin by Johnson, Michael E, Franks, Jennifer M, Cai, Guoshuai, Mehta, Bhaven K, Wood, Tammara A, Archambault, Kimberly, Pioli, Patricia A, Simms, Robert W, Orzechowski, Nicole, Arron, Sarah, Whitfield, Michael L

“…Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses…”
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Transmission of Pathogenic Bacterial Organisms in the Anesthesia Work Area by LOFTUS, Randy W, KOFF, Matthew D, BURCHMAN, Corey C, SCHWARTZMAN, Joseph D, THORUM, Valerie, READ, Megan E, WOOD, Tammara A, BEACH, Michael L

“…The current prevalence of hospital-acquired infections and evolving amplification of bacterial resistance are major public health concerns. A heightened…”
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Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures by Taroni, Jaclyn N, Martyanov, Viktor, Huang, Chiang-Ching, Mahoney, J Matthew, Hirano, Ikuo, Shetuni, Brandon, Yang, Guang-Yu, Brenner, Darren, Jung, Barbara, Wood, Tammara A, Bhattacharyya, Swati, Almagor, Orit, Lee, Jungwha, Sirajuddin, Arlene, Varga, John, Chang, Rowland W, Whitfield, Michael L, Hinchcliff, Monique

“…Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. There are no…”
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Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature by Derrett-Smith, Emma C, Martyanov, Viktor, Chighizola, Cecilia B, Moinzadeh, Pia, Campochiaro, Corrado, Khan, Korsa, Wood, Tammara A, Meroni, Pier Luigi, Abraham, David J, Ong, Voon H, Lafyatis, Robert, Whitfield, Michael L, Denton, Christopher P

“…Systemic sclerosis (SSc; scleroderma) is an uncommon autoimmune rheumatic disease characterised by autoimmunity, vasculopathy and fibrosis. Gene expression…”
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Regulator combinations identify systemic sclerosis patients with more severe disease by Wang, Yue, Franks, Jennifer M, Yang, Monica, Toledo, Diana M, Wood, Tammara A, Hinchcliff, Monique, Whitfield, Michael L

“…Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder that results in skin fibrosis, autoantibody production, and internal organ dysfunction. We…”
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Bacterial growth kinetics in ACD-A apheresis platelets: comparison of plasma and PAS III storage by Dumont, Larry J., Wood, Tammara A., Housman, Molly, Herschel, Louise, Brantigan, Barbara, Heber, Cheryl, Houghton, Jaime

“…BACKGROUND: Our objective was to determine the growth kinetics of bacteria in leukoreduced apheresis platelets (LR‐AP) in a platelet (PLT) additive solution…”
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A Machine Learning Classifier for Assigning Individual Patients With Systemic Sclerosis to Intrinsic Molecular Subsets by Franks, Jennifer M., Martyanov, Viktor, Cai, Guoshuai, Wang, Yue, Li, Zhenghui, Wood, Tammara A., Whitfield, Michael L.

“…Objective High‐throughput gene expression profiling of tissue samples from patients with systemic sclerosis (SSc) has identified 4 “intrinsic” gene expression…”
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Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial by Gordon, Jessica K, Martyanov, Viktor, Franks, Jennifer M, Bernstein, Elana J, Szymonifka, Jackie, Magro, Cynthia, Wildman, Horatio F, Wood, Tammara A, Whitfield, Michael L, Spiera, Robert F

“…To assess the safety and efficacy of treatment with belimumab in patients with early diffuse cutaneous systemic sclerosis (dcSSc) treated with background…”
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Identification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors by Grant, Gavin D, Brooks, 3rd, Lionel, Zhang, Xiaoyang, Mahoney, J Matthew, Martyanov, Viktor, Wood, Tammara A, Sherlock, Gavin, Cheng, Chao, Whitfield, Michael L

“…We identify the cell cycle-regulated mRNA transcripts genome-wide in the osteosarcoma-derived U2OS cell line. This results in 2140 transcripts mapping to 1871…”
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Machine learning predicts stem cell transplant response in severe scleroderma by Franks, Jennifer M, Martyanov, Viktor, Wang, Yue, Wood, Tammara A, Pinckney, Ashley, Crofford, Leslie J, Keyes-Elstein, Lynette, Furst, Daniel E, Goldmuntz, Ellen, Mayes, Maureen D, McSweeney, Peter, Nash, Richard A, Sullivan, Keith M, Whitfield, Michael L

“…The Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial demonstrated clinical benefit of haematopoietic stem cell transplant (HSCT) compared with…”
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Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis by Hinchcliff, Monique, Huang, Chiang-Ching, Wood, Tammara A., Matthew Mahoney, J., Martyanov, Viktor, Bhattacharyya, Swati, Tamaki, Zenshiro, Lee, Jungwha, Carns, Mary, Podlusky, Sofia, Sirajuddin, Arlene, Shah, Sanjiv J., Chang, Rowland W., Lafyatis, Robert, Varga, John, Whitfield, Michael L.

“…Heterogeneity in systemic sclerosis (SSc) confounds clinical trials. We previously identified “intrinsic” gene expression subsets by analysis of SSc skin. Here…”
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Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis by Chakravarty, Eliza F, Martyanov, Viktor, Fiorentino, David, Wood, Tammara A, Haddon, David James, Jarrell, Justin Ansel, Utz, Paul J, Genovese, Mark C, Whitfield, Michael L, Chung, Lorinda

“…Systemic sclerosis is an autoimmune disease characterized by inflammation and fibrosis of the skin and internal organs. We sought to assess the clinical and…”
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Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement by Showalter, Kimberly, Spiera, Robert, Magro, Cynthia, Agius, Phaedra, Martyanov, Viktor, Franks, Jennifer M, Sharma, Roshan, Geiger, Heather, Wood, Tammara A, Zhang, Yaxia, Hale, Caryn R, Finik, Jackie, Whitfield, Michael L, Orange, Dana E, Gordon, Jessica K

“…We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma)…”
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A genomic meta-analysis of clinical variables and their association with intrinsic molecular subsets in systemic sclerosis by Franks, Jennifer M, Toledo, Diana M, Martyanov, Viktor, Wang, Yue, Huang, Suiyuan, Wood, Tammara A, Spino, Cathie, Chung, Lorinda, Denton, Christopher P, Derrett-Smith, Emma, Gordon, Jessica K, Spiera, Robert, Domsic, Robyn, Hinchcliff, Monique, Khanna, Dinesh, Whitfield, Michael L

“…Four intrinsic molecular subsets (inflammatory, fibroproliferative, limited, normal-like) have previously been identified in SSc and are characterized by…”
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Nilotinib (Tasigna™) in the treatment of early diffuse systemic sclerosis: an open-label, pilot clinical trial by Gordon, Jessica K, Martyanov, Viktor, Magro, Cynthia, Wildman, Horatio F, Wood, Tammara A, Huang, Wei-Ti, Crow, Mary K, Whitfield, Michael L, Spiera, Robert F

“…Tyrosine kinase inhibitors (TKI) are medications of interest in the treatment of Systemic Sclerosis (SSc) because of their ability to inhibit pathways involved…”
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