Search Results - "Wood, Matthew J."

Advances in oligonucleotide drug delivery by Roberts, Thomas C., Langer, Robert, Wood, Matthew J. A.

“…Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing…”
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DNA Cage Delivery to Mammalian Cells by Walsh, Anthony S, Yin, HaiFang, Erben, Christoph M, Wood, Matthew J. A, Turberfield, Andrew J

“…DNA cages are nanometer-scale polyhedral structures formed by self-assembly from synthetic DNA oligonucleotides. Potential applications include in vivo imaging…”
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes by Wood, Matthew J A, Alvarez-Erviti, Lydia, Seow, Yiqi, Yin, HaiFang, Betts, Corinne, Lakhal, Samira

“…To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that…”
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An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies by McClorey, Graham, Wood, Matthew J

“…Highlights • Recent human clinical trial data on RNAi approaches to gene down-regulation for genetic diseases. • Overview of current anti-microRNA drugs with…”
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Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking by Murphy, Daniel E., de Jong, Olivier G., Brouwer, Maarten, Wood, Matthew J., Lavieu, Grégory, Schiffelers, Raymond M., Vader, Pieter

“…Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular signaling via the delivery of effector molecules. Interestingly,…”
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Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods by Baranyai, Tamás, Herczeg, Kata, Onódi, Zsófia, Voszka, István, Módos, Károly, Marton, Nikolett, Nagy, György, Mäger, Imre, Wood, Matthew J, El Andaloussi, Samir, Pálinkás, Zoltán, Kumar, Vikas, Nagy, Péter, Kittel, Ágnes, Buzás, Edit Irén, Ferdinandy, Péter, Giricz, Zoltán

“…Exosomes are emerging targets for biomedical research. However, suitable methods for the isolation of blood plasma-derived exosomes without impurities have not…”
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Therapeutic approaches for Duchenne muscular dystrophy by Roberts, Thomas C., Wood, Matthew J. A., Davies, Kay E.

“…Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a priority candidate for molecular and cellular therapeutics. Although rare, it is…”
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The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease by Roberts, Thomas C., Morris, Kevin V., Wood, Matthew J. A.

“…Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell…”
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Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study by Cirak, Sebahattin, MD, Arechavala-Gomeza, Virginia, PhD, Guglieri, Michela, MD, Feng, Lucy, PhD, Torelli, Silvia, PhD, Anthony, Karen, PhD, Abbs, Stephen, PhD, Garralda, Maria Elena, Prof, Bourke, John, MD, Wells, Dominic J, Prof, Dickson, George, Prof, Wood, Matthew JA, MD PhD, Wilton, Steve D, Prof, Straub, Volker, Prof, Kole, Ryszard, Prof, Shrewsbury, Stephen B, MD, Sewry, Caroline, Prof, Morgan, Jennifer E, PhD, Bushby, Kate, Prof, Muntoni, Francesco, Prof

“…Summary Background We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658 phosphorodiamidate…”
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The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain by Wood, Matthew J., Miller, Rachel E., Malfait, Anne-Marie

“…Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is one of the leading causes of chronic pain and is increasing in…”
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Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression by Willms, Eduard, Cabañas, Carlos, Mäger, Imre, Wood, Matthew J A, Vader, Pieter

“…Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs) that function as mediators of intercellular communication by…”
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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting by Wiklander, Oscar P. B., Nordin, Joel Z., O'Loughlin, Aisling, Gustafsson, Ylva, Corso, Giulia, Mäger, Imre, Vader, Pieter, Lee, Yi, Sork, Helena, Seow, Yiqi, Heldring, Nina, Alvarez-Erviti, Lydia, Smith, CI Edvard, Le Blanc, Katarina, Macchiarini, Paolo, Jungebluth, Philipp, Wood, Matthew J. A., Andaloussi, Samir EL

“…Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in a diverse range of biological processes. For future…”
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Targeting RNA to treat neuromuscular disease by Muntoni, Francesco, Wood, Matthew J. A

“…Key Points Neuromuscular disorders comprise a heterogeneous group of clinical conditions that primarily affect one or more components of the neuromuscular unit…”
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Antisense oligonucleotides: the next frontier for treatment of neurological disorders by Rinaldi, Carlo, Wood, Matthew J. A.

“…Key Points Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify…”
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A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA by de Jong, Olivier G., Murphy, Daniel E., Mäger, Imre, Willms, Eduard, Garcia-Guerra, Antonio, Gitz-Francois, Jerney J., Lefferts, Juliet, Gupta, Dhanu, Steenbeek, Sander C., van Rheenen, Jacco, El Andaloussi, Samir, Schiffelers, Raymond M., Wood, Matthew J. A., Vader, Pieter

“…Extracellular vesicles (EVs) form an endogenous transport system for intercellular transfer of biological cargo, including RNA, that plays a pivotal role in…”
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Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER by Heusermann, Wolf, Hean, Justin, Trojer, Dominic, Steib, Emmanuelle, von Bueren, Stefan, Graff-Meyer, Alexandra, Genoud, Christel, Martin, Katrin, Pizzato, Nicolas, Voshol, Johannes, Morrissey, David V, Andaloussi, Samir E L, Wood, Matthew J, Meisner-Kober, Nicole C

“…Exosomes are nanovesicles released by virtually all cells, which act as intercellular messengers by transfer of protein, lipid, and RNA cargo. Their…”
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Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons by Heman-Ackah, Sabrina M, Manzano, Raquel, Hoozemans, Jeroen J M, Scheper, Wiep, Flynn, Rowan, Haerty, Wilfried, Cowley, Sally A, Bassett, Andrew R, Wood, Matthew J A

“…The recent generation of induced pluripotent stem cells (iPSCs) from a patient with Parkinson's disease (PD) resulting from triplication of the α-synuclein…”
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Assessment of RT-qPCR normalization strategies for accurate quantification of extracellular microRNAs in murine serum by Roberts, Thomas C, Coenen-Stass, Anna M L, Wood, Matthew J A

“…Extracellular microRNAs (miRNAs) are under investigation as minimally-invasive biomarkers for a wide range of disease conditions. We have recently shown in a…”
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The viral protein corona directs viral pathogenesis and amyloid aggregation by Ezzat, Kariem, Pernemalm, Maria, Pålsson, Sandra, Roberts, Thomas C., Järver, Peter, Dondalska, Aleksandra, Bestas, Burcu, Sobkowiak, Michal J., Levänen, Bettina, Sköld, Magnus, Thompson, Elizabeth A., Saher, Osama, Kari, Otto K., Lajunen, Tatu, Sverremark Ekström, Eva, Nilsson, Caroline, Ishchenko, Yevheniia, Malm, Tarja, Wood, Matthew J. A., Power, Ultan F., Masich, Sergej, Lindén, Anders, Sandberg, Johan K., Lehtiö, Janne, Spetz, Anna-Lena, EL Andaloussi, Samir

“…Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate…”
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Genetic therapies for RNA mis-splicing diseases by Hammond, Suzan M, Wood, Matthew J.A

“…RNA mis-splicing diseases account for up to 15% of all inherited diseases, ranging from neurological to myogenic and metabolic disorders. With greatly…”
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