Search Results - "Wood, Jason G."

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan by Jones, Brian C., Wood, Jason G., Chang, Chengyi, Tam, Austin D., Franklin, Michael J., Siegel, Emily R., Helfand, Stephen L.

“…In gonadal tissues, the Piwi-interacting (piRNA) pathway preserves genomic integrity by employing 23–29 nucleotide (nt) small RNAs complexed with argonaute…”
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Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span by Pu, Mintie, Ni, Zhuoyu, Wang, Minghui, Wang, Xiujuan, Wood, Jason G, Helfand, Stephen L, Yu, Haiyuan, Lee, Siu Sylvia

“…Functional data indicate that specific histone modification enzymes can be key to longevity in Caenorhabditis elegans, but the molecular basis of how chromatin…”
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Chromatin structure and transposable elements in organismal aging by Wood, Jason G, Helfand, Stephen L

“…Epigenetic regulatory mechanisms are increasingly appreciated as central to a diverse array of biological processes, including aging. An association between…”
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Chromatin remodeling in the aging genome of Drosophila by Wood, Jason G., Hillenmeyer, Sara, Lawrence, Charles, Chang, Chengyi, Hosier, Suzanne, Lightfoot, Will, Mukherjee, Eric, Jiang, Nan, Schorl, Christoph, Brodsky, Alexander S., Neretti, Nicola, Helfand, Stephen L.

“…Summary Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during…”
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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan by Sinclair, David A, Howitz, Konrad T, Bitterman, Kevin J, Cohen, Haim Y, Lamming, Dudley W, Lavu, Siva, Wood, Jason G, Zipkin, Robert E, Chung, Phuong, Kisielewski, Anne, Zhang, Li-Li, Scherer, Brandy

“…In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie…”
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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae by Sinclair, David A, Anderson, Rozalyn M, Bitterman, Kevin J, Wood, Jason G, Medvedik, Oliver

“…Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon,…”
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Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging by Jiang, Nan, Du, Guyu, Tobias, Ethan, Wood, Jason G, Whitaker, Rachel, Neretti, Nicola, Helfand, Stephen L

“…During aging, changes in chromatin state that alter gene transcription have been postulated to result in expression of genes that are normally silenced,…”
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Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels by Anderson, Rozalyn M., Bitterman, Kevin J., Wood, Jason G., Medvedik, Oliver, Cohen, Haim, Lin, Stephen S., Manchester, Jill K., Gordon, Jeffrey I., Sinclair, David A.

“…Yeast deprived of nutrients exhibit a marked life span extension that requires the activity of the NAD+-dependent histone deacetylase, Sir2p. Here we show that…”
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Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila by Wood, Jason G., Jones, Brian C., Jiang, Nan, Chang, Chengyi, Hosier, Suzanne, Wickremesinghe, Priyan, Garcia, Meyrolin, Hartnett, Davis A., Burhenn, Lucas, Neretti, Nicola, Helfand, Stephen L.

“…Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, that constitute a large percentage of the DNA content of…”
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Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster by Wood, Jason G., Schwer, Bjoern, Wickremesinghe, Priyan C., Hartnett, Davis A., Burhenn, Lucas, Garcia, Meyrolin, Li, Michael, Verdin, Eric, Helfand, Stephen L.

“…Sirtuins are an evolutionarily conserved family of NAD⁺-dependent deacylases that control metabolism, stress response, genomic stability, and longevity. Here,…”
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Sirt6 regulates lifespan in Drosophila melanogaster by Taylor, Jackson R, Wood, Jason G, Mizerak, Evan, Hinthorn, Samuel, Liu, Julianna, Finn, Matthew, Gordon, Sarah, Zingas, Louis, Chang, Chengyi, Klein, Mark A, Denu, John M, Gorbunova, Vera, Seluanov, Andrei, Boeke, Jef D, Sedivy, John M, Helfand, Stephen L

“…Sirt6 is a multifunctional enzyme that regulates diverse cellular processes such as metabolism, DNA repair, and aging. Overexpressing Sirt6 extends lifespan in…”
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Unusual Proliferation Arrest and Transcriptional Control Properties of a Newly Discovered E2F Family Member, E2F-6 by Gaubatz, Stefan, Wood, Jason G., Livingston, David M.

“…E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional…”
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans by Wood, J.G, Rogina, B, Lavu, S, Howitz, K, Helfand, S.L, Tatar, M, Sinclair, D

“…Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the…”
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Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner by Whitaker, Rachel, Faulkner, Shakeela, Miyokawa, Reika, Burhenn, Lucas, Henriksen, Mark, Wood, Jason G, Helfand, Stephen L

“…Sir2, a member of the sirtuin family of protein acylases, deacetylates lysine residues within many proteins and is associated with lifespan extension in a…”
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Small molecules that regulate lifespan: evidence for xenohormesis by LAMMING, Dudley W, WOOD, Jason G, SINCLAIR, David A

“…Barring genetic manipulation, the diet known as calorie restriction (CR) is currently the only way to slow down ageing in mammals. The fact that CR works on…”
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dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster by Bauer, Johannes H, Morris, Siti Nur Sarah, Chang, Chengyi, Flatt, Thomas, Wood, Jason G, Helfand, Stephen L

“…Calorie Restriction (CR) is a well established method of extending life span in a variety of organisms. In the fruit fly D. melanogaster, CR is mediated at…”
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Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner by Whitaker, Rachel, Faulkner, Shakeela, Miyokawa, Reika, Burhenn, Lucas, Henriksen, Mark, Wood, Jason G., Helfand, Stephen L.

“…Sir2, a member of the sirtuin family of protein acylases, deacetylates lysine residues within many proteins and is associated with lifespan extension in a…”
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TPE or not TPE? It's no longer a question by Wood, Jason G, Sinclair, David A

“…Telomere shortening limits cancer progression and might contribute to aging in humans. In yeast, genes placed near telomeres are silenced, a phenomenon known…”
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Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster by Wood, Jason G, Whitaker, Rachel, Helfand, Stephen L

“…Drosophila melanogaster is one of the most widely used genetic model systems in biology. The ease of working in an invertebrate model system allows the design…”
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Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels by Anderson, Rozalyn M., Bitterman, Kevin J., Wood, Jason G., Medvedik, Oliver, Cohen, Haim, Lin, Stephen S., Manchester, Jill K., Gordon, Jeffrey I., Sinclair, David A.

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